1-(3-Methoxypropyl)-4-Piperidinamine CAS 179474-79-4 Prucalopride Succinate Intermediate Purity >98.0% (GC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-1-(3-Methoxypropyl)-4-Piperidinamine (CAS: 179474-79-4) enekhwalithi ephezulu, emaphakathi ye-Prucalopride Succinate (CAS: 179474-85-2) .I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-1-(3-Methoxypropyl)-4-Piperidinamine,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-1-(3-Methoxypropyl) -4-Piperidinamine |
| Omqondofana | 1-(3-Methoxypropyl)piperidin-4-Amine;4-Amino-1-(3-Methoxypropyl)piperidine;I-Prucalopride Succinate Intermediate B;I-Prucalopride ephakathi B;I-Prucalopride Ukungcola 17 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 179474-79-4 |
| I-Molecular Formula | I-C9H20N2O |
| Isisindo samangqamuzana | 172.27 g/mol |
| Iphuzu elibilayo | 249℃ |
| I-Flash Point | 105℃ |
| Ukuminyana | 0.946 g/cm3 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Ukuthumela ngomkhumbi | Okuvamile |
| Isigaba | I-Intermediate ye-Prucalopride Succinate (CAS: 179474-85-2) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Uketshezi Olungenambala Kuya Kuphuzi Olukhanyayo | Uketshezi Olungenambala |
| Amanzi nguKarl Fischer | <0.50% | 0.25% |
| Ukungcola Okukodwa | <0.50% | 0.11% |
| Ukungcola Okuphelele | <2.00% | 0.70% |
| Ukuhlanzeka / Indlela Yokuhlaziya | >98.0% (GC) | 99.3% |
| 1 H NMR Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe | |
Iphakheji:Ibhodlela, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Lo mkhiqizo yi-1-(3-Methoxypropyl) -4-Piperidinamine.Iqukethe i-C9H20N2O ngeke ibe Ngaphansi kuka-98.0%, kubalwe ngesisekelo se-anhydrous.
[Izakhiwo: Lo mkhiqizo awunambala kuya kuketshezi oluphuzi olukhanyayo.
Thatha inani elifanele lamanzi alo mkhiqizo, engeza i-solvent (i-methanol), uyincibilikise, uyinqume ngokwendlela yokunquma amanzi (Isithasiselo Ⅷ M, indlela yokuqala A), sebenzisa amaconsi okuhlola kaFisher ukuze unqume kuze kube yilapho isixazululo sishintsha sisuka kokuphuzi ngokukhanyayo. kunsundu obomvu okubonisa indawo yokugcina, bese wenza olunye uhlolo olungenalutho.Bala ngokwefomula elandelayo: okuqukethwe kwamanzi akufanele kudlule i-1.0%.
Okuqukethwe umswakama (%) = (AB) F/W×100%
Lapho, A kuyivolumu yoketshezi lukaFisher olusetshenziswe umkhiqizo wokuhlola (ml);
B umthamo woketshezi lokuhlola lukaFisher oludliwe yisikhala esingenalutho, ml;
F yisisindo sesixazululo sokuhlola sikaFisher esilingana namanzi nge-1ml ngayinye, mg;
U-W isisindo somkhiqizo wokuhlola, mg
Ukungcola okukodwa
Ngokwezimo zokuthola nezindlela ezingaphansi [kokunqunywa kokuqukethwe], i-chromatogram yarekhodwa futhi isikhathi sokugcinwa sisuka esiqongweni esiyinhloko saba izikhathi ezingu-3.Uma kunenani eliphakeme lokungcola esixazululweni sokuhlola, ukungcola okukodwa akumele kube ngaphezu kuka-0.5% futhi isamba sakho konke ukungcola akumele sibe ngaphezu kuka-2.0% ngokwendlela yokwenza indawo evamile.
[Ukunqunywa Kokuqukethwe] Ngokwendlela yokunquma incibilikayo eyinsalela (Isithasiselo Ⅷ P)
(6%) i-cyanopropyl phenyl - (94%) i-dimethylpolysiloxane (noma i-polarity efanayo) njengekholomu ye-capillary ewuketshezi engashintshi;
Indlela yokufudumala ehleliwe yesistimu yesampula ye-capillary headspace enemibandela ye-gas chromatographic yasetshenziswa.Izinga lokushisa lokuqala lalingu-100℃ ngemizuzu engu-5, futhi izinga lokushisa lanyuswa ku-15℃ ngomzuzu laya ku-250℃ ngemizuzu emi-4.Izinga lokushisa lokungena lalingu-250 ℃, futhi izinga lokushisa lomtshina lalingu-280 ℃.Izinga lokugeleza lalingu-4ml/min.Isilinganiso se-shunt singu-8: 1.
Cishe i-0.6g yalo mkhiqizo yathathwa, ikalwa ngokunembile, yafakwa ebhodleleni le-10ml, yachithwa nge-methanol futhi yahlanjululwa esikalini, njengesixazululo somkhiqizo wokuhlola.Isixazululo sesampula sajovwa nge-1μl okungenani izikhathi ezimbili zilandelana, ngokulandelana.Indawo ephakeme kunazo zonke ezokalwa yanqunywa.Ukuhlanzeka okuphezulu okuphezulu bekungengaphansi kwama-98.0% ngokwendlela yokujwayelekile yendawo ephakeme.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-1-(3-Methoxypropyl) -4-Piperidinamine (CAS: 179474-79-4) iyisisetshenziswa esiphakathi sokwenziwa esiwusizo ekuhlanganiseni kwePrucalopride Succinate (CAS: 179474-85-2).I-Prucalopride iyi-agonist ekhethiwe ye-5-HT4 receptor esetshenziswa ngempumelelo ekuqunjweni okungapheli, kodwa okwamanje ayigunyazwanga e-US I-Prucalopride igunyazelwe ukwelashwa kokuqunjelwa okungapheli eYurophu.I-Prucalopride succinate, i-dihydrobenzofurancarboxamide yesigaba sokuqala, i-serotonin ekhethiwe (5-HT4) receptor agonist.Isidakamizwa, esimakethwe ngaphansi kwegama lomkhiqizo i-Resolor®, sinomsebenzi we-enterookinetic futhi sathuthukiswa inkampani yezemithi yaseBelgium i-Movetis.I-Prucalopride ishintsha amaphethini e-colonic motility nge-serotonin 5-HT4 receptor stimulation, icuphe amandla amaphakathi ashukumisayo wokuzikhulula.
