I-Apixaban CAS 503612-47-3 Purity ≥99.5% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Apixaban (CAS: 503612-47-3) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Apixaban,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Apixaban |
| Omqondofana | 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine -3-carboxamide, 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-7-oxo-6-[4-(2-oxo-1-piperidinyl)phenyl]-1H-pyrazolo[3, 4-c]pyridine-3-carboxamide, BMS 562247, BMS-562247 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 503612-47-3 |
| I-Molecular Formula | I-C25H25N5O4 |
| Isisindo samangqamuzana | 459.51 g/mol |
| I-Melting Point | 235.0~238.0℃ |
| Ukuminyana | 1.42 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-API |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | I-Crystalline Powder emhlophe ukuya kokumhlophe | Iyahambisana |
| Ukulahlekelwa Ekumisweni | ≤0.50% | 0.10% |
| Izinsalela ekushiseni | ≤0.10% | 0.08% |
| Izinsimbi Ezisindayo (njenge-Pb) | ≤20ppm | Iyahambisana |
| Izinto Ezihlobene | ||
| Noma Ikuphi Ukungcola Okukodwa | ≤0.50% | Iyahambisana |
| Ukungcola Okuphelele | ≤0.50% | Iyahambisana |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.5% (HPLC) | 99.9% |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| 1 H NMR Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nezicaciso | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Awukho umkhiqizo ozohlinzekwa emazweni lapho lokhu kungase kungqubuzane namalungelo obunikazi akhona.Nokho umthwalo wokugcina ukumthengi.
Okokusetshenziswa kocwaningo lwesayensi kuphela, hhayi ngenjongo yokuthengisa, hhayi ukusetshenziswa komuntu noma ukuxilonga.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-Apixaban (i-CAS: 503612-47-3) iwuhlobo olusha lwesidakamizwa somlomo se-anticoagulant esakhiwe nguBristol Myers Squibb noPfizer.Iwuhlobo olusha lwe-oral Xa factor inhibitor, futhi igama layo lezentengiso i-Eliquis.I-Apixaban isetshenziselwa ukwelapha iziguli ezikhulile ezihlinzwa ngokukhethwa kwe-hip noma idolo ukuze kuvinjelwe i-venous thromboembolism (VTE)
I-Apixaban (i-CAS: 503612-47-3) iyi-inhibitor ekhethiwe ngomlomo eyenziwe yasebenza futhi ingavimbela ukukhiqizwa kwe-thrombin kanye ne-thrombosis.
I-Apixaban (i-CAS: 503612-47-3) iyi-anticoagulant yomlomo yesithathu entsha ezothengiswa, ilandela i-dabigatran ne-rivaroxaban, futhi isivele ivunyelwe eYurophu ukuvimbela i-venous thromboembolism ezigulini ezihlinzwa ukuguqulwa kwe-hip noma idolo.Kulawa ma-anticoagulants amathathu omlomo avunywe eYurophu, uma kuqhathaniswa nokwelashwa okujwayelekile kwamanje kokuvimbela i-venous thromboembolism, i-enoxaparin, i-rivaroxaban iphumelele ekuhlolweni kwerekhodi, futhi i-apixaban iphumelele ekuhlolweni kwangaphambili.Imiphumela yokwelapha ye-Rivaroxaban yayiphakeme kancane, kodwa yabangela ukopha okukhulu kakhulu kune-apixaban.Abacwaningi bathi lokhu kuhluka ngesikhathi somuthi, njengoba i-rivaroxaban ithathwe amahora angu-6-8 ngemva kokuhlinzwa ekuhlolweni kwerekhodi, kuyilapho i-apixaban isetshenziswe amahora angu-18 ngemva kokuhlinzwa ekuhlolweni kwangaphambili.Le mishanguzo inomphumela ongcono wokwelapha lapho isetshenziswa sekusondele isikhathi sokuhlinzwa, kodwa futhi inengozi yokopha eyandayo.Ucwaningo lwezokwelapha lubonise ukuthi uma kuqhathaniswa nomjovo we-subdermal wansuku zonke we-40mg enoxaparin, imithamo ye-2 yomlomo ye-2.5mg ye-apixaban ibe nemiphumela engcono yokuvimbela ngokumelene ne-venous thromboembolism elandela ukuhlinzwa esikhundleni se-hip noma idolo futhi ayizange ikhulise ingozi yokopha.
I-Apixaban (i-CAS: 503612-47-3) iwuhlobo olusha lwe-oral Xa factor inhibitor ehlanganiswe ngokuhlanganyela yi-Bristol-Myers Squibb kanye ne-Pfizer.Igama lokuhweba i-eratol, okuwuhlobo olusha lwe-anticoagulant yomlomo.Ngokuvimbela i-coagulation factor ebalulekile Xa, i-apixaban ingavimbela ukukhiqizwa kwe-thrombin kanye ne-thrombosis.Ngomhla zingama-26 kuMbasa wezi-2007, uBristol-Myers Squibb wajoyina izandla noPfizer ukuze bamemezele ukubambisana ekuthuthukisweni kwe-apixaban yomlomo entsha ye-anticoagulant ephethwe yiBristol-Myers Squibb njengenye indlela ethuthukisiwe ye-warfarin.Ngokwesivumelwano sokubambisana, i-Pfizer izokhokha inkokhelo kusengaphambili engu-US $0.25 billion kuBristol-Myers Squibb ukuze ithwale u-60% wezindleko eziphelele zokuthuthukiswa kwe-anticoagulant apixaban (ezoqaliswa kusukela ngoJanuwari 1, 2007), kuyilapho iBristol-Myers. I-squibb izothwala u-40% osele, ngaleyo ndlela ithole ilungelo lokuthuthukisa ngokuhlanganyela nokuthengisa umuthi.Ngo-May 2011, i-apixaban yaba ngowokuqala ukugunyaza ukuvinjelwa kwe-venous thrombosis ezigulini ezikhulile ezenza ukuhlinzwa okukhethwa kukho kwe-hip noma idolo emazweni e-27 EU, e-Iceland naseNorway.Ngomhla ka-November 20, i-2012, i-European Commission yavuma i-Ererto (i-apixaban) yokuvimbela isifo sohlangothi kanye ne-systemic embolism ezigulini ezikhulile ezine-non-valvular atrial fibrillation (NVAF) enesici esisodwa noma ngaphezulu engozini.Kamuva, i-Canadian Food and Drug Administration, Japan, kanye ne-US FDA igunyaze u-Ererto?(i-apixaban) yokuvimbela isifo sohlangothi kanye ne-systemic embolism ezigulini ezikhulile ezine-non-valvular atrial fibrillation (NVAF) enesici esisodwa noma ngaphezulu engozini.Ngo-Ephreli 12, 2013, umuthi omusha we-anticoagulant Eloto (ELIQUIS)(apixaban) owakhiwe ngokuhlanganyela yiBristol-Myers Squibb kanye noPfizer wamenyezelwa ngokusemthethweni ukuthi uzofakwa ohlwini e-China.I-Ererto iyinoveli ye-oral factor Xa inhibitor yokuvimbela i-venous thromboembolism (VTE) ezigulini ezikhulile ezithatha indawo ye-hip noma yamadolo.Ukufakwa ohlwini kunikeza ukhetho olusha oluphephile nolusebenzayo lwe-anticoagulation yomtholampilo ngemva kokuhlinzwa kwamathambo, futhi kuletha izindaba ezinhle ezigulini zaseShayina ezishintshwa ngokukhethwa kwe-hip/edolo.Ucwaningo lwezokwelapha luye lwaqinisekisa ukuthi uma kuqhathaniswa ne-40mg enoxaparin kanye ngosuku, izikhathi ezi-2 ngosuku ukuphathwa komlomo kwe-eratol?(i-apixaban) i-2.5mg iphumelela kakhulu ekuvimbeleni i-thromboembolism ye-venous ngemva kokuhlinzwa kwe-hip noma idolo, futhi ayikhulisi ingozi yokopha.Umfanekiso 1 ubonisa amaphilisi e-Elotoapixaban akhiqizwa i-Bristol-Myers Squibb kanye ne-Pfizer.
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