I-2-Cyanophenylboronic Acid 1,3-Propanediol Ester CAS 172732-52-4 Perampanel Intermediate Purity >99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) enekhwalithi ephezulu, ephakathi kwePerampanel (CAS: 380917-97-5).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Perampanel intermediates, Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-2-Cyanophenylboronic Acid 1,3-Propanediol Ester |
| Omqondofana | I-2-Cyanobenzeneboronic Acid 1,3-Propanediol Ester;2-(1,3,2-Dioxaborinan-2-yl)benzonitrile |
| Inombolo ye-CAS | 172732-52-4 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C10H10BNO2 |
| Isisindo samangqamuzana | 187.01 |
| I-Melting Point | 46.0~51.0℃ (okhanyisiwe) |
| Ukuminyana | 1.13±0.10 g/cm3 |
| Ukuncibilika | I-Soluble ku-Methanol |
| Ukuzinza | I-Hygroscopic |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Emhlophe Kuya Kuphuzi Ekhanyayo ukuya kuCrystal |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) |
| Ukulahlekelwa Ekumisweni | <0.50% |
| Izinsalela Ekushiseni | <0.20% |
| Ukungcola Okukodwa | <0.50% |
| Ukungcola Okuphelele | <1.00% |
| Izinsimbi Ezisindayo (njenge-Pb) | <20ppm |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Intermediate ye-Perampanel (CAS: 380917-97-5) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.
Izimpawu Zengozi Xi - Iyacasula
Amakhodi Engozi
R20/21/22 - Kuyingozi ngokuhogela, ukuthintana nesikhumba futhi uma ukugwinyile.
R36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
Incazelo Yokuphepha
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-S36/37/39 - Gqoka izingubo zokuzivikela ezifanele, amagilavu nokuvikela iso/ubuso.
Ama-ID e-UN 3439
I-WGK Germany 3
Inombolo yomthetho ye-TSCA
I-Hazard Note Irritant
I-2-Cyanophenylboronic Acid 1,3-Propanediol Ester (CAS: 172732-52-4) isetshenziselwa ukuhlanganiswa kwePerampanel (CAS: 380917-97-5), umphikisi we-AMPA receptor.IPerampanel (inikezwe ilayisense ngo-2012) iyisizukulwane sesithathu i-AED eyaziwa ngegama lobunikazi be-Fycompa® (Eisai, Hatfield) e-UK kanye ne-Banzel® (Eisai, Hatfield) e-USA.Ngo-Okthoba 2012, i-US FDA igunyaze i-perampanel yokwelashwa kokuquleka okuncane ezigulini ezinesifo sokuwa okungenani ezineminyaka eyi-12 ubudala.U-Perampanel ungumphikisi wokuqala wamamukeli we-AMPA ukuthola imvume ye-FDA njenge-AED.Ama-AMPA glutamate receptors atholakala ngokuyinhloko kuma-postsynaptic neurons ebuchosheni.Njengombangi okhethiwe, ongancintisani we-AMPA, i-parampanel ivimbela ukuvulwa kwesiteshi se-ion futhi yehlisa ukusabalala kwamandla esenzo.I-Perampanel yavunywa yi-European EMA kanye ne-US FDA ngoJulayi no-Okthoba 2012 ngokulandelana, isetshenziselwa ukwelashwa kwe-adjuvant ezigulini ezinokuquleka ingxenye engaphezu kweminyaka engu-12 ubudala noma ngaphandle kokuquleka kwesibili kwesistimu.Ngomhla zingama-22 kuNhlangulana wezi-2015, u-Eisai wamemezela ukuthi i-FDA yase-US igunyaze ukunwetshwa kwenkomba ye-Pirenparanide hydrate (Fycompa) njengokwelashwa okuhambisanayo kokuquleka okuyisisekelo kwe-tonic-clonic ezigulini ezinesifo sokuwa esineminyaka engu-12 nangaphezulu.
