I-Daclatasvir Dihydrochloride Intermediate CAS 1007882-23-6 Ubumsulwa >98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Daclatasvir Dihydrochloride Intermediate (CAS: 1007882-23-6) enekhwalithi ephezulu.I-Ruifu Chemical ingahlinzeka ngokulethwa komhlaba wonke, amanani ancintisanayo, amanani amancane nayinqwaba atholakalayo.Thenga i-Daclatasvir Dihydrochloride Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) |
| Omqondofana | I-Daclatasvir Intermediate Ⅱ;I-Dacaltasvir Ephakathi 02;I-Daclatasvir T-Butyl Ester;I-Bis(2-Methyl-2-Propanyl) (2S,2'S)-2,2'-[4,4'-Biphenyldiylbis(1H-Imidazole-4,2-diyl)]di(1-Pyrrolidinecarboxylate);I-Di-tert-butyl 2,2′-([1,1′-Biphenyl]-4,4′-diylbis(1H-Imidazole-5,2-diyl))(2S,2'S)-bis(Pyridineidine-1- I-Carboxylate);(2S,2'S)-2,2'-([1,1'-Biphenyl]-4,4'-diyldi-1H-Imidazole-5,2-diyl)bis-1-Pyrrolidinecarboxylic Acid 1,1'-Bis (1,1-Dimethylethyl) Ester;I-Daclatasvir Ukungcola 4 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 1007882-23-6 |
| I-Molecular Formula | I-C40H51ClN8O6 |
| Isisindo samangqamuzana | 775.35 g/mol |
| Iphuzu elibilayo | 890.2±65.0℃ ku-760 mmHg |
| Ukuminyana | 1.220±0.06 g/cm3 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | Okumaphakathi kwe-Daclatasvir Dihydrochloride (CAS: 1009119-65-6) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana Ephuzi Ekhanyayo ukuya Ephuzi | Impushana Ephuzi Ekhanyayo |
| Ukulahlekelwa Ekumisweni | <1.00% | 0.65% |
| Ukungcola Okukodwa Okukhulu | <1.00% | 0.45% |
| Ukungcola Okuphelele | <2.00% | 1.24% |
| Ukuhlanzeka / Indlela Yokuhlaziya | >98.0% (HPLC) | 98.76% |
| I-Infrared Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
| Isicelo | Okumaphakathi kwe-Daclatasvir Dihydrochloride (CAS: 1009119-65-6) | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isitsha sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-Di-tert-Butyl (2S,2'S)-2,2'-(4,4'-Biphenyldiylbis(1H-imidazole-5,2-diyl))di(1-Pyrrolidinecarboxylate) (CAS: 1007882-23-6) iphakathi kwe-Daclatasvir Dihydrochloride (CAS: 1009119-65-6).
I-Daclatasvir (i-Daklinza) ithole isimo "sokubuyekezwa okubalulekile", okuhlanganiswe ne-Sorafenib yokwelapha iziguli ezikhulile ze-genotype III ezine-hepatitis C engapheli. ukutheleleka ngaphandle kokuphatha ngokubambisana ne-interferon noma i-ribavirin.I-Interferon ne-Ribavirin yimithi emibili egunyazwe yi-FDA yokwelapha ukutheleleka ngegciwane le-hepatitis C.I-Hepatitis C yisifo segciwane esingabangela ukuvuvukala kwesibindi, okuholela ekunciphiseni ukusebenza kwesibindi noma ukwehluleka kwesibindi.Iziguli eziningi ezingenwe isifo sokusha kwesibindi kohlobo C azinazo izimpawu kuze kube yilapho kubonakala ukulimala kwesibindi, okungase kuthathe iminyaka eminingana.Emhlabeni jikelele, i-genotype III i-hepatitis C iwuhlobo lwesibili oluvame kakhulu lwesifo sokusha kwesibindi kohlobo C ngemuva kwe-genotype 1 ye-hepatitis C futhi sithathwa njengesinye sezifo ze-genotype eziphika kakhulu.I-Daklinza iyi-pan-genotype NS5A replication complex inhibitor, esebenza ngempumelelo ekuvimbeleni ukuphindaphinda kwe-RNA nokuhlangana kwegciwane, umphumela we-antiviral okabili.Ezifundweni ze-in vitro, i-Daklinza iboniswe ukuthi inomphumela wokulwa negciwane ngokumelene ne-genotype 1 ~ 6 igciwane le-hepatitis C.I-Daklinza ihambisana nesexwayiso sokuthi inhlanganisela ye-amiodarone, i-Daklinza ne-Sofosbuvir ingase ibangele ukushaya kwenhliziyo okunciphe kakhulu.I-Daklinza ithebhulethi yomlomo enomthamo onconyiwe ongu-60 mg izikhathi ezi-1/d, ngokuhlangana ne-Sofosbuvir ingqikithi yamasonto ayi-12.
Inkampani yocwaningo nentuthuko: Bristol-Myers Squibb.
I-Patent Literature: WO 2008021927A2 (August 9, 2007).
Isikhathi sokumaketha: Julayi 24, 2015 esohlwini lwase-United States, igama lokuhweba Daklinza.
Izinkomba: Isetshenziswa lihambisana Sofosbuvir ekwelapheni genotype 3 chronic hepatitis C (HCV) ukutheleleka.
Indlela yokwenza: i-HCV nonstructural protein 5A (NS5A) inhibitors.Ukusabela Okubi: ubuhlungu bekhanda nokukhathala.
Ukwakhiwa kanye nokucaciswa: Amaphilisi, 30 kanye 60mg.
