I-Afatinib Dimaleate Intermediate CAS 314771-88-5 Ubumsulwa >99.0% (HPLC) Isithombe Esifakiwe Sefektri

I-Afatinib Dimaleate Intermediate CAS 314771-88-5 Purity >99.0% (HPLC) Factory

Incazelo emfushane:

Igama Lekhemikhali: (S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine

I-CAS: 314771-88-5

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Okuphuzi ukuya kokuphuzi okukhanyayo

I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Intermediates ye-Afatinib
I-Afatinib CAS 439081-18-2
I-Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(I-Dimethylamino)i-acetaldehyde I-Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
I-Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4(1H)-one CAS 162012-69-3
I-7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S)-N4-(3-Chloro-4-Fluorophenyl)-7-((Tetrahydrofuran-3-yl)oxy)quinazoline-4,6-DiamineI-CAS 314771-76-1
(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-AmineI-CAS 314771-88-5

Chemical Properties:

Igama Lekhemikhali	(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine
Omqondofana	N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-[(3S)-oxolan-3-yl]oxyquinazolin-4-Amine;7-((S)-Tetrahydrofuran-3-yloxy)-4-(3-Chloro-4-Fluorophenyl)amino-6-Nitroquinazoline;Afatinib Ukungcola
Inombolo ye-CAS	314771-88-5
Inombolo yeCAT	I-RF-PI2027
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C18H14ClFN4O4
Isisindo samangqamuzana	404.78
Ukuminyana	1.534±0.060 g/cm3
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Ephuzi Okuphuzi
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
Ukulahlekelwa Ekumisweni	<0.50%
Ukungcola Ngamunye	<0.50%
Ukungcola Okuphelele	<1.00%
Izinsimbi Ezisindayo	≤20ppm
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-Intermediate ye-Afatinib Dimaleate (CAS: 850140-73-7)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

(S)-N-(3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl)oxy)quinazolin-4-Amine (CAS: 314771-88-5) isetshenziswa ukulungiswa kwe-Afatinib Dimaleate (CAS: 850140-73-7).I-Afatinib iyisidakamizwa esisha esihloselwe ukulwa nomdlavuza, isizukulwane esisha somuthi oqondiswe ngomlomo, umuthi wokuqala emhlabeni oqondiswe ukulwa nomdlavuza obophezela ngokungenakuhlehliswa emndenini we-ErbB, futhi osebenza kahle futhi ohlosiwe Ivimbela isignali ebangela ukukhula kwamangqamuzana omdlavuza. , ukunciphisa noma ukubambezela ukwanda kwamangqamuzana omdlavuza.I-Afatinib ingeyesigaba sezidakamizwa ezaziwa ngokuthi i-tyrosine kinase inhibitors.Isebenza ngokuvimbela umsebenzi wamaprotheni amabili ahlobene eduze, i-epidermal growth factor receptor (EGFR) kanye ne-human epidermal growth factor receptor 2 (HER2).Isetshenziselwa ukwelashwa komugqa wokuqala kweziguli ezinomdlavuza wamaphaphu we-metastatic ongewona omncane.I-Afatinib iyisidakamizwa esisha esihloselwe ukulwa nomdlavuza, isizukulwane esisha somuthi oqondiswe ngomlomo, umuthi wokuqala emhlabeni oqondiswe ukulwa nomdlavuza obophezela ngokungenakuhlehliswa emndenini we-ErbB, futhi osebenza kahle futhi ohlosiwe Ivimbela isignali ebangela ukukhula kwamangqamuzana omdlavuza. , ukunciphisa noma ukubambezela ukwanda kwamangqamuzana omdlavuza.