I-Candesartan Cilexetil CAS 145040-37-5 Ukuhlanzeka >99.0% (HPLC) Isithombe Esifakiwe Sefekthri ye-API

Candesartan Cilexetil CAS 145040-37-5 Purity >99.0% (HPLC) API Factory

Incazelo emfushane:

Igama Lekhemikhali: Candesartan Cilexetil

I-CAS: 145040-37-5

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: I-Crystalline Powder Emhlophe ukuya Kokumhlophe

I-Angiotensin II Receptor Antagonist ekhethiwe

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Candesartan Cilexetil Intermediate With High Purity
I-Candesartan Cilexetil CAS 145040-37-5
I-Candesartan CAS 139481-59-7
I-1-Chloroethyl Cyclohexyl Carbonate CAS 99464-83-2
Candesartan Cilexetil Intermediate Eethyl Ester C6 CAS 139481-41-7
I-Candesartan Cilexetil I-CAS 139481-44-0
I-Trityl Candesartan Cilexetil CAS 170791-09-0

Chemical Properties:

Igama Lekhemikhali	I-Candesartan Cilexetil
Omqondofana	I-TCV-116;1-(((Cyclohexyloxy)carbonyl)oxy)ethyl 1-((2'-(1H-tetrazol-5-yl)-[1,1'-biphenyl]-4-yl)methyl)-2-ethoxy-1H -benzo[d]imidazole-7-Carboxylate
Inombolo ye-CAS	145040-37-5
Inombolo yeCAT	I-RF-PI1891
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C33H34N6O6
Isisindo samangqamuzana	610.66
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	I-Crystalline Powder emhlophe ukuya kokumhlophe
Ukuhlonza HPLC	Isikhathi sokugcinwa sesiqongo esikhulu ku-chromatogram yesampula sihambisana naleso esiku-chromatogram etholwe nezinga
Ukuhlonza IR	I-IR infrared absorption spectrum iyafana naleyo yeCandesartan Cilexetil inkomba ejwayelekile
Ukucaca kanye nesixazululo sombala	Isixazululo ku-chloroform ku-5% sicacile futhi asinambala
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
I-Melting Point	155.0 ~ 160.0℃
Ukulahlekelwa Ekumisweni	<0.30%
Izinsalela ekushiseni	<0.10%
Izinsimbi Ezisindayo	<10ppm
I-Arsenic (As)	<1ppm
Ukusabalalisa Usayizi Wezinhlayiyana	90% <30 μm
Ukungcola Okuphilayo	nge-HPLC
Ethyl Candesartan	<0.15%
I-Desethyl Candesartan	<0.15%
N2-Ethyl Candesartan Cilexei	<0.15%
Noma yikuphi Ukungcola Okungaziwa	<0.15%
Ukungcola Okuphelele	<0.60%
Ukuhlolwa kwe-Potentiometry	99.0~101.0% ye-C33H34N6O6, ibalwe entweni engenamanzi
I-Organic Volatile Ukungcola
I-Methano	<0.30%
I-Ethanol	<0.50%
I-Diethyl Ether	<0.50%
I-aceton	<0.50%
I-Dichloromethan	<0.06%
I-Dimethylformamide	<0.088%
I-Microbiological Contarnination
Isamba se-Aerobic Microbial Count	<1000cfu/g
Isikhunta & Imvubelo	<100cfu/g
E.Coli	Akekho
I-Salmonella	Akekho
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-API;I-ejenti ye-Antihypertensive

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-Candesartan Cilexetil (TCV-116) (i-CAS: 145040-37-5) i-angiotensin II receptor antagonist ene-IC50 ye-0.26 nM, esetshenziselwa ukwelapha umfutho wegazi ophezulu.I-Candesartan iyi-angiotensin-receptor blocker (ARB) engasetshenziswa yodwa noma namanye ama-ejenti ukwelapha umfutho wegazi ophakeme.Iphathwa ngomlomo njenge-prodrug, i-candesartan cilexetil, eguqulwa ngokushesha ibe yi-metabolite yayo esebenzayo, i-candesartan, ngesikhathi sokumuncwa emgudwini wesisu.I-Candesartan yehlisa umfutho wegazi ngokuphikisana nohlelo lwe-renin-angiotensin-aldosterone (RAAS);iqhudelana ne-angiotensin II ngokubopha uhlobo-1 lwe-angiotensin II receptor (AT1) futhi ivimbele imiphumela ekhuphukayo yomfutho wegazi we-angiotensin II.Ngokungafani nama-angiotensin-converting enzyme (ACE) inhibitors, ama-ARB awanawo umthelela omubi wokukhwehlela okomile.I-Candesartan ingasetshenziselwa ukwelapha umfutho wegazi ophakeme, umfutho wegazi ophakeme we-systolic, i-left ventricular hypertrophy kanye ne-nephropathy yesifo sikashukela.Ingase futhi isetshenziswe njengenye indlela yokwelapha ukuhluleka kwenhliziyo, ukungasebenzi kahle kwe-systolic, i-myocardial infarction kanye nesifo se-coronary artery.