I-Risperidone CAS 106266-06-2 Assay 98.0~102.0%
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Risperidone (CAS: 106266-06-2) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Risperidone,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Risperidone |
| Omqondofana | 3-[2-[4-(6-Fluoro-1,2-Benzisoxazol-3-yl)-1-Piperidinyl]ethyl]-6,7,8,9-Tetrahydro-2-Methyl-4H-Pyrido[1 ,2-a]pyrimidin-4-one;I-Risperdal;I-Risperidal;Risperdal Consta;I-Rispolept;I-Risperin;I-Rispolin;I-Sequinan;I-Risperdal M-Tab |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 106266-06-2 |
| I-Molecular Formula | I-C23H27FN4O2 |
| Isisindo samangqamuzana | 410.49 g/mol |
| I-Melting Point | 170.0 ukuze 174.0 ℃ |
| Ukuminyana | 1.38±0.10 g/cm3 |
| I-Hazard Class | 6.1;Ubuthi |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana Emhlophe Kuya Kumhlophe | Iyahambisana |
| Ukuhlonza A | Ukumuncwa kwe-infrared | Iyahambisana |
| Ukuhlonza B | Isikhathi Sokugcina: Sihambisana Nereferensi Into | Iyahambisana |
| Ukulahlekelwa Ekumisweni | <0.50% | 0.12% |
| Izinsalela ekushiseni | <0.10% | 0.07% |
| Izinsimbi Ezisindayo | <0.001% | <0.001% |
| Izithako Ezihlobene | ||
| E-Oxime | <0.20% | <0.20% |
| Z-Oxime | <0.20% | <0.20% |
| I-9-Hydroxyrisperidone | <0.20% | <0.20% |
| I-5-Fluororisperidone | <0.20% | <0.20% |
| 6-Methylrisperidone | <0.20% | <0.20% |
| Noma yikuphi Ukungcola Okungaziwa | <0.10% | <0.10% |
| Ukungcola Okuphelele | <0.30% | <0.30% |
| Isivivinyo | 98.0~102.0% (Ibalwe Ngesisekelo Esomile) | 100.52% |
| Isiphetho | Umkhiqizo uhloliwe futhi uhambisana ne-USP 35 Standard | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
I-Risperidone
I-C23H27FN4O2 410.48
4H-Pyrido[1,2-a]pyrimidin-4-one, 3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7 ,8,9-tetrahydro-2-methyl-.
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one [106266-06-2].
» I-Risperidone iqukethe amaphesenti angekho ngaphansi kuka-98.0 futhi angabi ngaphezu kwamaphesenti angu-102.0 we-C23H27FN4O2, abalwe ngokomisiwe.
Ukupakisha nokugcina- Londoloza ezitsheni ezivalwe kahle.Gcina ekamelweni lokushisa.
Amazinga ereferensi we-USP <11>-
USP Risperidone RS
3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]ethyl]-6,7,8,9-tetrahydro-2-methyl-4H-pyrido[1,2- a]pyrimidin-4-one 410.48 CAS-106266-06-2
I-USP Risperidone System Suitability Mixture RS
Iqukethe i-risperidone futhi cishe u-0.2% walokhu okulandelayo:
Z-Oxime-3-[2-[4-[(Z))-(2,4-difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9- i-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
9-Hydroxyrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, I-8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
6-Methylrisperidone-(6RS)-3-[2-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7, I-8,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one.
[Qaphela-Le ngxube iqukethe i-risperidone, i-Z-oxime, i-9-hydroxyrisperidone, ne-6-methylrisperidone.]
Ukuhlonza-
A: I-Infrared Absorption <197K>.
B: Isikhathi sokugcinwa sesiqongo esikhulu ku-chromatogram yokulungiselelwa kwe-Assay sihambisana naleso esiku-chromatogram yokulungiselelwa Okujwayelekile, njengoba kutholwe ku-Assay.
Ukulahlekelwa ekumisweni <731>- Yomisa ku-vacuum ku-80 amahora angu-4: ilahlekelwa ngaphezu kuka-0.5% wesisindo sayo.
Izinsalela ekushiseni <281>: hhayi ngaphezulu kuka-0.1%, kusetshenziswa isifanekiso sokuhlola esingu-2.0-g.
Izinsimbi ezinzima, Indlela II <231>: 0.001%.
Izinhlanganisela ezihlobene-
Isixazululo se-Buffer, Isixazululo A, Isixazululo B, Isigaba Seselula, I-Diluent, Isixazululo sokufaneleka Kwesistimu, kanye nesistimu ye-Chromatographic-Lungiselela njengoba kuqondiswe ku-Assay.
Isixazululo esijwayelekile-Sebenzisa ukulungiselela Okujwayelekile, okulungiselelwe njengoba kuqondiswe ku-Assay.
Isixazululo sokuhlola-Sebenzisa ukulungiswa kwe-Assay.
Inqubo-Jonga amavolumu alinganayo (cishe u-10 µL) wesisombululo Esijwayelekile kanye nesixazululo sokuhlola ku-chromatograph, bese urekhoda i-chromatogram.Khomba ukungcola usebenzisa izikhathi zokugcina ezilinganiselwe ezinikezwe kuThebula 1, futhi ulinganise izimpendulo eziphezulu.Bala iphesenti lenhlanganisela ngayinye ehlobene ne-risperidone engxenyeni ye-Risperidone ethathwe ifomula:
100(CS /CU)(rU / rS)(1/F)
lapho i-CS ne-CU kukhona ukugxilisa, ngo-mg nge-mL ngayinye, ye-risperidone kusixazululo Esijwayelekile kanye nesixazululo sokuhlola ngokulandelana;I-rU iyindawo ephakeme kakhulu yokungcola ngakunye okutholakala kusixazululo sokuhlola;I-rS iyindawo ephakeme kakhulu ye-risperidone etholakala kusixazululo Esijwayelekile;futhi F iyisici sokuphendula esihlobene sokungcola ngakunye okuhlobene ne-risperidone.Ngaphezu kokungeqi imikhawulo ekuThebula 1, akukho ngaphezu kuka-0.10% wanoma yikuphi ukungcola okungaziwa (sebenzisa inani elingu-F lika-1.0) elitholakalayo futhi akutholakali ngaphezu kuka-0.30% wengqikithi yokungcola.Unganaki iziqongo zokungcola ezingaphansi kuka-0.05%.
Ithebula 1
Isikhathi Sokugcina Esihlobene Nenhlanganisela Ehlobene (RRT) Isici Sempendulo Ehlobene (F) Umkhawulo (%)
I-E-oxime1 0.60 1.0 NMT 0.20
Z-oxime2 0.67 0.63 NMT 0.20
9-hydroxyrisperidone3 0.76 0.92 NMT 0.20
5-fluororisperidone4 0.94 1.0 NMT 0.20
I-Risperidone 1.0 1.0 -
6-methylrisperidone5 1.2 0.95 NMT 0.20
1 3-[2-[4-[(E)-(2,4-Difluorophenyl))(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
2 3-[2-[4-[(Z))-(2,4-Difluorophenyl)(hydroxyimino)methyl]piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H -pyrido[1,2-a]pyrimidin-4-one
3 (9RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-9-hydroxy-2-methyl-6,7,8 ,9-tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
4 3-[2-[4-(5-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-6,7,8,9-tetrahydro-4H-pyrido [1,2-a]pyrimidin-4-one
5 (6RS)-3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)piperidin-1-yl]ethyl]-2,6-dimethyl-6,7,8,9 -tetrahydro-4H-pyrido[1,2-a]pyrimidin-4-one
Isivivinyo-
Isixazululo se-buffer- Chaza u-15.4 g we-ammonium acetate ku-1 L yamanzi.Lungisa nge-acetic acid engu-10% uye ku-pH engu-6.5, bese uxuba.
Isixazululo A-Mix 100 mL wesixazululo se-Buffer no-150 mL we-methanol ku-1000-mL ye-volumetric flask, bese uhlanza ngamanzi ukuya kuvolumu.
Isixazululo B- Hlanganisa u-100 ml wesixazululo se-Buffer no-850 mL we-methanol ku-1000-mL ye-volumetric flask, bese uhlanza ngamanzi ngevolumu.
Isigaba seselula-Sebenzisa izingxube eziguquguqukayo zesisombululo A nesixazululo B njengoba kuqondiswe kusistimu yeChromatographic.Yenza izinguquko uma kudingeka (bona Ukufaneleka Kwesistimu ngaphansi kwe-Chromatography 621).
I-Diluent-Hlanganisa i-100 mL yesisombululo se-Buffer nama-900 mL amanzi kanye no-1000 mL we-methanol.
Isixazululo sokufaneleka kwesistimu-Lungisa isixazululo esingu-1 mg ngemL ngayinye ye-USP Risperidone System Suitability Mixture RS in Diluent.
Ukulungiselela okujwayelekile-Chaza inani elinembile lesisindo se-USP Risperidone RS ku-Diluent, futhi uhlambulule ngobuningi, futhi ngokwesinyathelo uma kunesidingo, nge-Diluent ukuze uthole isixazululo esinokugxila okwaziwayo okungaba ngu-1.0 mg nge-mL ngayinye.
Ukulungiselela i-Assay-Diluent ukuze uthole isixazululo esinesilinganiso esingaba ngu-1.0 mg nge-mL ngayinye.
Isistimu ye-Chromatographic (bona i-Chromatography <621>)- I-chromatograph ewuketshezi ifakwe umtshina ongu-275-nm kanye nekholomu engu-4.6-mm × 10-cm equkethe 3-µm ukupakisha L1.Izinga lokugeleza licishe libe ngu-1.5 mL ngomzuzu.Izinga lokushisa lekholomu ligcinwa liku-35. I-chromatograph ihlelwe kanje.
Isikhathi (imizuzu) Isixazululo A (%) Isixazululo B (%) Ukulinganisa
0–1 70 30 isokhrasi
1–20 70®5 30®95 i-gradient yomugqa
20–25 5 95 isokhrasi
25–27 5®70 95®30 i-gradient yomugqa
27–35 70 30 ukulinganisa kabushaJonga isisombululo sokufaneleka kohlelo.Rekhoda izimpendulo eziphezulu njengoba kuqondiswe kuNqubo, bese ukhomba iziqongo ngenxa ye-Z-oxime, i-9-hydroxyrisperidone, i-6-methylrisperidone, ne-risperidone usebenzisa izikhathi zokugcinwa okuhlobene (RRT) kusuka kuThebula 1;isixazululo, R, phakathi kwe-Z-oxime ne-9-hydroxyrisperidone ayikho ngaphansi kuka-2.8;isici somsila we-risperidone asikho ngaphezu kwe-1.5;futhi ukuchezuka okujwayelekile okuhlobene kwemijovo eyimpinda akubi ngaphezu kuka-2.0% kwenani eliphakeme le-risperidone.
Inqubo- Jova ngokwehlukana amavolumu alinganayo (cishe u-10 µL) wokulungiselela Okujwayelekile kanye nokulungiswa kwe-Assay ku-chromatograph, bese ukala izimpendulo zenani eliphakeme le-risperidone.Bala inani, ngamaphesenti we-C23H27FN4O2, engxenyeni ye-Risperidone ethathwe ifomula:
100(CS /CU)(rU / rS)
lapho i-CS ne-CU kuyizinto zokugxilisa, ngo-mg nge-mL ngayinye, ye-risperidone ekulungiseleleni Okujwayelekile kanye nokulungiselelwa kwe-Assay, ngokulandelanayo;futhi i-rU kanye ne-rS yizimpendulo eziphezulu ezitholakala ekulungiselelweni kwe-Assay nasekulungiseleleni Okujwayelekile, ngokulandelanayo.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
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R23/24/25 - Ubuthi ngokuhogela, ukuthintana nesikhumba futhi uma ugwinyiwe.
I-R11 - Ivutha Kakhulu
Incazelo Yokuphepha S28 - Ngemva kokuthinta isikhumba, geza ngokushesha ngensipho eningi.
I-S36 - Gqoka izingubo ezifanele zokuzivikela.
S45 - Uma kwenzeka ingozi noma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
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S16 - Gcina kude nemithombo yokuthungela.
Ama-ID e-UN 3249
I-WGK Germany 3
I-RTECS UV1164800
I-HS Code 2934999099
I-Hazard Class 6.1(a)
Ukupakisha Iqembu II
I-Risperidone (i-CAS: 106266-06-2) inomphumela wokuphikisa kuma-receptors we-5HT2 kanye nama-D2 receptors.I-Risperidone isetshenziselwa i-schizophrenia eyingozi futhi engapheli.Izidakamizwa ze-Antipsychotic.I-Risperidone isetshenziselwa ukwelapha i-schizophrenia eyingozi futhi engapheli kanye nezinye izimpawu ezicacile ze-psychotic (ezifana nokubona izinto ezingekho, ukukhohlisa, ukuphazamiseka kokucabanga, ubutha, ukusola) kanye nezimpawu ezimbi ezibalulekile (njengokungaphenduli, ukunganaki ngokomzwelo nokunganaki kwezenhlalo, ezimbalwa. amazwi).Futhi kungadambisa izimpawu ezithintekayo ezihlobene ne-schizophrenia (ezifana: ukucindezeleka, umuzwa wecala, ukukhathazeka).Ezigulini i-Risperidone esebenza ngempumelelo kuzo ukwelashwa okunamandla, esigabeni sokunakekela sokwelashwa, i-Risperidone ingaqhubeka nokudlala ukusebenza ngempumelelo kwayo emtholampilo.Ngakho-ke, i-Risperidone inesenzo sokwelapha kuzo zombili izimpawu ezinhle nezingezinhle ze-schizophrenia futhi ikhiqiza imiphumela engemihle embalwa kakhulu ikakhulukazi izimpawu ze-extrapyramidal uma kuqhathaniswa nama-antipsychotics ahlanzekile e-D2 avame ukusetshenziswa.Iphinde ibe namandla okulawula ukuhoxiswa kotshwala kanye nokuluthwa yi-cocaine.
