I-Betamethasone CAS 378-44-9 Purity 97.0%~103.0% Isithombe Esifakiwe Sefekthri ye-API UPurity Okuphezulu

I-Betamethasone CAS 378-44-9 Purity 97.0%~103.0% API Factory High Purity

Incazelo emfushane:

Igama Lekhemikhali: Betamethasone

CAS: 378-44-9

Ukubukeka: I-Crystalline Powder Emhlophe noma Cishe Emhlophe

Ubumsulwa: 97.0%~103.0% we-C22H29FO5, ngokomisiwe

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

378-44-9 - Incazelo:

I-Betamethasone Yezohwebo Enokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Betamethasone
CAS: 378-44-9

378-44-9 -Chemical Properties:

Igama Lekhemikhali	I-Betamethasone
Omqondofana	Isisekelo se-Betamethasone;I-9alpha-Fluoro-16beta-Methylprednisolone;9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione;(11beta,16alpha)-9-Fluoro-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
Inombolo ye-CAS	378-44-9
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C22H29FO5
Isisindo samangqamuzana	392.47
I-Melting Point	235.0~237.0℃
Isimo Sokuthumela	Ngaphansi Kwezinga Lokushisa Le-Ambient
I-COA ne-MSDS	Iyatholakala
Ibhrendi	I-Ruifu Chemical

378-44-9 -Imininingwane:

Into	Imininingwane
Ukubukeka	I-Crystalline Powder Emhlophe noma Cishe Emhlophe
Ukuhlonza A	Ukumuncwa kwe-infrared
Ukuhlonza B	Ukuhlolwa Kokuhlonza Kwe-Chromatographic Yengqimba Encane
I-Specific Optical Rotation	+118.0° ukuya +126.0° (Ibalwa Ngesisekelo Esomisiwe)
Ukungcola Ngamunye	≤1.00%
Ukungcola Okuphelele	≤2.00%
I-Residual Solvents Methanol	≤3000ppm
I-Residual Solvents Chloroform	≤60ppm
Ukulahlekelwa Ekumisweni	≤0.50% (Yomise ku-105℃, amahora angu-3)
Izinsalela ekushiseni	≤0.20%
Ukuhlanzeka / Indlela Yokuhlaziya	97.0%~103.0% we-C22H29FO5 Kubalwe Ngesisekelo Esomisiwe
Izinga Lokuhlola	I-Chinese Pharmacopoeia (CP);I-EP10.0 kanye ne-USP 42
Ukupakisha kanye Nesitoreji	Londoloza ezitsheni eziqinile.Gcina phakathi kuka-2℃ no-30℃.
Isicelo	I-Active Pharmaceutical Ingredient (API)

Iphakheji nesitoreji:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~30℃) nengena umoya omuhle kude nezinto ezingahambelani.Hlala kude nokukhanya okunamandla nokushisa, umswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Izinzuzo:

I-FAQ:

378-44-9 - Ubungozi Nokuphepha:

Amakhodi Engozi R40 - Ubufakazi obulinganiselwe bomphumela we-carcinogenic
R48/20/21 -
I-R61 - Ingabangela ukulimala enganeni engakazalwa
Incazelo Yezokuphepha S22 - Ungaluphefumuli uthuli.
I-S36 - Gqoka izingubo ezifanele zokuzivikela.
S45 - Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
I-S53 - Gwema ukuchayeka - thola imiyalelo ekhethekile ngaphambi kokusetshenziswa.
I-WGK Germany 2
I-RTECS TU4000000
I-HS Code 2937229000
Ubuthi LD50 oral egundwaneni: > 4500mg/kg

378-44-9 -Isicelo:

I-Betamethasone (i-CAS: 378-44-9), ingeye-adrenal corticosteroids, iyi-isomer ye-dexamethasone, futhi indima ye-betamethasone ifana ne-prednisolone ne-dexamethasone, ine-anti-inflammatory, anti-rheumatic, anti-allergic kanye nokucindezela. we-immune kanye neminye imiphumela ye-pharmacological, umphumela wayo wokulwa nokuvuvukala unamandla kune-dexamethasone, i-triamcinolone, i-hydrocortisone njll., inganciphisa futhi ivimbele ukuphendula kwezicubu ekuvuvukeni futhi iqede ukushisa, ubomvu nokuvuvukala okubangelwa ukuvuvukala kwendawo okungatheleleki, ngaleyo ndlela kunciphise ukusebenza kokuvuvukala, umphumela wokulwa nokuvuvukala kwalo mkhiqizo 0.3mg ulingana ne-dexamethasone 0.75mg, prednisone 5mg noma 25mg cortisone.I-Betamethasone sodium retention effect iphindwe kayikhulu kune-hydrocortisone, ku-primary adrenal hypofunction, ingasetshenziswa kanye ne-glucocorticoid ukuze kube nokwelashwa okushintshwayo, futhi isetshenziselwa ukuvimbela noma ukuvimbela ukusabela kwamasosha omzimba, ukubambezeleka kokungezwani komzimba nokunciphisa amasosha omzimba. ukunwetshwa kwempendulo, isetshenziselwa i-renin ephansi kanye ne-aldosterone syndrome ephansi kanye ne-autonomic neuropathy eyenziwe nge-orthostatic hypotension.Njengamanje i-betamethasone isetshenziselwa ukwelapha i-rheumatoid arthritis, i-rheumatoid arthritis, i-lupus, isifuba somoya esinamandla, i-dermatitis enzima, i-acute leukemia, i-atopic dermatitis, i-eczema, i-neurodermatitis, i-seborrheic dermatitis, ne-pruritus kanye nokwelashwa okuphelele kwezifo ezithile.Umkhiqizo uphikisana nomlando onzima wengqondo, isilonda se-duodenal esisebenzayo, i-anastomosis yakamuva ye-gastrointestinal, i-osteoporosis esindayo, isifo sikashukela, umfutho wegazi ophakeme, igciwane , izifo ezibangelwa amagciwane, isikhunta ezihluleka ukulawula ngokusetshenziswa kwama-antimicrobial agents , i-thrombophlebitis, izifo zesikhumba, ezifana njenge-impetigo, i-tinea, i-jock itch nokunye.

378-44-9 - USP35 Okujwayelekile:

I-Betamethasone
C22 H29FO5 392.46
I-Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11,16)-.
I-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione [378-44-9].
I-Betamethasone iqukethe amaphesenti angekho ngaphansi kuka-97.0 futhi angabi ngaphezu kwamaphesenti angu-103.0 we-C22H29FO5, abalwe ngokomisiwe.
Ukupakisha nokugcina-Londoloza ezitsheni eziqinile.Gcina phakathi kuka-2℃ no-30℃.
Amazinga ereferensi we-USP <11>-
I-USP Betamethasone RS
Ukuhlonza-
A: I-Infrared Absorption <197M>.
B: Ukuhlolwa Kokuhlonza Kwe-Chromatographic Thin-Layer <201>-
Isixazululo sokuhlola-Lungiselela isixazululo se-Betamethasone otshwaleni obuphelelwe amanzi emzimbeni obuqukethe u-0.5 mg ngemL ngayinye.
Ukuthuthukisa uhlelo lokuncibilikisa: ingxube ye-chloroform ne-diethylamine (2:1).
Inqubo-Qhubeka njengoba kuqondiswe esahlukweni, ngaphandle kokuthola izindawo ngokufafaza kancane nge-dilute sulfuric acid (1 ku-2) bese ufudumeza ku-hot plate noma ngaphansi kwesibani kuze kuvele amachashaza.
Ukuzungezisa okuqondile <781S>: phakathi kuka-+118 kanye no-+126, kubalwe ngokomisiwe.
Isixazululo sokuhlola: 5 mg nge-mL, ku-methanol.
Ukulahlekelwa ekomisweni 731-Yomise ku-105 amahora angu-3: ayilahlekelwa ngaphezu kuka-1.0% wesisindo sayo.
Izinsalela ekuthungeleni okungu-281: hhayi ngaphezu kuka-0.2%, i-crucible yeplatinamu isetshenziswa.
Ukungcola okuvamile 466-
Isixazululo sokuhlola: i-methanol.
Isixazululo esijwayelekile: i-methanol.
Ivolumu yohlelo lokusebenza: 10 µL.
I-Eluant: ingxube ye-toluene, i-acetone, i-methyl ethyl ketone, ne-formic acid (55:20:20:5), ekamelweni elingalinganiselwe.
Ukubona ngeso lengqondo: 5.
Isivivinyo-
Isigaba seselula-Lungiselela ingxube ehlungiwe nekhishiwe amanzi ne-acetonitrile (63:37).Yenza izinguquko uma kudingeka (bona Ukufaneleka Kwesistimu ngaphansi kwe-Chromatography 621).
Isixazululo sangaphakathi esijwayelekile-Lungisa isixazululo se-propylparaben otshwaleni esinokugxiliswa okwaziwayo okungaba ngu-0.25 mg ngemL ngayinye.
Ukulungiselela okujwayelekile-Chaza isamba esikalwe ngokunembile se-USP Betamethasone RS otshwaleni ukuze uthole isixazululo esinokugxila okwaziwayo okungaba ngu-0.2 mg ngemL ngayinye.Dlulisa u-10.0 mL walesi sixazululo ebhodleleni elifanele, bese wengeza u-10.0 mL wesisombululo esijwayelekile sangaphakathi, ukuze uthole ukulungiswa Okujwayelekile okunokugxila okwaziwayo okungaba ngu-0.1 mg we-betamethasone kanye no-0.125 mg we-propylparaben ngemL.
Ukulungiselela i-Assay-Usebenzisa cishe u-80 mg weBetamethasone, ukalwe ngokunembile, lungiselela njengoba kuqondiswe ekulungiseleleni Okujwayelekile.
Isistimu ye-Chromatographic (bona i-Chromatography 621)-I-chromatograph ewuketshezi ifakwe umtshina ongu-240-nm kanye nekholomu engu-4.6-mm × 25-cm equkethe ukupakisha okungu-L1.Izinga lokugeleza licishe libe ngu-1.0 mL ngomzuzu.I-Chromatograph ukulungiselelwa Okujwayelekile, futhi urekhode izimpendulo eziphakeme njengoba kuqondiswe kuNqubo: izikhathi zokugcinwa okuhlobene zicishe zibe ngu-1.0 we-betamethasone kanye no-1.4 we-propylparaben;ukulungiswa, R, phakathi kwe-betamethasone ne-propylparaben akukhona ngaphansi kuka-3.0;futhi ukuchezuka okujwayelekile okuhlobene kwemijovo eyimpinda akukho ngaphezu kuka-2.0%.
Inqubo-Ngokuhlukile jova amavolumu alinganayo (cishe u-10 µL) wokulungiswa Okujwayelekile kanye nokulungiswa kwe-Assay ku-chromatograph, rekhoda ama-chromatogram, futhi ulinganise izimpendulo zeziqongo ezinkulu.Bala inani, ngo-mg, le-C22H29FO5 engxenyeni ye-Betamethasone ethathwe ifomula:
800C(RU / RS)
lapho u-C eyingqikithi, ngo-mg ngemL ngayinye, ye-USP Betamethasone RS ekulungiseleleni Okujwayelekile;kanye ne-RU ne-RS izilinganiso zobude obuphakeme benani eliphakeme le-betamethasone kanye nenani eliphakeme elijwayelekile langaphakathi elitholwe ekulungiselelweni kwe-Assay nasekulungiseleleni Okujwayelekile, ngokulandelanayo.