I-Atazanavir CAS 198904-31-3 Purity ≥99.0% API Factory Anti-HIV HIV-1 Protease Inhibitor
Nikeza Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Atazanavir
CAS: 198904-31-3
I-HIV-1 Protease Inhibitor
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Atazanavir |
Omqondofana | I-BMS-232632 |
Inombolo ye-CAS | 198904-31-3 |
Inombolo yeCAT | I-RF-API70 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
I-Molecular Formula | I-C38H52N6O7 |
Isisindo samangqamuzana | 704.86 |
I-Melting Point | 207.0~209.0℃ |
Ukuncibilika | I-Soluble ku-DMSO;Ayincibiliki Emanzini |
Isitoreji Sesikhathi Eside | Gcina Isikhathi Eside ku -20 ℃ |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Emhlophe |
Ifomu | Isisekelo samahhala |
Ukulahlekelwa Ekumisweni | ≤0.50% |
Izinsalela ekushiseni | ≤0.20% |
Izinsimbi Ezisindayo | ≤20ppm |
Ukungcola A | ≤0.10% |
Ukungcola B | ≤0.10% |
Ukungcola Okukodwa | ≤0.20% |
Ukungcola Okuphelele | ≤1.0% |
Ukuhlanzeka/Ukuhlaziya Indlela | ≥99.0% (HPLC) |
pH | 5.0~8.0 |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-HIV-1 Protease Inhibitor Anti-HIV |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, I-Cardboard Drum, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
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I-Atazanavir (CAS 198904-31-3) iyisidambisigciwane, inoveli kanye nomuthi we-azapeptide onamandla wesigaba se-protease inhibitor (PI).Ithengiswa ngaphansi kwegama lokuhweba elithi Reyataz.Njengezinye izidambisigciwane, isetshenziselwa ukwelapha ukutheleleka kwe-human immunodeficiency virus type 1 (HIV-1) protease enzyme ene-inhibition engaguquki i-Ki engu-66 nmol/L futhi ivimbela ukuphindaphindeka kwegciwane le-HIV-1 ngo-50% wokuhlushwa okusebenzayo kwe-EC50 kusukela 2.6 kuya ku-5.3 nmol/L.I-Atazanavir ibophezela ku-HIV-1 protease ivimbela ukuqhekeka kwe-gag ne-gag-pol polyprotein, okuholela ekwakhekeni kwama-virion angavuthiwe kumaseli ane-HIV-1.I-Atazanavir inokwakheka kwamakhemikhali alinganayo e-C-2 kanye namandla e-antiretroviral amaningi ngokuvamile ezinhlotsheni ezihlukahlukene ze-HIV uma kuqhathaniswa namanye ama-protease inhibitors, okuhlanganisa i-Indinavir, i-Nelfinavir, i-Ritonavir, i-Saquinavir ne-Amprenavir.I-Atazanavir ihlukaniswa kwamanye ama-PIs ngoba inganikezwa kanye ngosuku futhi inemiphumela emincane kuphrofayili ye-lipid yesiguli.Njengamanye ama-protease inhibitors, isetshenziswa kuphela ngokuhlangana neminye imithi ye-HIV.I-Atazanavir iyinoveli ye-azapeptide HIV protease inhibitor.I-Antiviral.Ithathwa ngomlomo kanye ngosuku.
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