4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid CAS 123654-26-2 Prucalopride Succinate Intermediate Purity ≥98.0% (HPLC)
I-Shanghai Ruifu Chemical ingumkhiqizi ohamba phambili we-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Prucalopride Succinate Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid |
| Omqondofana | I-4-Amino-5-Chlorocoumaran-7-Carboxylic Acid;4-Amino-5-Chloro-2,3-Dihydrobenzo[b]furan-7-Carboxylic Acid;I-4-Amino-5-Chloro-2,3-Dihydro-1-Benzofuran-7-Carboxylic Acid;I-4-Amino-5-Chloro-2,3-Dihydro-7-Benzofurancarboxylic Acid;I-Prucalopride Ukungcola A;I-Prucalopride Succinate Ukungcola-2 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 123654-26-2 |
| I-Molecular Formula | I-C9H8ClNO3 |
| Isisindo samangqamuzana | 213.62 g/mol |
| I-Melting Point | 242℃(dec.) |
| Iphuzu elibilayo | 406.5±45.0℃ |
| Ukuminyana | 1.566 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate ye-Prucalopride Succinate (CAS: 179474-85-2) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Okuqinile Okumhlophe ukuya Kokubomvu Okukhanyayo | Okuqinile Okubomvu Okukhanyayo |
| Amanzi nguKarl Fischer | ≤1.00% | 0.35% |
| Izinsalela ekushiseni | <0.20% | 0.08% |
| Izinsimbi Ezisindayo (Pb) | ≤20ppm | <10ppm |
| Ukungcola Okukodwa | ≤1.00% | Iyahambisana |
| Ukungcola Okuphelele | ≤2.00% | Iyahambisana |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥98.0% (HPLC) | 99.6% |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| 1 H NMR Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Lo mkhiqizo yi-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid, okuqukethwe kwe-C12H12ClNO4 akufanele kube ngaphansi kuka-98.0%, kubalwe ngesisekelo se-anhydrous.
[Properties] Lo mkhiqizo uqinile ngokumhlophe ukuya kokubomvu ngokukhanyayo.
[Hlola]
Thatha inani elifanele lalo mkhiqizo (cishe u-0.5g) wamanzi, engeza i-solvent (i-methanol: N,N-dimethylformamide = 50:50), futhi uyihlakaze ngokuvumelana nendlela yokunquma amanzi (Isithasiselo Ⅷ M, indlela yokuqala A).Sebenzisa amaconsi okuhlola kaFisher ukuze unqume kuze kube yilapho isixazululo sishintsha ukusuka kokuphuzi ngokukhanyayo ukuya kokubomvu okunsundu okubonisa indawo yokugcina, futhi wenze olunye uhlolo olungenalutho.Bala ngokwefomula elandelayo: okuqukethwe kwamanzi akufanele kudlule i-1.00%.
Okuqukethwe umswakama (%) = (AB) F/W×100%
Lapho, A kuyivolumu yoketshezi lukaFisher olusetshenziswe umkhiqizo wokuhlola (ml);
B umthamo woketshezi lokuhlola lukaFisher oludliwe yisikhala esingenalutho, ml;
F yisisindo sesixazululo sokuhlola sikaFisher esilingana namanzi nge-1ml ngayinye, mg;
U-W isisindo somkhiqizo wokuhlola, mg
Into ehlobene
Ngokwendlela engaphansi kokuthi "Into yokulinganisa okuqukethwe", uma kukhona iziqongo zokungcola ku-chromatogram yesixazululo sokuhlola, indawo ephakemeyo yokungcola okukodwa akufanele ibe nkulu kunezikhathi eziyi-10 (1.0%) yendawo ephakeme kakhulu yokulawula. isixazululo, futhi isamba sendawo ephakeme kakhulu yakho konke ukungcola akufanele sibe ngaphezu kwezikhathi ezingama-20 (2.0%) endaweni ephakeme kakhulu yesixazululo sokulawula.
[Ukunqunywa Kokuqukethwe] Ngokusho kwe-chromatography yoketshezi esebenza kahle (Isithasiselo VI D).
Ijeli ye-silica ehlanganisiwe ye-Octadecylsilane isetshenziswe njengesigcwalisi sezimo ze-chromatographic nokuhlolwa kokufaneleka kwesistimu.Isixazululo se-Phosphate buffer (1.36g potassium dihydrogen phosphate, i-ultrasonic encibilikisiwe emanzini angu-1L, i-phosphoric acid elungiswe ku-PH 3.0) yasetshenziswa njengesigaba seselula A. I-Acetonitrile iyisigaba esihambayo B, futhi i-gradient elution yenziwa ngokwethebula elilandelayo:
Isikhathi (imizuzu) Isigaba sikamakhalekhukhwini A isigaba B
0 8020
15 80 20
30 50 50
45 50 50
Ubude bokutholwa bebungu-254 nm.Izinga lokugeleza lalingu-1.0 ml/min.Inani lamapuleti e-theoretical alikho ngaphansi kuka-2000 ngokusho kwenani eliphakeme le-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid
Inani eliphakeme le-furanoformic acid alikho ngaphansi kuka-2000.
Indlela yokunquma:
Thatha u-10mg womkhiqizo wokuhlola, uwukale ngokunembile, uwubeke ebhodleleni elingu-A 10ml, ulincibilikise nge-ultrasonic ngesigaba seselula A-mobile isigaba B (70:30) njengesincibilikisi, usihlambulule esikalini, unyakazise kahle, futhi ulungise isisombululo esine-concentration ye-1mg/ml.I-20 l yokunemba yajovwa ku-chromatograph ewuketshezi, futhi i-chromatogram yarekhodwa.Ukuhlanzeka okuphezulu okuphezulu bekungengaphansi kwama-98.0% ngokwendlela yokujwayelekile yendawo ephakeme
Ikholomu: I-Dionex Acclaim C18, 4.6*250mm, 5um
Izinga lokushisa lekholomu: 40 ℃
Izinga lokugeleza: 1.0ml/min
Ubude begagasi bokutholwa: 254nm
Usayizi wesampula: 10μL
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-4-Amino-5-Chloro-2,3-Dihydrobenzofuran-7-Carboxylic Acid (CAS: 123654-26-2), ingasetshenziswa njengendawo ephakathi yokuhlanganiswa kwe-Prucalopride Succinate (CAS: 179474-85-2), i-agonist ekhethiwe ye-5-HT4 receptor esetshenziswa ngempumelelo ukuqunjelwa okungapheli.I-Prucalopride Succinate, i-dihydrobenzofurancarboxamide ye-class-in-class, i-serotonin ekhethiwe (5-HT4) receptor agonist.Isidakamizwa, esimakethwe ngaphansi kwegama lomkhiqizo i-Resolor®, sinomsebenzi we-enterookinetic futhi sathuthukiswa inkampani yezemithi yaseBelgium i-Movetis.I-Prucalopride ishintsha amaphethini e-colonic motility nge-serotonin 5-HT4 receptor stimulation, icuphe amandla amaphakathi ashukumisayo wokuzikhulula.
