I-Vardenafil Intermediate CAS 224789-21-3 Ubumsulwa >99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (I-CAS: 224789-21-3) enekhwalithi ephezulu, ephakathi kwe-Vardenafil.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Vardenafil Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one |
| Omqondofana | I-Vardenafil Dessulfonyl Ukungcola;2-(2-Ethoxyphenyl)-5-Methyl-7-Propyl-3H-Imidazo[5,1-F][1,2,4]triazin-4-one;I-Vardenafil Propyl Imidazotriazinone Ukungcola;I-Vardenafil Inhlanganisela Ehlobene 1 |
| Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani angu-2 ngenyanga |
| Inombolo ye-CAS | 224789-21-3 |
| I-Molecular Formula | I-C17H20N4O2 |
| Isisindo samangqamuzana | 312.37 g/mol |
| I-Melting Point | 142.0~148.0℃ |
| Ukuminyana | 1.26±0.10 g/cm3 |
| Isitoreji Sesikhathi Eside | Indawo epholile neyomile (2~8℃) |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Okumhlophe Okumhlophe kuya Kuphuphu Ophuzi Okuphaphathekile | I-Off-White Powder |
| I-Melting Point | 142.0~148.0℃ | 146.0 ~ 147.0℃ |
| Ukulahlekelwa Ekumisweni | <1.00% (102℃, 3h) | 0.23% |
| Izinsimbi Ezisindayo (Pb) | ≤20ppm | <20ppm |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) | 99.79% |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
| Isicelo | Okuphakathi kweVardenafil / Vardenafil Hydrochloride | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela elangeni kanye nomswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
1. Ukubukeka: Beka isampula ephepheni elimhlophe bese ubheka ukubukeka, okumhlophe-mhlophe ukuya kumpushana ophuzi ophaphathekile.
2. Ukuhlaziya:
2.1 Ukunqunywa Kwendawo Encibilikayo ngokomthetho (Chinese Pharmacopoeia 2010 Edition II Appendix ⅥC) Indawo encibilikayo ngu-142.0~148.0℃.
2.2 Ukulahlekelwa Ekomisweni: Ukunqunywa ngokomthetho (Isithasiselo ⅧL, Ingxenye II, Uhlelo luka-2010 lwe-Chinese Pharmacopoeia).Ukunemba okukala inani elifanele lalo mkhiqizo, omile ku-102 ℃ amahora angu-3, ukuncipha kwesisindo akufanele kube ngaphezu kuka-1.00%.
2.3 Izinsimbi Ezisindayo: Ukunqunywa ngokomthetho (Ushicilelo lwe-People's Republic of China Pharmacopoeia 2010, Ingxenye II Isithasiselo ⅧH) Ukunqunywa ngendlela yesibili.
Ukunemba kukala u-1.0g womkhiqizo wokuhlola, uvutha kancane kuze kube yilapho u-carbonized ngokuphelele, upholile, engeza u-0.5-1.0ml sulfuric acid, wenze kube nomswakama, ukushisa ekushiseni okuphansi kuze kube yilapho i-sulfuric acid iphelile, engeza u-0.5ml nitric acid, umusi owomile, kuze kube yilapho. umhwamuko we-nitrogen oxide uphelile, upholile, ushisa ku-500-600 ℃ ukuze ube ne-carbonized ngokuphelele, upholile, engeza u-2ml hydrochloric acid, Ngemva kokumisa emanzini okugeza, engeza amanzi angu-15ml, uphonsa isisombululo sokuhlola i-ammonia kuze kube yilapho ingathathi hlangothi kunkomba ye-phenolphthalein. isixazululo, engeza u-2ml we-acetate buffer (ph3.5), bese uncibilikisa ukushisa kancane, ukuyise kushubhu ye-Nachner colorimetric, futhi uyihlambulule ibe ngu-25ml ngamanzi.Thatha enye i-reagent yokulungisa isisombululo sokuhlola, futhi usishise esitsheni se-porcelain, engeza i-2ml ye-acetate buffer (PH3.5) namanzi angu-15ml ekushiseni kancane Ngemva kokuhlakazeka, hambisa ithubhu le-Nath colorimetric, engeza inani elithile lesisombululo sokuhola esijwayelekile, bese uhlanza ngamanzi ku-25ml.Ukuhlolwa kwe-colorimetric kwenziwa phakathi kwesixazululo sokuhlola nesixazululo esijwayelekile esingatholwa.Ukulungiswa kwesixazululo okujwayelekile ngokuya nge-(People's Republic of China Pharmacopoeia 2010 edix II Isithasiselo Ⅷ Indlela yokuhlola insimbi esindayo) indlela yokuqala.Izinsimbi ezisindayo akumele zeqe izingxenye ezingama-20 ngesigidi.
3. Ubumsulwa: Ngokokusebenza okuphezulu kwe-chromatography yoketshezi, kunqunywa ngokomthetho (Chinese Pharmacopoeia 2010 edition II Appendix VD).
Izimo zeChromatographic:
Ikholomu: C18, 200mm×4.6mm, 5μm;
Isigaba seselula: I-Phosphate buffer (isisindo esingu-2.72g se-potassium dihydrogen phosphate, engeza amanzi azoncibilika futhi ahlanjululwe abe ngu-1000ml, lungisa i-pH=3.5) : i-acetonitrile: = 35:65;
Ubude begagasi bokubona: 254nm;
Izinga lokugeleza: 1.0ml/min.
Indlela yokunquma: Thatha cishe u-30mg walo mkhiqizo, uwukale ngokunembile, uwuhlambulule ngesigaba esihambayo ukuze wenze ukugxila kucishe kube ngu-0.3mg/ml, thatha u-20μl ungene ku-chromatograph ewuketshezi, urekhode ichromatogram.Ngokwendlela yokujwayelekile yendawo, ubumsulwa abukho ngaphansi kwama-99.0%.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-2-(2-Ethoxyphenyl)-5-Methyl-7-Propylimidazo[5,1-F][1,2,4]triazin-4(3H)-one (CAS: 224789-21-3) imaphakathi I-Vardenafil (CAS: 224785-90-4) / Vardenafil Hydrochloride (CAS: 224785-91-5).I-Vardenafil iyi-PDE5 inhibitor entsha eyethulwe ukwelashwa ngomlomo kokungasebenzi kahle kwe-erectile yesilisa futhi inokufana okuphawulekayo kwesakhiwo ne-sildenafil (i-Viagra), okwakuyi-PDE5 inhibitor yokuqala eyethulwa ku-1998 ngenxa yalesi sibonakaliso.
U-Vardenafil wayeyi-ejenti yesibili okufanele idayiswe futhi ibe nenzuzo yokuthi isikhathi sayo sokuqala asizange sincishiswe ngokuthatha imithi esiswini esigcwele.Inamandla izikhathi ezingu-30 njenge-inhibitor ye-PDE5 (isho i-IC50, i-3.9 nM) kune-sildenafil futhi inamandla izikhathi ezingu-10 kune-tadalafil, ngokukhetha okukhulu (>izikhathi ezingu-1,000) ku-PDE5 yomuntu kune-PDE2, i-PDE3, ne-PDE4 yabantu kanye ukukhetha okumaphakathi (>izikhathi ezingama-80) ze-PDE1.I-PDE inhibitory selectivity kanye nakho kokubili amandla e-in vitro kanye ne-vivo ye-PDE5 inhibitor vardenafil entsha.I-Vardenafil ivimbele ngokuqondile i-hydrolysis ye-cGMP nge-PDE5, nge-IC50 ye-0.7 nM (sildenafil 6.6 nM).I-IC50 ye-vardenafil ye-PDE1 yayingu-180 nM, ye-PDE6 11 nM, futhi ye-PDE2, PDE3 kanye ne-PDE4 ngaphezu kuka-1,000 nM.
