I-Afatinib Dimaleate Intermediate CAS 314771-76-1 Ubumsulwa >99.0% (HPLC) Isithombe Esifakiwe Sefektri

I-Afatinib Dimaleate Intermediate CAS 314771-76-1 Purity >99.0% (HPLC) Factory

Incazelo emfushane:

Igama Lekhemikhali: (S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine

I-CAS: 314771-76-1

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Impushana Ephuzi Ngokukhanyayo ukuya Ephuzi

I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine
Omqondofana	I-N4-(3-Chloro-4-Fluorophenyl)-7-[[(3S)-Tetrahydro-3-Furanyl]oxy] -4,6-Quinazolinediamine;I-Afatinib Ukungcola B;I-Afatinib-des(4-Dimethylamino-2-en-1-oxo)butyl;I-Des(4-Dimethylamino-2-en-1-oxo)butyl Afatinib
Inombolo ye-CAS	314771-76-1
Inombolo yeCAT	I-RF-PI2028
Isimo Sesitoko	Esitokweni, Amandla Okukhiqiza 100MT/Ngonyaka
I-Molecular Formula	I-C18H16ClFN4O2
Isisindo samangqamuzana	374.8
Iphuzu elibilayo	559.0±50.0℃
Ukuminyana	1.473±0.060 g/cm3
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Ephuzi Ekhanyayo ukuya Ephuzi
Ukuhlonza	Isikhathi Sokugcinwa Kwenani Eliphakeme Eliyinhloko ku-HPLC Kufanele Sihambisane Nezinga
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
Ukulahlekelwa Ekumisweni	<0.50%
Izinsalela ekushiseni	<0.20%
Ukungcola Okukodwa	<0.50%
Ukungcola Okuphelele	<1.00%
Izinsimbi Ezisindayo (njenge-Pb)	≤20ppm
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-Diamine (CAS: 314771-76-1) iphakathi kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib iyisizukulwane sesibili esinamandla futhi esingahlehliki inhibitor ekabili ye-epidermal growth factor receptor (EGFR) kanye ne-human epidermal growth factor receptor 2 (HER2) tyrosine kinase, eyakhiwe ngu-Boehringer Ingelheim, eJalimane.Iyakwazi ukuvimbela ngendlela engenakuhlehliswa umsebenzi we-tyrosine kinase ngokubhekana nokusabela kukaMichael neqembu le-thiol le-cysteine indawo engu-797 ye-EGFR.Umsebenzi: 1. NjengeLapatinib neNeratinib, i-Afatinib iyi-protein kinase inhibitor ephinde ivimbele ngendlela engenakulungiseka i-epidermal growth factor receptor 2 (Her2) kanye ne-epidermal growth factor receptor (EGFR) kinases.2. I-Afatinib ayisebenzi kuphela ngokumelene nokuguqulwa kwe-EGFR okuqondiswe i-TKI yesizukulwane sokuqala njenge-erlotinib noma i-gefitinib, kodwa futhi ngokumelene nokuguqulwa okufana ne-T790M engazweli kulezi zindlela zokwelapha ezijwayelekile.Ngenxa yomsebenzi wayo owengeziwe ngokumelene ne-Her2, kuphenywa umdlavuza webele kanye neminye imidlavuza eqhutshwa yi-EGFR kanye ne-Her2.3. I-Afatinib iwumuthi wokwelapha womugqa wokuqala weziguli ezinezinhlobo ezihlukile ze-metastatic (EGFR mutation positive) engeyona encane i-cell lung carcinoma (NSCLC).Isebenza njenge-covalent inhibitor engenakuhlehliswa ye-receptor tyrosine kinases epidermal growth factor receptor (EGFR) kanye ne-erbB-2 (HER2).