I-Bacitracin Zinc CAS 1405-89-6 Potency ≥70 IU/mg Peptide Antibiotic Factory
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo kanye nomphakeli we-Bacitracin Zinc (Zinc Bacitracin) (CAS: 1405-89-6) enekhwalithi ephezulu.Singahlinzeka nge-COA, ukulethwa komhlaba wonke, amanani amancane kanye nenqwaba etholakalayo.Uma unentshisekelo ku-Bacitracin Zinc (Zinc Bacitracin),Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Bacitracin Zinc |
| Omqondofana | I-Bacitracin Zinc Usawoti;I-Zinc Bacitracin |
| Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani ayi-10 ngonyaka |
| Inombolo ye-CAS | 1405-89-6 |
| I-Molecular Formula | I-C66H101N17O16SZn |
| Isisindo samangqamuzana | 1486.07 |
| I-Melting Point | 250 ℃(dec.) |
| Ukuncibilika kwamanzi | 5.1 g/L |
| I-COA ne-MSDS | Iyatholakala |
| Isampula | Iyatholakala |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impunga Emhlophe noma Ekhanyayo Ephuzi-Empunga noma E-Beige | Kuyavumelana |
| Ukuhlonza | Hlangana Nezimfuneko | Kubonakala Ukusabela Okuhle |
| pH | 6.0~7.5 | 7.1 |
| Ukulahlekelwa Ekumisweni | ≤5.0% | 2.7% |
| I-Zinc (Into Eyomisiwe) | 4.0%~6.0% | 4.20% |
| Amandla | ≥70 IU/mg Microbial Assay (Isisekelo Esomisiwe) | 71 IU/mg |
| Okuqukethwe kwe-Bacitracin A | ≥40.0% | 58.2% |
| Okuqukethwe kwe-Active Bacitracin | ≥70.0% (i-Bacitracin A, B1, B2, ne-B3) | 86.1% |
| Umkhawulo we-Eluting Peptides Wakuqala | ≤20.0% | 7.6% |
| Umkhawulo we-Bacitracin F | ≤6.0% | 1.1% |
| Isamba Sesibalo Se-Aerobic Esisebenzayo | <100 CFU/gram | Kuyavumelana |
| Isiphetho | Umkhiqizo Uvumelana Namazinga E-USP44 | |
| Ukusetshenziswa Okuyinhloko | I-Peptide Antibiotic | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
I-Bacitracins, i-zinc complex.
I-Bacitracins zinc complex [1405-89-6].
» I-Bacitracin Zinc inxanxathela ye-zinc ye-bacitracin, equkethe ingxube ye-polypeptides elwa namagciwane, izingxenye eziyinhloko okuyi-bacitracins A, B1, B2, kanye ne-B3.Inamandla angekho ngaphansi kwama-Bacitracin Units angama-65 mg, abalwe ngokomisiwe.Iqukethe amaphesenti angekho ngaphansi kwamaphesenti angu-4.0 futhi angabi ngaphezu kwamaphesenti angu-6.0 we-zinc (Zn), ebalwa ngesisekelo esomisiwe.
Ukupakisha nokugcina- Gcina ezitsheni eziqinile, futhi ugcine endaweni epholile.
Ilebula-Ifake ilebula ukukhombisa ukuthi izosetshenziswa ekwenzeni izidakamizwa ezingezona ezabazali kuphela.Lapho ipakishwe ukuze ihlanganiswe nencwadi kadokotela, ilebula ukuze ubonise ukuthi ayinyumba nokuthi amandla angeke aqinisekiswe isikhathi esingaphezu kwezinsuku ezingama-60 ngemva kokuvulwa, futhi usho inani lamayunithi e-Bacitracin ngemiligremu ngayinye.Lapho ihloselwe ukusetshenziswa ekulungiseni amafomu omthamo oyinyumba, ilebula ithi ayinyumba noma kufanele iqhubeke nokucutshungulwa ngesikhathi sokulungiswa kwamafomu omthamo oyinyumba.
Amazinga ereferensi we-USP <11>-
I-USP Bacitracin Zinc RS
Ukuhlonza-
A: Ukuhlolwa Kokuhlonza Kwe-Chromatographic-Thin-Layer <201BNP>: kuhlangabezana nezimfuneko.
B: Ihlangabezana nezimfuneko zenqubo ye-chromatographic ewuketshezi ekuhlolweni Kokwakheka.
I-Sterility <71>-Lapho ilebula ithi ayinyumba, ihlangabezana nezimfuneko lapho ihlolwa njengoba kuqondiswe Ekuhluzweni Kwe-Membrane ngaphansi Kokuhlolwa Kobunyumba Bomkhiqizo okufanele Uhlolwe, ngaphandle kokusebenzisa i-Fluid A ku-L ngayinye engezwe 20 g ye-edetate disodium.
i-pH <791>: phakathi kuka-6.0 no-7.5, kwisisombululo (esigcwele) esiqukethe cishe u-100 mg ngemL ngayinye.
Ukulahlekelwa ekumisweni <731>-Yomisa cishe u-100 mg ebhodleleni eline-capillary-stoppered ku-vacuum ngo-60 amahora angu-3: alahlekelwa ngaphezu kuka-5.0% wesisindo sawo.
Okuqukethwe kwe-Zinc- [inothi-Amalungiselelo Ajwayelekile kanye namalungiselelo Okuhlola angase ahlanjululwe ngokomthamo nge-0.001 N hydrochloric acid, uma kunesidingo, ukuze kutholwe izixazululo zokugxilisa okufanelekile, ezivumelana nomugqa noma uhla lokusebenza lwethuluzi.]
Amalungiselelo ajwayelekile-Dlulisa u-3.11 g we-zinc oxide, ukalwe ngokunembile, ku-250-mL ye-volumetric flask, engeza u-80 mL we-1 N hydrochloric acid, efudumele ukuze incibilike, ipholile, ihlanjululwe ngamanzi ngevolumu, bese uxuba.Lesi sixazululo siqukethe u-10 mg we-zinc nge-mL ngayinye.Hlanza futhi lesi sixazululo ngo-0.001 N hydrochloric acid ukuze uthole amalungiselelo Ajwayelekile aqukethe u-0.5, 1.5, no-2.5 µg we-zinc nge-mL ngayinye, ngokulandelanayo.
Ukulungiselela ukuhlolwa-Dlulisa cishe u-200 mg we-Bacitracin Zinc, ukalwe ngokunembile, uye kuflask yevolumu ye-100-mL.Chaza ku-0.01 N hydrochloric acid, hlambulula nge-solvent efanayo kuvolumu, bese uxuba.Pipetha u-2 mL walesi sixazululo ku-200-mL ye-volumetric flask, hlambulula nge-0.001 N hydrochloric acid kuvolumu, bese uxuba.
Inqubo-Nquma kanyekanye ukumunca kwamalungiselelo Ajwayelekile kanye nokulungiswa kokuhlolwa kulayini we-zinc resonance engu-213.8 nm, ene-spectrophotometer yokumuncwa kwe-athomu efanelekile (bona i-Spectrophotometry and Light-scattering <851>), efakwe isibani se-zinc hollow-cathode kanye ilangabi lomoya-acetylene, lisebenzisa i-0.001 N hydrochloric acid njengento engenalutho.Hlela ukumunca kwamalungiselelo Ajwayelekile uma uqhathanisa nokugxilisa ingqondo, ku-µg nge-mL ngayinye, ye-zinc, bese udweba umugqa oqondile ofanele amaphuzu amathathu ahleliwe.Kusuka kugrafu etholiwe, thola ukugcwala, ku-µg ngemL ngayinye, ye-zinc ekulungiseleleni Ukuhlola.Bala okuqukethwe kwe-zinc, ngamaphesenti, engxenyeni ye-Bacitracin Zinc ethathwe ifomula:
1000C / W
lapho u-C eyingqikithi ku-µg ngemL ngayinye, ye-zinc ekulungiselelweni kokuhlolwa;futhi u-W yisisindo, ngo-mg, sengxenye ye-Bacitracin Zinc ethathiwe.
Ukwakhiwa-
I-Buffer- Chaza u-34.8 g we-potassium phosphate, i-dibasic, ku-1 L yamanzi.Lungisa nge-27.2 g ye-potassium phosphate, i-monobasic, encibilikiswe ku-1 L yamanzi, ku-pH engu-6.0.
I-Mobile Phase-Lungiselela ingxube ye-methanol, amanzi, i-Buffer, ne-acetonitrile (26:15:5:2).Hlanganisa kahle, futhi degas.
I-Diluent-Diluent 40 g ye-edetate disodium ku-1 L yamanzi.Lungisa nge-sodium hydroxide exubile ibe yi-pH engu-7.0.
Isixazululo sokufaneleka kwesistimu-Chaza isamba esikalwe ngokunembile se-USP Bacitracin Zinc RS ku-Diluent ukuze uthole isixazululo esinokugxiliswa okulinganiselwe okungaba ngu-2.0 mg nge-mL ngayinye.
Ukubika isixazululo se-threshold-Hlanganisa ngobuningi, ngamanzi, umthamo ofanele wesixazululo sokufaneleka kweSistimu ukuze uthole isixazululo ngokuhlushwa okwaziwayo okungu-0.01 mg ngemL ngayinye.
Isixazululo sokuhlonza isiqongo-Chaza inani elikaliwe le-USP Bacitracin Zinc RS ngevolumu efanelekile ye-Diluent ukuze uthole isixazululo esinokugxila okulinganiselwe okungaba ngu-2.0 mg nge-mL ngayinye.Shisisa emanzini okugeza abilayo imizuzu engama-30.Kuphole ekamelweni lokushisa.
Isixazululo sokuhlola-Chaza inani elinembile lesisindo se-Bacitracin Zinc ku-Diluent ukuze uthole isixazululo esinengxube encane engaba ngu-2.0 mg nge-mL ngayinye.
Isistimu ye-Chromatographic (bona i-Chromatography <621>)-I-chromatograph ewuketshezi ifakwe umtshina wokumunca kanye nekholomu ene-end-capped 4.6- × 250-mm equkethe 5-µm ukupakisha L1.Izinga lokugeleza ngu-1.0 mL ngomzuzu.Setha ubude begagasi bomtshina ku-300 nm.Jova cishe u-100 µL wesisombululo sokuhlonza Esiphakeme, uphinde uhlonze indawo ye-bacitracin F, okuwukungcola okwaziwayo, usebenzisa isikhathi sokugcina esihlobene esiboniswe kuThebula 1.
Ithebula 1
Isikhathi Sokugcina Esihlobene Segama Lengxenye (cishe)
I-Bacitracin C1 0.5
I-Bacitracin C2 0.6
I-Bacitracin C3 0.6
I-Bacitracin B1 0.7
I-Bacitracin B2 0.7
I-Bacitracin B3 0.8
I-Bacitracin A 1.0
I-Bacitracin F 2.4
Shintsha ubude begagasi bomtshina bese uwubeka ku-254 nm.I-Chromatograph isixazululo sokufaneleka kweSistimu, futhi urekhode izimpendulo eziphakeme njengoba kuqondiswe kuNqubo: thola iziqongo zezingxenye ezisebenza kakhulu ze-bacitracin (i-bacitracins A, B1, B2 ne-B3), ama-peptide asheshayo (lawo adlula ngaphambi kokuphakama ngenxa ye-bacitracin B1 ) nokungcola, i-bacitracin F, kusetshenziswa amanani esikhathi sokugcina ahlobene anikezwe kuThebula 1. Bala isilinganiso se-peak-to-valley usebenzisa ifomula:
Hp / HV
lapho i-Hp iwukuphakama ngaphezu kwesisekelo sesiqongo ngenxa ye-bacitracin B1;futhi i-HV iwubude obungaphezu kwesisekelo sephuzu eliphansi kakhulu lejika elihlukanisa isiqongo se-bacitracin B1 nesiqongo ngenxa ye-bacitracin B2.Isilinganiso se-peak-to-valley ayikho ngaphansi kuka-1.2.
Inqubo-Ngokuhlukile jova amavolumu alinganayo (100 µL) we-Diluent, isixazululo sokuhlola, nesixazululo somkhawulo wokubika.Rekhoda ama-chromatogram cishe izikhathi ezintathu zesikhathi sokugcinwa kwe-bacitracin A. Thola iziqongo usebenzisa izikhathi zokugcinwa ezilinganiselwe eziboniswe kuThebula 1. Linganisa izindawo eziphakeme zazo zonke iziqongo kwisixazululo sokuhlola.[Qaphela-Unganaki noma yikuphi ukuphakama kwesixazululo sokuhlola esinendawo engaphansi kwendawo ye-bacitracin A ephakeme kusixazululo somkhawulo wokubika;ungayinaki noma yiliphi inani eliphakeme elibonwa ku-Diluent.]
inothi-Ingqikithi yendawo ezibalweni ezilandelayo ichazwa njengendawo yazo zonke iziqongo ngaphandle komkhawulo wokubika.
okuqukethwe kwe-bacitracin a-Bala iphesenti le-bacitracin A usebenzisa ifomula:
(rA / Indawo ephelele) × 100
lapho i-rA iyimpendulo yendawo evela ku-bacitracin A. Okuqukethwe kwe-Bacitracin A akukho ngaphansi kuka-40.0% wendawo Ephelele.
okuqukethwe kwe-bacitracin esebenzayo-Bala iphesenti le-bacitracin esebenzayo (i-bacitracin A, B1, B2, ne-B3) usebenzisa ifomula:
(rA + rB1 + rB2 + rB3 / Indawo ephelele)×100
lapho i-rA, i-rB1, i-rB2, ne-rB3 kuyizimpendulo zendawo ezivela ku-bacitracin A, B1, B2, ne-B3, ngokulandelana.Isamba se-bacitracin A, B1, B2, ne-B3 alikho ngaphansi kuka-70.0% wendawo Ephelele.
umkhawulo wama-peptide asheshayo-Bala amaphesenti azo zonke iziqongo ezidlulayo ngaphambi kwenani eliphakeme ngenxa ye-bacitracin B1 usebenzisa ifomula:
(rPreB1 / Indawo ephelele) ×100
lapho i-rPreB1 iyisamba sezimpendulo zazo zonke iziqongo ezidlulayo ngaphambi kwenani eliphakeme le-bacitracin B1.Umkhawulo wama-peptide asheshayo (lawo adlula ngaphambi kokuphakama ngenxa ye-bacitracin B1) awukho ngaphezu kuka-20.0%.
umkhawulo we-bacitracin f- Bala iphesenti le-bacitracin F usebenzisa ifomula:
100 × (rF / rA)
lapho i-rF iyimpendulo ye-bacitracin F evela kusixazululo sokuhlola;futhi i-rA iyimpendulo ye-bacitracin A evela kusixazululo sokuhlola.Umkhawulo we-bacitracin F, ukungcola okwaziwayo, awukho ngaphezu kuka-6.0%.
I-Assay-Qhubeka nge-Bacitracin Zinc njengoba kuqondiswe ngaphansi kwe-Antibiotics-Microbial Assays 81.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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I-HS Code 2941909099
I-Bacitracin ikhishwa kusixazululo se-culture of lichen (Bacillus licheniformis) futhi iyisibulala-magciwane se-polypeptide.Impushana emhlophe noma ekhanyayo ephuzi, engenaphunga noma enephunga kancane, ukunambitheka okubabayo, i-hygroscopic.Ukuncibilika kalula emanzini kanye ne-ethanol, isixazululo esingazinzile, esinamanzi asisebenzi kalula ekamelweni lokushisa, asizinzile ku-pH 9, futhi kufanele sifakwe esiqandisini ngemva kokuqedwa.Lo mkhiqizo ubalwa njengomkhiqizo owomile, futhi i-titer nge-milligram akufanele ibe ngaphansi kwamayunithi angama-bacitracin angama-55.I-Bacitracin zinc ingusawoti we-bacitracin zinc, ozinzile kune-bacitracin.Isetshenziswa njengesengezo sokudla futhi inemisebenzi yokukhuthaza ukukhula nokuthuthukiswa kwemfuyo nezinkukhu, ukuvimbela izifo zamathumbu, nokwandisa iholo lokudla.Umthamo uyafana ne-bacitracin.I-Bacitracin antibacterial spectrum iyafana ne-penicillin, enomphumela onamandla wokulwa namagciwane kubhaktheriya e-gram-positive futhi engenawo umthelela osobala kumagciwane angenayo igram.Ngezifo ezinzima ze-Staphylococcus aureus ezingazweli emthini.Ukuphathwa ngomlomo akumuncwa futhi kusetshenziselwa izifo zamathumbu.Ukusetshenziswa kwangaphandle futhi kuyasebenza ebusweni bomzimba, izifo zomlomo nezamehlo kanye ne-mastitis ebangelwa amagciwane azwelayo.Inomthelela olimazayo ezinso.I-Bacitracin zinc isetshenziswe njengesengezo somuthi wokuphakelayo.Ukuphatha ngomlomo akumuncwe neze, ngakho ngokuvamile kunenkolelo yokuthi ayikho inkinga yezinsalela zezidakamizwa emfuyweni nasezinkukhuni.Lo mkhiqizo uyisibulala-magciwane esine-spectrum esincane, esinomthelela onamandla we-antibacterial kuma-bacteria amaningi e-gram-positive.Iphinde isebenze ngokumelene ne-spirochetes kanye ne-actinomycetes, kodwa ayisebenzi ngokumelene namagciwane angenayo igram.Inomphumela we-synergistic nezinhlobonhlobo zemithi elwa namagciwane njenge-penicillin G, i-streptomycin, i-neomycin, i-polymyxin, njll. Usawoti wayo we-zinc usetshenziswa kakhulu njengesithasiselo sokuphakelayo, esinemisebenzi yokuvimbela ukutheleleka kwamathumbu, ukukhuthaza ukukhula nokuthuthukisa inkokhelo yokudla.Amagciwane angakhula kancane kancane ukumelana nalo mkhiqizo, kodwa akukho ukumelana phakathi kwalo mkhiqizo namanye ama-antibiotic.Lo mkhiqizo unobuthi kakhulu futhi awukwazi ukujovwa.Ingathathwa ngomlomo ukwelapha isifo sohudo esibangelwa amagciwane emfuyweni kanye ne-Treponema dysentery ezingulubeni.Ngokomtholampilo, kuvame ukusetshenziswa ngokuhambisana nezinhlobonhlobo zemithi elwa namagciwane njenge-penicillin, i-streptomycin, i-neomycin, i-polymyxin B, njll. ukuze kuthuthukiswe ukusebenza kahle.
I-Bacitracin Zinc iyinkimbinkimbi eyakhiwe yi-bacitracin nama-zinc ions.iyisibulala-magciwane se-polypeptide futhi iyisengezo sokuphakela kwamagciwane esisetshenziswa kakhulu okwamanje.okuqukethwe kwe-zinc ngokuvamile ku-2% ~ 12%.Imikhiqizo yokwenziwa iyimpushana emhlophe noma ephuzi, enephunga elikhethekile, kulula ukuncibilika ibe yizinto ezine-alkali ebuthakathaka, futhi incibilika kalula emanzini, i-methanol ne-ethanol.I-Bacitracin zinc inomphumela oqinile we-antibacterial ngokumelene namagciwane e-Gram-positive, futhi inezici zokulwa namagciwane ngokumelene namagciwane athile angenayo i-Gram-negative.Ukusetshenziswa kwe-bacitracin zinc ekudleni kwenani eligcwele lezingulube kungakhuthaza izinga lokukhula, kuthuthukise inkokhelo yokudla, futhi kuvimbele isifo sohudo esibangelwa amagciwane ezingulube kanye nezifo zokuphefumula ezingapheli.Ukugxila okungeziwe kuvamise ukuba ngu-10~100mg/kg, futhi umphumela awuthuthukisiwe kakhulu ngale kobubanzi bokwengezwa.I-Bacitracin Zinc ngokuvamile ayimuncwe emathunjini engulube, ngakho-ke ayikho inkinga yezinsalela.Kuyisithasiselo se-antibiotic esiphephile nesithembekile.I-Bacitracin Zinc inobuthi obuphezulu futhi ayimuncwe kalula amathumbu, ngakho ayikwazi ukusetshenziswa njengokwelapha izifo zesistimu.
Ama-antibiotic e-Polypeptide anomphumela oqinile we-antibacterial ku-bacterium ye-gram-positive, futhi anomthelela wokulwa namagciwane kumagciwane ambalwa angenayo igram-negative, ama-spirochetes, i-actinomycetes ngisho ne-penicillin-resistant staphylococci.Indlela ye-antibacterial iwukuvimbela ukwakheka kodonga lwamaseli e-bacterial futhi kulimaze ulwelwesi lwe-bacterial cell plasma.Ingakhuthaza ukukhula kwama-microorganisms azuzisayo emathunjini, ikhulise ukungena kwe-mucosa yamathumbu, futhi ikhuthaze ukumuncwa kwezakhi.Ngokuyinhloko isetshenziselwa ukukhuthaza ukukhula kwemfuyo nezinkukhu, ukuvimbela nokulawula isifo sohudo esibangelwa amagciwane emfuyo kanye nezinkukhu kanye nesifo sohudo lwegazi olubangelwa i-Treponema.I-Bacitracin i-zinc ayifuni ukungena ngaphakathi, futhi iningi layo likhishwa ngendle phakathi kwezinsuku ezingu-2, ngakho akulula ukuhlala emfuyweni nasezinkukhu;amagciwane awavamile ukumelana ne-bacitracin, futhi awakwazi ukumelana namanye ama-antibiotics, Futhi anomphumela we-synergistic ne-penicillin, streptomycin, neomycin, aureomycin, polymyxin, njll. Lo mkhiqizo unobuthi obuphezulu futhi awukwazi ukujovwa.Lo mkhiqizo uphikisana ne-olaquindox, i-kitasamycin, i-virginiamycin, ne-Enramycin.
Njengesengezo sokudla, sisetshenziselwa ikakhulukazi ukukhuthaza ukukhula kwemfuyo nezinkukhu, ukuvimbela uhudo olubangelwa amagciwane emfuyo kanye nezinkukhu kanye nesifo sohudo lwegazi olubangelwa i-treponema.I-Bacitracin i-zinc ayifuni ukungena ngaphakathi, futhi iningi layo likhishwa ngendle phakathi kwezinsuku ezingu-2, ngakho akulula ukuhlala emfuyweni nasezinkukhu;amagciwane awavamile ukumelana ne-bacitracin, futhi awakwazi ukumelana namanye ama-antibiotics, Futhi anomphumela we-synergistic ne-penicillin, streptomycin, neomycin, aureomycin, polymyxin, njll. Lo mkhiqizo unobuthi obuphezulu futhi awukwazi ukujovwa.Lo mkhiqizo uphikisana ne-olaquindox, i-kitasamycin, i-virginiamycin, ne-Enramycin.
I-Bacitracin Zinc iyi-antibiotic ye-polypeptide, enomphumela we-bactericidal kubhaktheriya e-gram-positive.Indlela yayo ngokuyinhloko iwukuvimbela ukwakheka kodonga lwebhaktheriya, futhi ingahlanganisa nolwelwesi lwamangqamuzana amagciwane azwelayo, kulimaze ubuqotho be-membrane yeseli, futhi ibangele Ukuphuma kwezinto ezibalulekile esitokisini.Ukuvimbela ngempumelelo amagciwane e-Gram-positive namanye amagciwane e-Gram-negative;izinga lokumelana kwamagciwane ku-bacitracin zinc lihamba kancane, futhi akukho ukumelana namanye ama-antibiotic.Ama-antibiotic e-polypeptide avimbela i-dephosphorylation ye-lipid pyrophosphate, ngaleyo ndlela avimbele ukuhlanganiswa kwezindonga zamangqamuzana amagciwane.
