I-Gefitinib Intermediate CAS 199327-61-2 Ubumsulwa >99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-7-Methoxy-6-(3-Morpholin-4-ylpropoxy)quinazolin-4(3H)-One (CAS: 199327-61-2) enekhwalithi ephezulu, emaphakathi. yeGefitinib (CAS: 184475-35-2).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Gefitinib Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 7-Methoxy-6-(3-Morpholin-4-ylpropoxy)quinazolin-4(3H)-One |
| Omqondofana | 7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4(3H)-One;7-Methoxy-6-[3-(4-Morpholinyl) propoxy]-4(3H)-Quinazolinone;7-Methoxy-6-(3-Morpholinopropoxy)quinazolin-4-One |
| ukungcola | Gefitinib ukungcola 5;Gefitinib EP Ukungcola A |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 199327-61-2 |
| I-Molecular Formula | I-C16H21N3O4 |
| Isisindo samangqamuzana | 319.36 g/mol |
| I-Melting Point | 242.0~247.0℃ |
| Ukuminyana | 1.32±0.10 g/cm3 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Impushana Emhlophe Kuya Kumhlophe | Iyahambisana |
| I-Melting Point | 242.0~247.0℃ | 243.6 ~ 244.5℃ |
| Ukulahlekelwa Ekumisweni | <0.50% | 0.15% |
| Izinsalela ekushiseni | <0.20% | 0.11% |
| Ukungcola Okukodwa | <0.50% | <0.30% |
| Ukungcola Okuphelele | <1.00% | 0.30% |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) | 99.7% |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
| Isicelo | I-Intermediate ye-Gefitinib (CAS: 184475-35-2) | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-7-Methoxy-6- (3-Morpholin-4-ylpropoxy)quinazolin-4 (3H)-One (CAS: 199327-61-2) iphakathi / ukungcola kwe-Gefitinib (CAS: 184475-35-2).I-Gefitinib iyisidakamizwa esiqondiswe kakhulu esilwa nesimila esakhiwe ngabakwa-AstraZeneca, e-UK.I-Gefitinib umuthi wokuqala oqondiswe kumangqamuzana wokwelapha umdlavuza wamaphaphu wamangqamuzana ongewona omncane.Isebenza ngokuvimbela ngokukhetha indlela yokudlulisa isignali ye-epidermal growth factor receptor tyrosine kinase (EGFR-TK).Ngo-Agasti 2002, i-Gefitinib yaqala ukukhangiswa e-Japan njengendlela yokwelapha yomugqa wokuqala yomdlavuza wamaphaphu ongewona omncane ngaphansi kwegama lokuhweba elithi Iressa.NgoMeyi 2003, i-US Food and Drug Administration yagunyaza i-Gefitinib njenge-monotherapy yomugqa wesithathu yeziguli ezinomdlavuza wamaphaphu ongewona omncane wamangqamuzana ezazingasebenzi ngemithi elwa nomdlavuza esekelwe ku-platinum kanye ne-docetaxel chemotherapy.Njengamanje, i-Gefitinib igunyazwe yi-Australia, Japan, Argentina, Singapore kanye neNingizimu Korea ukuze kwelashwe umdlavuza wamaphaphu ongewona omncane.Ngomhla zingama-28 kuNhlolanja wezi-2005, i-China Food and Drug Administration igunyaze i-Gefitinib yokwelapha umdlavuza wamaphaphu wamaphaphu osethuthuke endaweni noma ongewona omncane we-metastatic (NSCLC) owawuthole ukwelashwa ngamakhemikhali ngaphambilini.Okwamanje ayigunyaziwe ukuthi isetshenziswe njengokwelashwa komugqa wokuqala we-NSCLC ethuthukisiwe.Ngomhla zi-1 kuJulayi, 2009, i-European Medicines Agency yagunyaza ngokusemthethweni i-Gefitinib yokwelashwa komugqa wokuqala, umugqa wesibili kanye nomugqa wesithathu womdlavuza wamaphaphu othuthukisiwe wasendaweni noma ongewona omncane we-metastatic nokuguqulwa kofuzo kwe-EGFR kubantu abadala.
