I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8 Purity ≥99.5% (HPLC) I-Sitagliptin Phosphate Monohydrate Isithombe Esimaphakathi Esifakiwe

I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8 Purity ≥99.5% (HPLC) Sitagliptin Phosphate Monohydrate Intermediate

Incazelo emfushane:

I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid

I-CAS: 486460-00-8

Ubumsulwa: ≥99.5% (HPLC)

Ukubukeka: Impushana Emhlophe ukuya Emhlophe

I-Sitagliptin Phosphate Monohydrate emaphakathi (CAS: 654671-77-9) yokwelashwa kwesifo sikashukela sohlobo II

Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Thola Izimo Ezihlobene Ne-Sitagliptin Phosphate Monohydrate:
I-Sitagliptin API CAS 486460-32-6
I-Sitagliptin Phosphate Monohydrate API CAS 654671-77-9
2,4,5-Trifluorophenylacetic Acid CAS 209995-38-0
I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid CAS 486460-00-8
I-Sitagliptin Triazole Hydrochloride CAS 762240-92-6
I-Sitagliptin Phosphate Monohydrate Intermediate CAS 486460-21-3

Chemical Properties:

Igama Lekhemikhali	I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid
Omqondofana	(R)-Sitagliptin N-Boc-Acid Ukungcola
Inombolo ye-CAS	486460-00-8
Inombolo yeCAT	I-RF-PI1192
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C15H18F3NO4
Isisindo samangqamuzana	333.31
I-Melting Point	136.0 ~ 138.0℃
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe Kuya Kumhlophe
Ukuhlonza nge-HPLC	Isikhathi Sokugcina Sesampula Sihambisana Nezithenjwa Ezijwayelekile
Ukulahlekelwa Ekumisweni	≤0.50%
Umlotha one-sulphate	≤0.50%
Izinsimbi Ezisindayo	<20ppm
Isomer	≤0.50%
Izinto Ezihlobene
Ukungcola A	≤0.50%
Noma Ikuphi Okunye Ukungcola Okukodwa	≤0.50%
Ukungcola Okuphelele	≤0.50%
Ubumsulwa	≥99.5% (HPLC)
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	Okumaphakathi kwe-Sitagliptin Phosphate Monohydrate (CAS: 654671-77-9)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.

Izinzuzo:

I-FAQ:

Isicelo:

I-Boc-(R)-3-Amino-4-(2,4,5-Trifluoro-Phenyl)-Butyric Acid (CAS: 486460-00-8) iyisimaphakathi esibalulekile sokulungiswa kwe-sitagliptin.I-Sitagliptinphosphate inhibitor yokuqala ye-dipeptidase -IV(DPP-4) egunyazwe yi-FDA ngo-2006. Isetshenziselwa ukwelapha uhlobo lwesifo sikashukela sohlobo lwesibili.Inomphumela osobala we-hypoglycemic lapho isetshenziswa iyodwa noma ihlanganiswe ne-metformin ne-pioglitazone, futhi iphephile ukuyithatha, ibekezelelwa kahle, nokusabela okumbalwa okungekuhle.Ngo-Agasti 2009, umuthi wagunyazwa yi-European Union njengomuthi womugqa wokuqala wokwelapha isifo sikashukela sohlobo 2.Ngemuva kuka-2011, amazwe ngemva kwamanye agunyaze inhlanganisela ye-sitagliptin phosphate ne-alpha glycosidase inhibitors noma i-insulin.I-Sitagliptin phosphate iyi-inhibitor yokuqala ye-dipeptidyl peptidase-IV egunyazwe yi-FDA ukuthi isetshenziselwe ukwelapha uhlobo 2 sikashukela kuze kube manje, ngaphansi kwegama lokuhweba elithi Januvia.