I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2 Ukuhlanzeka >99.0% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Incazelo emfushane:

Igama: 7-Chloro-6-Nitro-4-Hydroxyquinazoline

I-CAS: 53449-14-2

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Impushana Ephuzi Okukhanyayo ukuya Kunsundu Okhanyayo

I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	I-7-Chloro-6-Nitro-4-Hydroxyquinazoline
Omqondofana	I-7-Chloro-4-Hydroxy-6-Nitroquinazoline;7-Chloro-6-Nitro-4-Quinazolinol;7-Chloro-6-Nitro-4-Quinazolinone;7-Chloro-6-Nitro-4(3H)-Quinazolinone;7-Chloro-6-Nitro-3,4-Dihydroquinazolin-4-one;7-Chloro-6-Nitroquinazolin-4(3H)-enye
Inombolo ye-CAS	53449-14-2
Inombolo yeCAT	I-RF-PI2030
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C8H4ClN3O3
Isisindo samangqamuzana	225.59
Ukuzwela	Ukushisa Kuyazwela
Ukuncibilika	Incibilika Kancane ku-Dimethylformamide
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Ephuzi Ngokukhanyayo kuya Kuphuphu Olunsundu Okhanyayo
I-Identification (HPLC)	Isikhathi Sokugcinwa Kwesampula Kufanele Sifane Nezinga
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
I-Melting Point	300.0~303.0℃
Okuqukethwe kwamanzi (KF)	<0.50%
Izinsalela ekushiseni	<0.30%
Ukungcola 1	<0.50% (7-Chloro-4-Hydroxyquinazoline CAS: 31374-18-2)
Ukungcola 2	<0.50% (5,7-Dichloro-4[1H]quinazolinone)
Ukungcola 3	<1.00% (7-Chloro-8-Nitro-4[1H]quinazolinone)
Okunye Ukungcola Okukodwa	<0.20%
Ukungcola Okuphelele	<1.00%
Izinsimbi Ezisindayo (njenge-Pb)	<20ppm
I-Infrared Spectrum	Ivumelana Nesakhiwo
I-Proton NMR Spectrum	I-Proton NMR Spectrum
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate ye-Afatinib, i-Afatinib Dimaleate

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-7-Chloro-6-Nitro-4-Hydroxyquinazoline (i-CAS: 53449-14-2) iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib iwumndeni we-ErbB ongahlehliseki wama-blocker acindezela ukudluliswa kolwazi futhi avimbe izindlela ezinkulu ezibandakanyeka ekukhuleni kweseli lomdlavuza nokuhlukana.Ngenxa yokuthi indlela yokudlulisa ulwazi lomndeni we-ErbB ingaqalwa ama-homodimer amaningi nama-heterodimers, ukuvinjelwa ngasikhathi sinye kwamalungu amaningi omndeni we-ErbB (afana ne-EGFR, HER2, ErbB3 kanye ne-ErbB4) kungaphazamisa ngempumelelo ukudluliswa kolwazi oluya phansi.I-Afatinib isetshenziselwa ukwelapha uhlobo oluthile lomdlavuza wamaphaphu (umdlavuza wamaphaphu ongewona omncane) osusabalele kwezinye izingxenye zomzimba.Kungokwesigaba sezidakamizwa ezaziwa ngokuthi ama-kinase inhibitors.Isebenza ngokunciphisa noma ukumisa ukukhula kwamangqamuzana omdlavuza.Ibophezela kuphrotheni ethile (epidermal receptor-EGFR) kwezinye izimila.