I-CAS 177036-94-1 Purity >99.0% (HPLC) Isithombe Esifakiwe Sefekthri ye-API High Purity

I-CAS 177036-94-1 Purity >99.0% (HPLC) API Factory High Purity

Incazelo emfushane:

I-CAS: 177036-94-1

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Impushana Emhlophe noma Engamhlophe

Ukwelashwa kwe-Pulmonary Arterial Hypertension (PAH)

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Ukunikezwa Kwezentengiselwano (CAS: 177036-94-1) Abaphakathi Abahlobene:
I-CAS: 177036-94-1
I-Methyl 2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoate CAS: 178306-47-3
I-2-Hydroxy-3-Methoxy-3,3-Diphenylpropanoic Acid CAS: 178306-51-9
(S)-2-Hydroxy-3-Methoxy-3,3-Diphenylpropionic Acid CAS: 178306-52-0
I-L-Proline Methyl Ester Hydrochlorid CAS: 2133-40-6
4,6-Dimethyl-2-(Methylsulfonyl)pyrimidine CAS: 35144-22-0

Chemical Properties:

Igama Lekhemikhali	(S)-2-[(4,6-Dimethylpyrimidin-2-yl)oxy]-3-Methoxy-3,3-Diphenylpropionic Acid
Omqondofana	(+-)-(2S)-2-((4,6-Dimethylpyrimidin-2-yl)oxy)-3-Methoxy-3,3-Diphenylpropanoic Acid
Inombolo ye-CAS	177036-94-1
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C22H22N2O4
Isisindo samangqamuzana	378.43
Ukuzungezisa Okuthile [α]D20	+170.0° ukuya ku-+176.0° (C=0.5, MeOH)
I-Melting Point	172.0~178.0℃(dec.)
Ukuncibilika	I-Soluble Kakhulu ku-Methanol;Incibilika ku-Ethanol, i-acetone;Ayincibiliki Emanzini
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe noma Engamhlophe
Ukuhlonza	I-HPLC;I-NMR;I-LC-MS
Izinto Ezihlobene
Ukungcola Ngamunye	≤0.50%
Ukungcola Okuphelele	<1.00%
Ukulahlekelwa Ekumisweni	≤0.50%
Izinsalela ekushiseni	≤0.20%
Izinsimbi Ezisindayo	≤20ppm
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	Pharmaceutical Intermediates

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

(CAS: 177036-94-1) APIingumphikisi we-endothelin-A (ETA) okhethiwe owethulwa ukwelashwa ngomlomo kweziguli ezine-pulmonary arterial hypertension (PAH), ukuthuthukisa umthamo wokuzivocavoca nokubambezela ukuwohloka komtholampilo.I-PAH iyisifo esingavamile semithanjeni emincane yamaphaphu ebonakala ngokukhula kwe-vascular kanye nokulungiswa kabusha, okuholela ekwandeni okuqhubekayo kwe-pulmonary vascular resistance kanye ne-pulmonary arterial pressure, futhi ekugcineni, ukwehluleka kwe-ventricular kwesokudla nokufa ngaphambi kwesikhathi.Izimpawu zakuqala ze-PAH zihlanganisa ukuphelelwa umoya kancane kancane, ukukhathala, ukushaya kwenhliziyo, ukuquleka, nokuquleka.I-Endothelin-1 (ET-1), i-vasoconstrictor enamandla kanye ne-mitogen yemisipha ebushelelezi, ibambe iqhaza elibalulekile ekusheshiseni lesi sifo, futhi imiphumela yaso ilamula ngokusebenza kwe-ETA kanye ne-ETB receptors.NgoJuni ka-2007, i-FDA yanikeza imvume (CAS: 177036-94-1) API yokwelashwa kanye ngosuku kwe-PAH.