I-7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3 Ubumsulwa >99.0% (HPLC) I-Afatinib Dimaleate Intermediate Factory

Incazelo emfushane:

Igama Lekhemikhali: 7-Fluoro-6-Nitroquinazolin-4(1H)-one

I-CAS: 162012-69-3

Ubumsulwa: >99.0% (HPLC)

Ikristalu Ephuzi Ephuzi kuya Kubomvu noma Impushana

I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	7-Fluoro-6-Nitroquinazolin-4(1H)-enye
Omqondofana	I-7-Fluoro-6-Nitroquinazolin-4 (3H) -enye;I-7-Fluoro-4-Hydroxy-6-Nitroquinazoline;I-7-Fluoro-6-Nitroquinazolin-4-ol;I-7-Fluoro-6-Nitro-4-Hydroxyquinazoline;7-Fluoro-6-Nitro-1H-Quinazolin-4-one
Inombolo ye-CAS	162012-69-3
Inombolo yeCAT	I-RF-PI2025
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C8H4FN3O3
Isisindo samangqamuzana	209.13
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Ikristalu Ephuzi Ephuzi kuya Kubomvu noma Impushana
1 H NMR Spectrum	Ihambisana Nesakhiwo
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
Ukulahlekelwa Ekumisweni	<0.50%
Ukungcola Okuphelele	<1.00%
I-Proton NMR Spectrum	Ivumelana Nesakhiwo
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-7-Fluoro-6-Nitroquinazolin-4 (1H)-one (CAS: 162012-69-3) iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib iwumndeni we-ErbB ongahlehliseki wama-blocker acindezela ukudluliswa kolwazi futhi avimbe izindlela ezinkulu ezibandakanyeka ekukhuleni kweseli lomdlavuza nokuhlukana.Ngenxa yokuthi indlela yokudlulisa ulwazi lomndeni we-ErbB ingaqalwa ama-homodimer amaningi nama-heterodimers, ukuvinjelwa ngasikhathi sinye kwamalungu amaningi omndeni we-ErbB (afana ne-EGFR, HER2, ErbB3 kanye ne-ErbB4) kungaphazamisa ngempumelelo ukudluliswa kolwazi oluya phansi.I-Afatinib isidakamizwa esigunyazwe ukwelashwa kwe-non-small cell lung carcinoma(NSCLC), esakhiwe ngu-Boehringer Ingelheim.Isebenza njenge-angiokinase inhibitor.Njenge-lapatinib ne-neratinib, i-afatinib iyi-tyrosine kinase inhibitor (TKI) ephinde ivimbele ngokungenakulungiseka i-epidermal growth factor receptor 2 (Her2) kanye ne-epidermal growth factor receptor (EGFR) kinases.I-Afatinib ayisebenzi kuphela ngokumelene nokuguqulwa kwe-EGFR okuqondiswe isizukulwane sokuqala se-TKIs likeerlotinib noma i-gefitinib, kodwa futhi ngokumelene nalezo ezingazweli kulezi zindlela zokwelapha ezijwayelekile.Ngenxa yomsebenzi wayo owengeziwe ngokumelene ne-Her2, kuphenywa umdlavuza webele kanye neminye imidlavuza eqhutshwa yi-EGFR kanye ne-Her2.