I-Atazanavir CAS 198904-31-3 Purity ≥99.0% API Factory Anti-HIV HIV-1 Protease Inhibitor

I-Atazanavir (CAS 198904-31-3) iyisidambisigciwane, inoveli kanye nomuthi we-azapeptide onamandla wesigaba se-protease inhibitor (PI).Ithengiswa ngaphansi kwegama lokuhweba elithi Reyataz.Njengezinye izidambisigciwane, isetshenziselwa ukwelapha ukutheleleka kwe-human immunodeficiency virus type 1 (HIV-1) protease enzyme ene-inhibition engaguquki i-Ki engu-66 nmol/L futhi ivimbela ukuphindaphindeka kwegciwane le-HIV-1 ngo-50% wokuhlushwa okusebenzayo kwe-EC50 kusukela 2.6 kuya ku-5.3 nmol/L.I-Atazanavir ibophezela ku-HIV-1 protease ivimbela ukuqhekeka kwe-gag ne-gag-pol polyprotein, okuholela ekwakhekeni kwama-virion angavuthiwe kumaseli ane-HIV-1.I-Atazanavir inokwakheka kwamakhemikhali alinganayo e-C-2 kanye namandla e-antiretroviral amaningi ngokuvamile ezinhlotsheni ezihlukahlukene ze-HIV uma kuqhathaniswa namanye ama-protease inhibitors, okuhlanganisa i-Indinavir, i-Nelfinavir, i-Ritonavir, i-Saquinavir ne-Amprenavir.I-Atazanavir ihlukaniswa kwamanye ama-PIs ngoba inganikezwa kanye ngosuku futhi inemiphumela emincane kuphrofayili ye-lipid yesiguli.Njengamanye ama-protease inhibitors, isetshenziswa kuphela ngokuhlangana neminye imithi ye-HIV.I-Atazanavir iyinoveli ye-azapeptide HIV protease inhibitor.I-Antiviral.Ithathwa ngomlomo kanye ngosuku.