I-Brimonidine Tartrate CAS 70359-46-5 Assay 99.0%~101.0%
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Brimonidine Tartrate (CAS: 70359-46-5) enekhwalithi ephezulu.I-α2-adrenergic receptor agonist ekhethiwe, umuthi osetshenziselwa ukwelapha i-glaucoma evulekile noma i-ocular hypertension.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Brimonidine Tartrate,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Brimonidine Tartrate |
| Omqondofana | I-Brimonidine L-Tartrate;I-UK 14304 Tartrate;I-AGN190342 I-Tartrate;I-5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)quinoxalin-6-Amine Tartrate;I-5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)-6-Quinoxalinamine Tartrate;5-Bromo-N-(4,5-Dihydro-1H-Imidazol-2-yl)quinoxalin-6-Amine (2R,3R) -2,3-Dihydroxysuccinate |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 70359-46-5 |
| I-Molecular Formula | C11H10BrN5·C4H6O6 |
| Isisindo samangqamuzana | 442.23 g/mol |
| I-Melting Point | 207.0~208.0℃(dec.) |
| Kuyazwela | Izwela Umoya, Izwela Ukushisa |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| I-Shelf Life | Izinyanga Ezingu-24 Uma Zigcinwe Ngokufanelekile |
| Isigaba | I-API (Isithako Semithi Esisebenzayo) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Okumhlophe noma Okuphuzi Kancane noma I-Brownish Powder Kancane | Kuyavumelana |
| Ukuhlonza A | I-Specific Optical Rotation | Kuyavumelana |
| Ukuhlonza B | I-Infrared Absorption Spectrophotometry | Kuyavumelana |
| Ukuncibilika | Incibilika emanzini, cishe ayincibiliki ku-ethanol eyi-anhydrous kanye ne-toluene | Kuyavumelana |
| I-Specific Optical Rotation | +9.0° ~ +10.5° | +9.6° |
| Ukulahlekelwa Ekumisweni | ≤0.50% | 0.20% |
| I-Sulfated Ash | ≤0.20% | 0.07% |
| Izinsimbi Ezisindayo | ≤20ppm | <20ppm |
| Izinto Ezihlobene | ||
| Ukungcola Okucacisiwe | ||
| I-N-(imidazolidin2ylidene)quinoxalin-6-amine | ≤0.10% | Kuyavumelana |
| 5-bromoqulinoxalin-6-amine | ≤0.10% | Kuyavumelana |
| I-Quinoxalin-6-amine | ≤0.10% | Kuyavumelana |
| 1-(5-bromoquinoxalin-6-yl) thiourea | ≤0.10% | Kuyavumelana |
| 2-(5-bromoquinoxalin-6-yl)guanidine | ≤0.10% | Kuyavumelana |
| 5-bromo-N-(1H-imidazol-2-yl)Quinoxalin-6-amine | ≤0.10% | Kuyavumelana |
| 1-(2-aminoethyl)-3-(5-bromoquinoxalin-6-yl) urea | ≤0.10% | Kuyavumelana |
| Ukungcola Okungashiwongo | ≤0.10% | Kuyavumelana |
| Isamba | ≤0.20% | 0.12% |
| Isivivinyo | 99.0%~101.0%(Kusisekelo Esomisiwe) | 99.8% |
| Isiphetho | Lo mkhiqizo ngokuhlola uvumelana ne-BP2015 Standard | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Gwema ukuchayeka elangeni eliqondile, umswakama kanye nokushisa ngokweqile.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
Izitatimende Zengozi H301: Inobuthi uma igwinywe.
Izitatimende Zokuqapha
I-P501: Lahla okuqukethwe/isiqukathi endaweni egunyaziwe yokulahla udoti.
I-P270: Ungadli, ungaphuzi noma ubheme lapho usebenzisa lo mkhiqizo.
I-P264: Geza isikhumba kahle ngemva kokuphatha.
I-P301 + P310 + P330: UMA IGWANYWA: Shayela ngokushesha I-POISON CENTRE/udokotela.Hlanza umlomo.
P405: Isitolo sivaliwe.
Imithetho Ehlobene:
Ulwazi lwezokuthutha:
Inombolo ye-UN (DOT-AIR) UN2811
Ikilasi (DOT-AIR) 6.1
Iqembu Lokupakisha (TCI-A) III
Inombolo ye-HS 2933.29.9000
I-Brimonidine Tartrate (i-CAS: 70359-46-5) iyi-blocker ekhethiwe kakhulu ye-α2-receptor, eyakhiwe ngempumelelo yi-US Company Allergan, okuyimithi yamehlo.Inganciphisa umfutho we-intraocular (IOP).I-Brimonidine Tartrate ophthalmic solution ethengiswayo emakethe ifomu le-Brimonidine Tartrate, okuwumuthi omuhle owehlisa i-IOP we-glaucoma evulekile evulekile engapheli kanye nokwelashwa komfutho wegazi ophakeme we-ocular weziguli, kodwa futhi namazinga e-argon laser IOP.Isixazululo se-Brimonidine Tartrate ophthalmic sinezindlela ezimbili zokusebenza ngokunciphisa ukukhiqizwa kwamahlaya ane-aqueous kanye nokwandisa ungqimba lwe-pigment lwezinjongo zokwelapha zokuphuma kwe-liquid scleral.Ngemuva kokuwela esweni, umphumela uyashesha, futhi ungafinyelela phezulu uma usebenzisa kufika ku-2h, futhi isikhathi esisebenzayo singagcina i-12h.Igazi lingathola iminonjana yezidakamizwa kuphela.Lo mkhiqizo une-metabolism ye-first pass metabolism esibindini, futhi ama-metabolites akhishwa umchamo yizinso.Ukumuncwa okuhlelekile nokusabalalisa akuthinteki, futhi abantu abadala abadingi ukulungiswa komthamo.Isixazululo se-Brimonidine Tartrate ophthalmic uma siqhathaniswa namanye ama-α-blockers, i-fat-soluble incane, kuyilapho akulula ukudlula umgoqo wegazi-ubuchopho futhi ayikhiqizi i-sedation, i-hypotension kanye nokunye okufanayo okungahambisani ne-clonidine central.Isixazululo se-Brimonidine Tartrate Ophthalmic Solution sikhetha kakhulu ama-α2-adrenergic receptors, futhi isilinganiso se-α2/α1 se-receptor affinity singaphezu kwezikhathi eziyi-1000.Umphumela we-alpha 2 receptors ungaholela ekucindezelekeni okuphansi kwe-intraocular.Futhi indima ye-alpha 1 receptors ingaholela ekufinyezweni kwemithambo, ukuhlehla kwejwabu leso noma ukunciphisa kanye nokwenyuka komfundi.Ukusetshenziswa kwesikhathi eside kwalo mkhiqizo ngeke kubangele ukungezwani komzimba ngokushesha.Ngaphezu kwalokho, uma kuqhathaniswa nama-β-blockers, i-Brimonidine Tartrate iso yethonsi yemiphumela emincane yenhliziyo nemithambo yegazi, ayinawo umthelela ekusebenzeni kwamaphaphu, ngakho ifanele iziguli ezikhubazekile ezingama-β-blockers.Ngaphezu kwalokho, uma isetshenziswa iyodwa i-β-blocker, ayikwazi ukufeza izinjongo zokwelapha, futhi unganyusa ngasikhathi sinye i-FDA.
