I-S-Adenosyl-L-Methionine (Ademetionine; SAMe) CAS 29908-03-0
I-Ruifu Chemical ingumkhiqizi ohamba phambili we-S-Adenosyl-L-Methionine (Ademetionine; SAMe) (CAS: 29908-03-0) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-S-Adenosyl-L-Methionine,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-S-Adenosyl-L-Methionine |
| Omqondofana | I-Ademetionine;S-Adenosylmethionine;SAMe;SAM;I-AdoMet |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 29908-03-0 |
| I-Molecular Formula | I-C15H22N6O5S |
| Isisindo samangqamuzana | 398.44 g/mol |
| I-Melting Point | 267.0~269.0℃ |
| Kuyazwela | I-Hygroscopic kakhulu |
| Ukuncibilika kwamanzi | Incibilika Emanzini |
| Iphunga & Ukunambitha | Izici |
| I-COA ne-MSDS | Iyatholakala |
| Isampula | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Cishe Impushana Enhle Emhlophe (Very Hygroscopic) | Kuqinisekisiwe |
| Ukuncibilika | Incibilika Emanzini | |
| Ukuhlonza | 1. Ukusabela kwamakhemikhali | Ukusabela okuhle |
| 2. I-IR: Ihambisana ne-spectrum etholwe nge-RS | Kuqinisekisiwe | |
| 3. Isikhathi sokugcina senani eliphakeme kakhulu sihlangabezana nezicelo | Kuqinisekisiwe | |
| I-Acid Value | 1.5~2.5 | 1.9 |
| Ukucaca kanye Nombala Wesixazululo | Ayinambala Kakhulu Kune-RS Y1 | Kuqinisekisiwe |
| Amanzi nguKarl Fischer | ≤3.00% | 2.2% |
| Izinsalela ekushiseni | ≤0.30% | 0.14% |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
| I-Endotoxin | ≤0.3EU/mg | Kuqinisekisiwe |
| I-Microbiological | Kufanele Uhlangabezane Nemfuneko | |
| Inani Lepuleti Eliphelele | ≤1000cfu/g | 55cfu/g |
| Imvubelo & Isikhunta | ≤100cfu/g | 12cfu/g |
| E. Coli | Akukho/10g | Iyahambisana |
| S. Aureus | Akukho/10g | Iyahambisana |
| I-Salmonella | Akukho/10g | Iyahambisana |
| I-S-Adenosyl-L-Homocysteine | ≤0.50% | 0.10% |
| I-Methioadenosine | ≤1.00% | 0.24% |
| I-Adenine | ≤0.50% | 0.09% |
| Izinto Ezihlobene | ||
| Okunye Ukungcola Okukhulu Kakhulu | ≤0.20% | 0.01% |
| Okunye Ukungcola Okuphelele | ≤0.50% | 0.006% |
| (S,S) Isomer | >62.0% | 79.4% |
| I-Butanedisulfonate | 46.0~49.0% (Kusekelwe Komisiwe) | 47.5% |
| I-Ademetionine | 50.0~53.0% (Kusekelwe Komisiwe) | 52.1% |
| Ingqikithi Yokuqukethwe | >97.5% (Okusekelwe Komisiwe) | 99.6% |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
| I-Shelf Life | Iminyaka engu-2 Lapho Igcinwe Ngokufanele | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
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Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
Amakhodi Engozi R49 - Angabangela umdlavuza ngokuhogela
R23 - Ubuthi ngokuhogela
R34 - Ibangela ukusha
Incazelo Yezokuphepha S53 - Gwema ukuchayeka - thola imiyalelo ekhethekile ngaphambi kokusetshenziswa.
S23 - Ungawuphefumuli umhwamuko.
I-S36/37/39 - Gqoka izingubo zokuzivikela ezifanele, amagilavu nokuvikela iso/ubuso.
S45 - Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
I-HS Code 2934999099
I-S-Adenosyl-L-Methionine (i-Ademetionine; i-SAMe) (i-CAS: i-29908-03-0) i-cosubstrate evamile ehilelekile ekudlulisweni kweqembu le-methyl.I-SAMe yatholwa okokuqala e-Italy ngu-GL Cantoni ngo-1952, i-SAMe iyi-molecule ekhiqizwa njalo yiwo wonke amangqamuzana aphilayo, ingavimbela umdlavuza wesibindi, ikhuthaze ukwakheka kwezicubu ze-cartilaginous kanye ne-concrescence, ingasiza ukulwa nokucindezeleka, isifo se-alzheimer, isifo sesibindi, nobuhlungu i-osteoarthritis, i-SAMe manje seyaziwa emhlabeni wonke njengekhambi elibalulekile lokwelapha izifo zesibindi.Namuhla i-SAMe ivame ukusetshenziswa kwezokwelapha, embonini yokudla yokunakekelwa kwezempilo kokubili ezimakethe zasekhaya nezamazwe ngamazwe.I-SAMe idayiswa e-United States njengesengezo sokudla.
1. I-S-Adenosyl-L-Methionine iyisakhi esihle sesibindi, esingavimbela utshwala, izidakamizwa kanye nokulimala kwamangqamuzana esibindi;
2. I-S-Adenosyl-L-Methionine inomphumela obalulekile wokuvimbela ku-hepatitis engapheli esebenzayo nezinye izici ezibangela ukulimala kwesibindi, isifo senhliziyo, umdlavuza nokunye.
3. I-S-Adenosyl-L-Methionine itholakale iphumelela njengemithi yokwelapha isifo samathambo nokucindezeleka okukhulu.
4. E-United States, i-SAM ithengiswa njengesengezo sokudla okunempilo ngaphansi kwegama lokumaketha elithi SAM-e (liphinde lipelwe ngokuthi SAME noma SAMe).Ezinye izifundo zibonise ukuthi ukuthatha i-SAM njalo kungasiza ukulwa nokucindezeleka, isifo sesibindi, nobuhlungu be-osteoarthritis.Izivivinyo eziningi zomtholampilo zibonise ukuthi zilungele ukudangala, izifo ezithile zesibindi kanye ne-osteoarthritis.Zonke ezinye izimpawu azikaqinisekiswa.
5. Emtholampilo isetshenziselwa ukuthuthukisa ukusebenza kwesibindi.Inhlanganisela ne-L-DOPA yokwelapha isifo sika-Parkinson ingathuthukisa ukusebenza kwe-L-dopa futhi yehlise imiphumela engemihle.Ubuhlungu bendawo, ukukhathazeka kwesikhashana kanye nokuqwasha endaweni yomjovo kungabonakala.
I-S-Adenosyl-L-Methionine (i-Ademetionine; i-SAMe) (i-CAS: 29908-03-0) nayo inomphumela omuhle wokwelapha ku-arthritis, i-fibrous muscle, i-migraine nezinye izifo, futhi inomphumela omncane.Kusukela ngeminyaka yawo-1970, i-SAMe yayisetshenziswa njengomuthi kadokotela we-arthritis eYurophu.Ngo-1999, i-US FDA yagunyaza i-SAMe njengomkhiqizo wezempilo futhi isibe ngomunye wemikhiqizo yokudla okunempilo ethengiswa kakhulu e-United States.
I-S-Adenosyl-L-Methionine ilungiswa ngokuyinhloko yi-chemical synthesis, fermentation kanye nokuguqulwa kwe-enzymatic.Indlela yokuvubela iwukwengeza isandulela se-L-Methionine endaweni eyisisekelo equkethe imithombo ye-C ne-N, futhi inani elikhulu le-S-Adenosylmethionine lingatholwa ngokuhlakulela amangqamuzana amancane.Lona okwamanje umzila oyinhloko wokukhiqizwa kwezimboni ze-S-Adenosylmethionine.Phakathi kwazo, ama-microorganisms asetshenziselwa ukuvutshelwa angatholakala ngokuhlolwa noma izindlela zokwakha kabusha, eziqoshwe ezihlokweni eziningi kanye namalungelo obunikazi ekhaya nakwamanye amazwe.Ezinye izifundo zinikeze indlela yokulungiselela i-S-adenosylmethionine, kusetshenziswa ama-polyhydroxy organic reagents ukuvikela umsebenzi we-enzyme, kusetshenziswa i-adenosine triphosphate precursor, L-Methionine kanye nama-phosphate ions njengama-substrates, i-glucose noma/kanye ne-maltose njengabanikeli bamandla, enezela ukwakheka. ama-ion ensimbi, nokusebenzisa uhlobo lokukhiqiza oluvunyelekayo ukuze kukhuthazwe ukukhiqizwa kwe-S-Adenosylmethionine kuwo wonke amaseli.Ukusebenzisa ukwakheka kwama-ion ensimbi ukulawula ukugeleza kwe-metabolic ukuze kuthuthukiswe ukusebenza kahle kokuzihlanganisa kwamandla, ukwengeza ama-reagents e-organic ukuvikela umsebenzi wamabhaktheriya nama-enzyme, kusetshenziswa uhlobo lokukhiqiza oluvunyelekayo ukulungiselela i-S-Adenosylmethionine, ukunciphisa isikhathi sokuhlanganisa, futhi yenza umkhiqizo uqongelele ngaphandle kweseli, okungahle konga izindleko zokuhlukanisa okulandelayo futhi kube lula izinyathelo zokusebenza.
Ulwazi lokuphepha kwesikhathi eside kwe-S-Adenosyl-L-Methionine lukhawulelwe ngoba ababambiqhaza ocwaningweni oluningi bakuthathe isikhathi esifushane kuphela.Kodwa-ke, esifundweni esisodwa sesifo sesibindi esihlobene notshwala, abahlanganyeli bathatha i-S-Adenosyl-L-methionine iminyaka engu-2;kulolo cwaningo, akukho miphumela emibi kakhulu ebikiwe.
Abantu abane-bipolar disorder (isifo esibonakala ngokushintshashintsha kwemizwelo, kusukela ekucindezelekeni kuya kokusangana) akufanele bathathe i-SAMe ngezimpawu zabo zokucindezeleka ngaphandle kokugadwa umhlinzeki wezempilo ngoba i-SAMe ingase ibe yimbi kakhulu izimpawu ze-mania.
Nakuba i-S-Adenosyl-L-Methionine isetshenziselwe ukwelapha i-cholestasis ngesikhathi sokukhulelwa, ukuphepha kwayo ngesikhathi sokukhulelwa akukakasungulwa.
I-SAMe ingase yehlise imiphumela ye-levodopa (L-dopa), umuthi osetshenziselwa ukwelapha isifo sika-Parkinson.Kungenzeka futhi ukuthi i-SAMe ingase ihlanganyele nezidakamizwa nezithako zokudla ezikhuphula amazinga e-serotonin (ikhemikhali ekhiqizwa amaseli ezinzwa), njengama-antidepressants, i-L-tryptophan, ne-St. John's wort.
Kunokukhathazeka okungokwethiyori mayelana nokusetshenziswa kwe-SAMe ngabantu abangenawo amandla okuzivikela omzimba (njengalabo abane-HIV).Abantu abane-Immunocompromised basengozini yokutheleleka nge-Pneumocystis carinii, futhi i-SAMe ithuthukisa ukukhula kwale microorganism.
Imiphumela engemihle ye-SAMe ayivamile, futhi uma yenzeka ngokuvamile kuba yizinkinga ezincane ezifana nokucanuzela kwenhliziyo noma ukuphazamiseka kokugaya ukudla.
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