I-Afatinib Dimaleate CAS 850140-73-7 Purity >99.5% (HPLC) API

Incazelo emfushane:

Igama Lekhemikhali: Afatinib Dimaleate

Synonym: BIBW2992 Dimaleate

I-CAS: 850140-73-7

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Impushana Emhlophe ukuya Emhlophe

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	Afatinib Dimaleate
Omqondofana	BIBW2992 Dimaleate;(S,E)-N-(4-(3-Chloro-4-Fluorophenylamino)-7-(Tetrahydrofuran-3-yloxy)quinazolin-6-yl)-4-(dimethylamino)kodwa-2-Enamide Dimaleate
Inombolo ye-CAS	618-89-3
Inombolo yeCAT	I-RF-PI2032
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C32H33ClFN5O11
Isisindo samangqamuzana	718.08
Ukuzwela	Kuyazwela Umswakama
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe Kuya Kumhlophe
Ukuhlanzeka / Indlela Yokuhlaziya	>99.5% (HPLC)
Ukulahlekelwa Ekumisweni	<0.50%
Izinsalela ekushiseni	<0.10%
Ukungcola Okukodwa Okukhulu	<0.30%
Ukungcola Okuphelele	<0.50%
Izinsimbi Ezisindayo (njenge-Pb)	≤20ppm
I-Infrared Spectrum	Ivumelana Nesakhiwo
I-NMR	Ivumelana Nesakhiwo
Izinga Lokuhlola	I-Enterprise Standard
I-Shelf Life	Izinyanga Ezingu-24 Uma Zigcinwe Ngokufanelekile
Ukusetshenziswa	I-API

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-Afatinib Dimaleate (CAS: 850140-73-7), uhlobo lukasawoti oluyi-dimaleate lwe-afanitib, i-ejenti ye-antineoplastic etholakala ngomlomo.I-Afatinib Dimaleate iyi-EGFR inhibitor engabuyiseleki emuva enama-IC50s ka-0.5 nM, 0.4 nM, 10 nM kanye no-14 nM we-EGFRwt, EGFRL858R, EGFRL858R/T790M kanye ne-HER2, ngokulandelana.I-Afatinib Dimaleate ikhonjiswe ukwelashwa komugqa wokuqala weziguli ezinomdlavuza we-metastatic non-small cell lung cancer (NSCLC) amathumba azo anokususwa kwe-epidermal growth factor receptor (EGFR) exon 19 noma ukuguqulwa kwe-exon 21 (L858R) njengoba kutholwe yi-FDA- ukuhlolwa okugunyaziwe.Esikhathini esedlule, ukwelashwa okujwayelekile ngohlelo lwe-chemotherapy olusekelwe ku-platinum bekubhekwa njengokwelashwa okujwayelekile komugqa wokuqala kuzo zonke iziguli ezine-NSCLC.Kodwa-ke, ubufakazi obuvelayo buye bakhomba abantu abambalwa lapho ukwelashwa okuhlosiwe kusebenza kakhulu, okuholela ekwakhiweni kwezidakamizwa eziqondene nokuguquguquka.I-Afatinib Dimaleate Yasungulwa yi-Boehringer Ingelheim Pharmaceuticals, i-Afatinib Dimaleate yagunyazwa yi-FDA ngo-2013 njengesidakamizwa esiyintandane ngaphansi kwegama lokuhweba elithi Gilotrif.I-Afatinib Dimaleate ihlanganiswa ngamakhemikhali kusetshenziswa izindlela ezijwayelekile.Afatinib Dimaleateayisebenzi kuphela ngokumelene nokuguqulwa kwe-EGFR okuqondiswe i-TKI yesizukulwane sokuqala njenge-erlotinib noma i-gefitinib, kodwa futhi ngokumelene nokuguqulwa okufana ne-T790M engazweli kulezi zindlela zokwelapha ezijwayelekile.Ngenxa yomsebenzi wayo owengeziwe ngokumelene ne-Her2, kuphenywa umdlavuza webele kanye neminye imidlavuza eqhutshwa yi-EGFR kanye ne-Her2.