7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3 Tolvaptan Intermediate
Ukunikezwa Komkhiqizi, Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo
I-Tolvaptan kanye Nezixhumanisi Ezihlobene:
I-Tolvaptan CAS 150683-30-0
7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one CAS 160129-45-3
o-Toluoyl Chloride CAS 933-88-0
I-4-Amino-2-Methylbenzoic Acid CAS 2486-75-1
I-2-Methyl-4-Nitrobenzoic Acid CAS 1975-51-5
Igama Lekhemikhali | 7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one |
Omqondofana | 7-Chloro-1,2,3,4-tetrahydro-5H-1-benzazepin-5-one;7-Chloro-3,4-dihydro-1H-benzo[b]azepin-5(2H)-one |
Inombolo ye-CAS | 160129-45-3 |
Inombolo yeCAT | I-RF-PI395 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C10H10ClNO |
Isisindo samangqamuzana | 195.65 |
I-Melting Point | 103.0 ukuze 107.0 ℃ |
Ukuncibilika | I-Soluble ku-Methanol |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Okuluhlaza Okukhanyayo kuya Kumpushana Ophuzi Okhanyayo |
Izindlela Zokuhlonza | I-NMR, HPLC |
Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.0% (HPLC) |
Ukulahlekelwa Ekumisweni | ≤1.0% |
Izinsalela ekushiseni | ≤0.50% |
Noma Ikuphi Ukungcola Okukodwa | ≤0.50% |
Ukungcola Okuphelele | ≤1.0% |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Intermediate of Tolvaptan (CAS 150683-30-0), ukwelashwa kwe-Hyponatremia |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.
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I-7-Chloro-1,2,3,4-tetrahydrobenzo[b]azepin-5-one (CAS 160129-45-3) iphakathi ekuhlanganiseni kwe-Tolvaptan (CAS 150683-30-0).I-Tolvaptan iyisithathisi esikhethiwe, esiqhudelanayo ngomlomo esingasebenzi i-arginine vasopressin V2 receptor antagonist ene-IC50 ye-1.28µM yokuvimbela ukuhlangana kweplatelet eyenziwe yi-AVP.I-Tolvaptan isetshenziselwa ukwelapha i-hyponatremia ehambisana nokuhluleka kwenhliziyo, i-cirrhosis, kanye ne-syndrome ye-antidiuretic hormone engafaneleki.U-Tolvaptan usezivivinyweni zomtholampilo ezisheshayo zesifo sezinso se-polycystic.Ukwelashwa nge-Tolvaptan kubangela ukuncipha kwesisindo somzimba ngokushesha nangokuqhubekayo okuhambisana nokwanda kokuphuma komchamo, kuthuthukisa kanye/noma kwenza kujwayelekile i-serum sodium ezigulini ezine-hyponatremic, kunciphisa izimpawu nezimpawu zokuminyana futhi kwandise ukoma.