I-6-Amino-5-Bromoquinoxaline CAS 50358-63-9 Purity >99.0% (HPLC) Brimonidine Tartrate Intermediate
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Igama Lekhemikhali | 6-Amino-5-Bromoquinoxaline |
Omqondofana | I-5-Bromoquinoxalin-6-Amine;I-5-Bromo-6-Quinoxalinamine;5-Bromo-6-Aminoquinoxaline |
Ukungcola | I-Brimonidine EP Ukungcola B |
Inombolo ye-CAS | 50358-63-9 |
Inombolo yeCAT | I-RF2515 |
Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani angama-35 ngenyanga |
I-Molecular Formula | I-C8H6BrN3 |
Isisindo samangqamuzana | 224.06 |
I-Melting Point | 153.0 ukuze 157.0 ℃ |
Ukuminyana | 1.744±0.06 g/cm3 |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Ensundu ukuya Ephuzi |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) |
I-Melting Point | 153.0 ~ 157.0℃ |
Ukulahlekelwa Ekumisweni | <1.00% |
Ubukhulu.Ukungcola Ngamunye | <0.50% |
Ukungcola Okuphelele | <1.00% |
I-Infrared Spectrum | Ivumelana Nesakhiwo |
I-Proton NMR Spectrum | Ivumelana Nesakhiwo |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Intermediate ye-Brimonidine Tartrate (CAS: 70359-46-5) |
I-Melting Point
Sebenzisa indlela yokuhlola evamile futhi ukhuphule izinga lokushisa elingu-1.5℃/ngomzuzu.Kufanele incibilike phakathi kuka-153.0 ~ 157.0℃
Ukulahlekelwa Ekumisweni
Hhayi ngaphezulu kuka-1.0% Kunqunywa ku-1.0g ngokomisa kuhhavini ongu-105 ℃ kuze kufike esisindweni esingaguquki.
Izinhlanganisela ezihlobene (HPLC)
Isistimu yeChromatographic:
Ikholomu: ODS, C18,
Umtshina wavelengh: 264nm
Izinga lokugeleza: 1.0 ml ngomzuzu
Isigaba seselula:
Lungiselela ingxube ehlungiwe kanye ne-degassed ye-buffer ( chaza i-2.6g ye-Sodium 1-heptanesulfonate ku-690ml yamanzi) -methanol-glacial acetic acid-triethylamine (690: 310: 7.5: 2.5) .
Ukulungiswa kwesixazululo sesampula:
Chaza isampula enesisindo esinembile esingu-25.0mg esigabeni samaselula esingu-25ml.
Inqubo:
Jova umthamo we-10 l wesixazululo sesampula bese urekhoda ama-chromatogram izikhathi ezi-4 zesikhathi sokugcina sesiqongo esikhulu.Bala iziqongo zokungcola nciphisa isiqongo esingenalutho.Isamba
ukungcola okungadluli ku-1.00%, noma yikuphi ukungcola komuntu ngamunye kungabi ngaphezu kuka-0.50%.
Umzila Wokuhlanganisa we-6-Amino-5-Bromoquinoxaline (CAS: 50358-63-9)
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
Indlela Yokuthenga?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eRussia, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi enhle kakhulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-6-Amino-5-Bromoquinoxaline (i-CAS: 50358-63-9) iyingxenye ebalulekile ye-quinoxaline derivatives.I-6-Amino-5-Bromoquinoxaline isetshenziswa njenge-intermediate yemithi, i-intermediate ye-Brimonidine Tartrate (CAS: 70359-46-5).I-Brimonidine iyisivimbeli se-α2-receptor esikhetha kakhulu, esakhiwe ngempumelelo yi-US Company Allergan, okuwumuthi wamehlo.Inganciphisa umfutho we-intraocular (IOP).I-Brimonidine Tartrate ophthalmic solution ethengiswayo emakethe ifomu le-brimonidine tartrate, okuwumuthi omuhle owehlisa i-IOP we-glaucoma evulekile engelaphekiyo kanye nokwelashwa komfutho wegazi ophakeme we-ocular weziguli, kodwa futhi namazinga e-argon laser IOP.Isixazululo se-Brimonidine Tartrate ophthalmic sinezindlela ezimbili zokusebenza ngokunciphisa ukukhiqizwa kwamahlaya ane-aqueous kanye nokwandisa ungqimba lwe-pigment lwezinjongo zokwelapha zokuphuma kwe-liquid scleral.Ngemuva kokuwela esweni, umphumela uyashesha, futhi ungafinyelela phezulu uma usebenzisa kufika ku-2h, futhi isikhathi esisebenzayo singagcina i-12h.Igazi lingathola iminonjana yezidakamizwa kuphela.Lo mkhiqizo une-metabolism ye-first pass metabolism esibindini, futhi ama-metabolites akhishwa umchamo yizinso.Ukumuncwa okuhlelekile nokusabalalisa akuthinteki, futhi abantu abadala abadingi ukulungiswa komthamo.Isixazululo se-Brimonidine Tartrate ophthalmic uma siqhathaniswa namanye ama-α-blockers, i-fat-soluble incane, kuyilapho akulula ukudlula umgoqo wegazi-ubuchopho futhi ayikhiqizi i-sedation, i-hypotension kanye nokunye okufanayo okungahambisani ne-clonidine central.