I-Anastrozole CAS 120511-73-1 API Factory High Quality
Ukunikezela Komkhiqizi Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Anastrozole
I-CAS: 120511-73-1
Igama | I-Anastrozole |
Omqondofana | I-Arimidex;α,α,α',α'-Tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl) -1,3-benzenediacetonitrile |
Inombolo ye-CAS | 120511-73-1 |
Inombolo yeCAT | I-RF-API74 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
I-Molecular Formula | I-C17H19N5 |
Isisindo samangqamuzana | 293.37 |
Ukuncibilika | I-Soluble ku-DMSO ne-Ethanol |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe |
Ukuhlonza A | I-IR/MS Ihambisana nezinga lokubhekisela |
Ukuhlonza B | I-HPLC kanye nesimo esiphezulu: Ihambisana nereferensi |
I-Melting Point | 81.0 ~ 84.0℃ |
Okuqukethwe kwamanzi (nge-KF) | ≤0.30% |
Izinsalela ekushiseni | ≤0.10% |
Ukulahlekelwa Ekumisweni | ≤0.50% |
Izinsimbi Ezisindayo | ≤10ppm |
Izinto Ezihlobene | |
Ukungcola A | ≤0.10% |
Ukungcola B | ≤0.20% |
Ukungcola C | ≤0.20% |
Ukungcola D | ≤0.10% |
Ukungcola E | ≤0.10% |
Okunye Ukungcola Okukodwa | ≤0.10% |
Ukungcola Okuphelele | ≤0.50% |
Izincibilikisi Ezisele | |
I-Cyclohexane | ≤0.30% |
I-Ethyl Acetate | ≤0.50% |
Isivivinyo | 98.0%~102.0% (komisiwe) |
I-Shelf Life | Izinyanga ezingama-24 |
Izinga Lokuhlola | Izinga lebhizinisi;I-United States Pharmacopoeia (USP) Standard |
Ukusetshenziswa | Ukwelapha Umdlavuza Webele |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
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I-Anastrozole (CAS 120511-73-1), iyi-non-steroidal, yesizukulwane sesithathu sokuphuma kwe-achiral triazole emakethe njenge-ARIMIDEX® yi-AstraZeneca Pharmaceuticals LP1.Ingenye yesizukulwane sesithathu se-aromatase inhibitor okuyi-inhibitor yokuncintisana kakhulu futhi ekhethiwe ye-aromatase, ngaleyo ndlela ivimbela ukuguqulwa kwe-testosterone ku-estradiol ne-androstenedione ku-estrone.Ukuvinjelwa kwe-enzyme ye-aromatase kwenzeka ikakhulukazi ngokuncintisana okubophezeleka kwe-aromatase ku-hemegroup ye-cytochrome P450, ukuncipha kwe-estrogen biosynthesis ezicutshini ezijikelezayo zomzimba nasesifubeni.
I-Anastrozole iyindlela yokwelapha ebekezelelwa kahle yomdlavuza webele osesigabeni sokuqala.Njengamanye ama-aromatase inhibitors, umphumela wawo omubi obaluleke kakhulu kwaba ingozi eyengeziwe yokuphuka kwamathambo, okuthi i-anastrozole ivinjelwe esikhathini sokwelashwa.Inobuthi obuncane uma iqhathaniswa nokwelashwa ngamakhemikhali;kodwa-ke, kuye kwaphawulwa ukuthi iziguli eziningi ezilashwa nge-anastrozole zikhala ngezimpawu ezihlangene kunalokho obekulindelwe, ikakhulukazi ukuqina kwedijithali okufana ne-rheumatoid arthritis.Ezinye izivivinyo zomtholampilo ze-anastrozole kwabesifazane abangemva kokuya esikhathini abanomdlavuza webele eYurophu nase-United States babike ukuphazamiseka kwemisipha njengezehlakalo ezimbi.I-Anastrozole (i-Arimidex®) iyi-aromatase inhibitor evunyelwe e-EU, e-US nakwamanye amazwe emhlabeni jikelele ukuze isetshenziswe njengokwelashwa kwe-adjuvant kwabesifazane abangemva kokuya esikhathini abanomdlavuza webele we-hormone receptor-positive.Igunyazwe futhi e-EU nakwamanye amazwe emhlabeni jikelele ngokuqhubeka nokwelashwa kwe-adjuvant kwabesifazane asebevele beneminyaka engu-2-3 yokwelashwa kwe-adjuvant tamoxifen yomdlavuza webele.
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