I-Carvedilol CAS 72956-09-03 Ukuhlanzeka >99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili weCarvedilol (CAS: 72956-09-03) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga iCarvedilol,Please contact: alvin@ruifuchem.com
Abaphakathi Abahlobene beCarvedilol
Igama Lekhemikhali | I-Carvedilol |
Omqondofana | 1-(9H-Carbazol-4-yloxy)-3-[[2-(2-Methoxyphenoxy)ethyl]amino]-2-Propanol;Iciko;Cadilan;I-Carca;I-Cardivas;UCarloc;I-Carvas;I-Carvedilol;I-Carvediol;I-Coreg;I-DQ 2466;I-Dilatrend;I-Dimitone;I-Eucardic;I-Korvasan;I-Kredex;Querto;Talliton;BM-14190 |
Isimo Sesitoko | Esitokweni, i-GMP Commercial |
Inombolo ye-CAS | 72956-09-3 |
I-Molecular Formula | I-C24H26N2O4 |
Isisindo samangqamuzana | 406.48 g/mol |
I-Melting Point | 115.0 ukuze 119.0 ℃ |
Ukuminyana | 1.250±0.06 g/cm3 |
Ukuncibilika Emanzini | Ayincibiliki Emanzini |
Ukuncibilika | I-Soluble ku-Methanol.Incibilika Kancane ku-Ethanol, Ether |
Isikhathi Sokugcina. | Indawo epholile neyomile (2~8℃) |
I-COA ne-MSDS | Iyatholakala |
Ibhrendi | I-Ruifu Chemical |
Izinto | Amazinga Wokuhlola | Imiphumela |
Ukubukeka | I-Crystalline Powder Emhlophe | Iyahambisana |
Ukulahlekelwa Ekumisweni | ≤0.50% (105℃ amahora angu-3) | 0.25% |
Izinsalela ekushiseni | ≤0.10% | 0.07% |
Izinto Ezihlobene | ||
Ukungcola Okuphelele | ≤0.50% | Iyahambisana |
Ukungcola A | ≤0.20% | Iyahambisana |
Ukungcola C | ≤0.02% | Iyahambisana |
Noma Ikuphi Okunye Ukungcola Komuntu Ngamunye | ≤0.10% | Iyahambisana |
Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) | 99.72% |
I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nezicaciso |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina esitsheni esivalwe ngci.Gcina endaweni epholile, eyomile (2~8℃) futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
Amakhodi Wengozi N,Xn
Izitatimende zobungozi 51/53-36/37/38-20/21/22
Izitatimende Zokuphepha 61-36-26
I-RIDADR UN 3077 9/PG 3
I-WGK Germany 3
I-RTECS UA8670000
I-HazardClass IRRITANT
UkupakishaIqembu III
Idatha Yezinto Eziyingozi 72956-09-3(Idatha Yezinto Eziyingozi)
Ubuthi be-LD50 ngomlomo enjeni: > 1gm/kg
I-Carvedilol (i-CAS: 72956-09-03) i-vasodilating beta-blocker ewusizo ekwelapheni umfutho wegazi ophezulu kanye ne-angina pectoris.Ngaphezu kokwehlisa umfutho wegazi, i-carvedilol inciphisa ukumelana nemithambo ngaphandle kwe-reflex tachycardia evame ukwenzeka ngama-vasodilator.Kubikwa ukuthi ibekezelelwa kahle ngemiphumela yokonga ezinso.
I-Carvedilol yethulwa okokuqala e-Belgium ngo-1985. Lo mkhiqizo ungavimba ama-alpha ne-beta receptors, akukho msebenzi wangaphakathi, ekugxilweni okuphezulu kwemfashini nokuphikisana ne-calcium.Inomphumela oqinile wokuvimbela ama-beta receptors, anganweba imithambo yegazi, anciphise ukumelana ne-peripheral kanye nomfutho wegazi ophansi, futhi anomthelela omncane ekuphumeni kwenhliziyo nokushaya kwenhliziyo.I-Clinical ingasetshenziselwa umfutho wegazi ophakeme kanye ne-angina pectoris.
rU= | impendulo ephezulu ye-carvedilol kusuka kusixazululo Sesampula |
rS= | impendulo ephezulu ye-carvedilol kusuka kusixazululo esijwayelekile |
CS= | ukuhlushwa kwe-carvedilol kusixazululo esijwayelekile (mg/mL) |
CU= | ukuhlushwa kweCarvedilol kusixazululo Sesampula (mg/mL) |
rU | = | impendulo ephezulu yenhlanganisela ehambisanayo ehambisanayo noma okunye ukungcola okuvela kusixazululo Sesampuli |
rS | = | impendulo ephezulu yenhlanganisela ehambisanayo ehambisanayo evela kusixazululo Esijwayelekile.Ukuze ubale iphesenti lanoma yikuphi okunye ukungcola komuntu sebenzisa impendulo ephakeme ye-carvedilol. |
CS | = | ukuhlushwa kwenhlanganisela ehambisanayo ehambisanayo kusixazululo Esijwayelekile (mg/mL).Ukuze ubale iphesenti lanoma yikuphi okunye ukungcola kwe-CS, sebenzisa ukugxila kwe-USP Carvedilol RS. |
CU | = | ukuhlushwa kweCarvedilol kusixazululo Sesampula (mg/mL) |
Igama | Isikhathi Sokugcina Esihlobene | Imibandela Yokwamukela, i-NMT (%) | |
I-Carvedilol ehlobene ne-Ea | 0.35 | 0.1 | |
I-Carvedilol ehlobene nenhlanganisela Ab | 0.52 | 0.1 | |
I-Carvedilol bisalkylpyrocatechol derivative (uma ikhona)c | 0.70 | 0.15 | |
I-Carvedilol | 1.0 | - | |
I-Carvedilol ehlobene ne-Cd | 3.6 | 0.02 | |
I-Carvedilol ehlobene ne-compound De | 5.0 | 0.1 | |
I-Carvedilol ehlobene ne-compound Bf | 8.5 | 0.1 | |
Noma yikuphi okunye ukungcola komuntu ngamunye | - | 0.10 | |
Ukungcola okuphelele | - | 0.5g | |
i-2-(2-Methoxyphenoxy) ethyl amine. b 1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2 -ol. c 3,3¢-{2,2¢-[1,2-Phenylenebis(oxy)]bis(ethane-2,1-diyl)}bis(azanediyl)bis(1-(9H-carbazol-4-yloxy) ipropan-2-ol). d 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. e 4-(Oxiran-2-ylmethoxy) -9H-carbazole. f 3,3¢-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g Unganaki noma yikuphi ukungcola okungaphansi kuka-0.01%. |
Isikhathi (imizuzu) | Isixazululo A (%) | Isixazululo B (%) |
---|---|---|
0 | 22 | 78 |
20 | 22 | 78 |
33 | 38 | 62 |
45 | 38 | 62 |
55 | 55 | 45 |
65 | 55 | 45 |
68 | 22 | 78 |
80 | 22 | 78 |
rU | = | impendulo ephezulu yokungcola ngakunye kusixazululo Sesampuli |
rT | = | Isamba sazo zonke izimpendulo eziphezulu kusixazululo Sesampula |
Igama | Isihlobo Ukugcinwa Isikhathi | Ukwamukela Imibandela, I-NMT (%) | |
---|---|---|---|
I-Carvedilol ehlobene nenhlanganisela Aa | 0.7 | 0.1 | |
I-Carvedilol | 1.0 | - | |
I-Carvedilol ehlobene ne-Fb | 1.2 | 0.1c | |
I-N-Isopropylcarvedilold | 1.6 | 0.1 | |
I-Carvedilol ehlobene ne-Ce | 1.8 | 0.02 | |
I-Carvedilol ehlobene ne-compound Bf | 2.1 | 0.1 | |
I-Biscarbazoleg | 3 | 0.1 | |
Noma yikuphi okunye ukungcola komuntu ngamunye | - | 0.1 | |
Ukungcola okuphelele | - | 0.5 | |
i-propoxy engu-1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino))-9Hcarbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2-ol . b 1-(2-(2-Methoxyphenoxy)ethylamino)-3-(6,7,8,9-tetrahydro-5H-carbazol-4-yloxy)propan-2-ol. c Lokhu kungcola kubalwa kusetshenziswa inqubo ngaphansi Kokungcola Kwezinto Eziphilayo, Inqubo 3: I-Carvedilol Related Compound F. d 1-(H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]N-isopropylamino]-2-propanol. e 1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol. f 3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol). g 1,3-Bis-(9H-carbazol-4-yloxy)-2-propanol. |
rU | = | impendulo ephakeme ye-carvedilol ehlobene ne-compound F kusukela kusixazululo seSampula |
rT | = | Isamba sezimpendulo eziphezulu ze-carvedilol kanye ne-carvedilol ehlobene ne-compound F kusukela kusixazululo seSampuli |
F | = | isici sokuphendula esihlobene, 1.1 |
1-(4-(2-Hydroxy-3-(2-(2-methoxyphenoxy)ethylamino)propoxy)-9H-carbazol-9-yl)-3-(2-(2-methoxyphenoxy)ethylamino) propan-2- ol.
C36H43N3O7 629.74
3,3'-(2-(2-Methoxyphenoxy)ethylazanediyl)bis(1-(9H-carbazol-4-yloxy)propan-2-ol).
C39H39N3O6 645.74
1-(9H-Carbazol-4-yloxy)-3-(benzyl(2-(2-methoxyphenoxy)ethyl)amino)propan-2-ol.
I-C31H32N2O4 496.60
4-(Oxiran-2-ylmethoxy) -9H-carbazole.
I-C15H13NO2 239.27
2-(2-Methoxyphenoxy)ethyl amine.
I-C9H13NO2 167.21
Ingxube ecishe ibe ngu-0.1% yenhlanganisela ye-carvedilol F (1-(2-(2-Methoxyphenoxy)ethylamino)-3-(2,3,4,9-tetrahydro-1H-carbazol-5-yloxy)propan-2-ol) ku-matrix yesidakamizwa se-carvedilol.