I-Brexpiprazole CAS 913611-97-9 Purity >99.0% (HPLC) API Factory
I-Ruifu Chemical Supply Brexpiprazole Intermediates
I-Brexpiprazole CAS 913611-97-9
I-7-Hydroxyquinolinone CAS 70500-72-0
4-Bromobenzo[b]thiophene CAS 5118-13-8
1-(1-Benzothiophen-4-yl)piperazine Hydrochloride CAS 913614-18-3
7-(4-Chlorobutoxy)quinolin-2(1H)-one CAS 913613-82-8
4-Chlorobenzo[b]thiophene CAS 66490-33-3
Igama Lekhemikhali | I-Brexpiprazole |
Omqondofana | I-OPC-34712;7-(4-(4-(Benzo[b]thiophen-4-yl)piperazin-1-yl)butoxy)quinolin-2(1H)-one |
Inombolo ye-CAS | 913611-97-9 |
Inombolo yeCAT | I-RF-PI1982 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C25H27N3O2S |
Isisindo samangqamuzana | 433.57 |
Ukuminyana | 1.245±0.060 g/cm3 |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Crystalline Powder Emhlophe noma Engamhlophe |
Ukuhlonza | Ibhalwe ngu-IR |
RT | Ngaphansi kwe-chirality kufanele ihambisane |
I-Chloride | Inikeza ukusabela kwe-chloride |
Amanzi | 3.0%~4.5% |
I-Melting Point | 198.0~202.0℃ |
Izinsalela ekushiseni | <0.20% |
Izinsimbi Ezisindayo | ≤10ppm |
Izinto Ezihlobene | |
Ukungcola Ngamunye | <0.50% |
Ukungcola Okuphelele | <1.00% |
EE | >99.0% |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC, ngokomile) |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-API |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
I-Brexpiprazole (CAS: 913611-97-9) iyikhandidethi lezidakamizwa eliwusizo ekwelapheni nasekuvimbeleni ukuphazamiseka kwengqondo okuhlanganisa ukuphazamiseka kwe-CNS.I-Brexpiprazole iyinoveli yesidakamizwa se-antipsychotic esebenza njengemoduli yomsebenzi we-serotonin ® dopamine futhi ibonise ukusebenza kahle njengokwelashwa okungeziwe ezigulini ezinokuphazamiseka okukhulu kokucindezeleka (MDD).I-Brexpiprazole ibonisa iphrofayili ye-pharmacological eyingqayizivele, esebenza njenge-agonist ingxenye ye-serotonin 5-HT1A kanye ne-dopamine D2 receptors futhi njengomphikisi ogcwele we-5-HT2A kanye ne-noradrenaline α1B / 2C receptors, enobudlelwane obubophezelayo obufanayo be-subnanomolar.I-Brexpiprazole yathuthukiswa ngabakwa-Otsuka kanye no-Lundbeck, yagunyazwa ngo-2015 yi-FDA yokwelapha i-schizophrenia kanye nokwelapha okuhlanganisa nokudangala.I-Brexpiprazole ibhekwa kabanzi njengelandela isidakamizwa se-antipsychotic sika-Otsuka i-aripiprazole (igama lokuhweba i-Abilify) ilungelo layo lobunikazi eliphelelwe yisikhathi ngo-Agasti 2014.