I-Lapatinib Base CAS 231277-92-2 Purity ≥99.0% (HPLC)

Incazelo emfushane:

Igama Lekhemikhali:I-Lapatinib Base

I-CAS: 231277-92-2

Ubumsulwa: ≥99.5% (HPLC)

Cishe I-Crystalline Powder Emhlophe noma Ephuzi Ekhanyayo

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

I-Lapatinib Intermediates:

I-Lapatinib Base	I-CAS 231277-92-2
I-Lapatinib Ditosylate Monohydrate	I-CAS 388082-78-8
I-Sodium Methanesulfinate	I-CAS 20277-69-4
3-Chloro-4-(3-Fluorobenzyloxy)aniline	I-CAS 202197-26-0
2-Aminoethyl Methyl Sulfone Hydrochloride	I-CAS 104458-24-4
4-Chloro-6-Iodoquinazoline	I-CAS 98556-31-1
6-Iodo-4-Hydroxyquinazoline	I-CAS 16064-08-7
I-5-Formyl-2-Furanboronic Acid	I-CAS 27329-70-0
5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde	I-CAS 231278-84-5

Chemical Properties:

Igama Lekhemikhali	I-Lapatinib Base
Omqondofana	I-Lapatinib;N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[(2-(methylsulfonyl)ethyl]amino]methyl]furan-2-yl]quinazolin-4-amine N-[3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl]-6-[5-[[[2-(methylsulfonyl)ethyl]amino]methyl]-2-furyl]-4-quinazolinamine
Inombolo ye-CAS	231277-92-2
Isimo Sesitoko	Kukhona kusitoki
I-Molecular Formula	I-C29H26ClFN4O4S
Isisindo samangqamuzana	581.06
I-Melting Point	141.0~149.0℃
Ukuminyana	1.381±0.06 g/cm3
I-COA ne-MSDS	Iyatholakala
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Cishe I-Crystalline Powder Emhlophe noma Ephuzi Ekhanyayo
Ukuhlonza	I-IR;I-HPLC
Ukuhlanzeka / Indlela Yokuhlaziya	≥99.0% (HPLC)
I-Melting Point	141.0~149.0℃
Ukulahlekelwa Ekumisweni	≤0.50%
Izinsalela ekushiseni	≤0.10%
Izinsimbi Ezisindayo (njenge-Pb)	≤20ppm
Ukungcola Okuguquguqukayo Kwezinto Eziphilayo	Hlangana Nemfuneko
Izinto Ezihlobene
Ukungcola Okukodwa	≤0.30%
Ukungcola Okuphelele	≤1.00%
Izinga Lokuhlola	I-Enterprise Standard
I-Shelf Life	Iminyaka engu-2 Lapho Igcinwe Ngokufanele
Ukusetshenziswa	I-API, Ukwelashwa Ngomlomo Komdlavuza Webele

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

231277-92-2 - Isicelo:

I-API (CAS: 231277-92-2)iwukwelapha okuhlosiwe kwesidakamizwa somdlavuza webele, iyi-tyrosine kinase inhibitor, ingavimbela ngempumelelo i-human epidermal growth factor receptor -1 (ErbB1) kanye ne-human epidermal growth factor receptor (ErbB2) umsebenzi we-tyrosine kinase we -2.Iyingqayizivele ngoba ingadlala indima ngezindlela ezihlukahlukene, ukuze amangqamuzana omdlavuza webele angakwazi ukuthola isignali edingekayo ekukhuleni.Indlela yesenzo ukuvimbela i-intracellular EGFR (ErbB-1) kanye ne-HER2 (ErbB-2) amasayithi we-ATP ukuvimbela i-phosphorylation nokusebenza kwamangqamuzana e-tumor, kanye nokuvimbela ukulawulwa phansi kokusayina nge-EGFR (ErbB-1) kanye I-HER2 (ErbB-1) i-homogeneous ne-heterogeneous ama-aggregate amabili.Inhlanganisela ye-(CAS: 231277-92-2) ne-Capecitabine isetshenziselwa ukwelapha iziguli ezinomdlavuza webele othuthukisiwe noma we-metastatic nge-overexpression ye-human epidermal receptor2, esivele selashwe nge-anthracyclines, i-paclitaxel, ne-trastuzumab.Izivivinyo zemitholampilo zibonise ukuthi iphinde yelapha ngempumelelo iziguli zomdlavuza wohlobo lwe-HER2 ezinokumelana ne-Herceptin.

231277-92-2 - Izinkomba:

I-Lapatinib ihlanganiswe ne-Capecitabine ifaneleka ekwelapheni iziguli ezinomdlavuza webele osethuthukile noma we-metastatic nge-HER2(ErbB-2 overexpression) kanye nokwelashwa kwangaphambilini okuhlanganisa i-anthracyclines, i-paclitaxel ne-trastuzumab.

231277-92-2 - Ukusebenzisana Kwezidakamizwa:

Amaphilisi e-in vitro Lapatinib angavimbela i-CYP3A4 ne-CYP2C8 ekugxilweni kokwelapha, futhi ikakhulukazi i-metabolism yi-CYP3A4.izidakamizwa ezivimbela lo msebenzi we-enzyme zingandisa kakhulu ukuhlushwa kwezidakamizwa zegazi zeLapatinib.I-Ketoconazole, engu-0.2g isikhathi ngasinye, izikhathi ezi-2/d, ingakhuphula i-AUC ye-Lapatinib izikhathi ezi-3–7 futhi yelule isigamu sempilo izikhathi ezingu-1.7 ngemva kwezinsuku ezingu-7.Amavolontiya anempilo athatha i-CYP3A4 inducer ngomlomo, 100 mg isikhathi ngasinye, kabili ngosuku, futhi ashintshela ku-200mg isikhathi ngasinye ngemva kwezinsuku ezingu-3, ukwabelana ngezinsuku ezingu-17 kabili ngosuku.I-AUC yeLapatinib yehle ngo-72%.I-Lapatinib iyindawo yokuthutha ye-P-glycoprotein, futhi izidakamizwa ezivimbela i-glycoprotein zingase zandise ukugcwala kwegazi komuthi.

Umuthi Omusha Wokwelashwa Okuhlosiwe Komdlavuza Webele:

I-Lapatinib umuthi omusha wokwelapha okuhlosiwe womdlavuza webele othuthukiswe yi-GlaxoSmithKline, UK.Kuyi-tyrosine kinase inhibitor engavimbela ngempumelelo i-human epidermal growth factor receptor -1(ErbB1) kanye ne-human epidermal growth factor receptor -2(ErbB2) umsebenzi we-tyrosine kinase.Iyingqayizivele ngoba ingasebenza ngezindlela ezihlukahlukene ukuze amangqamuzana omdlavuza webele angakwazi ukuthola izimpawu ezidingekayo ekukhuleni.Indlela yesenzo ukuvimbela amasayithi e-ATP e-EGFR(ErbB-1) kanye ne-HER2(ErbB-2) kumaseli ukuvimbela i-phosphorylation nokusebenza kwamangqamuzana esimila, kanye nokuvimba amasiginali wokulawula phansi ngokusebenzisa ama-homogenous and heterogeneous dimers we-EGFR(ErbB). -1) kanye ne-HER2(ErbB-1).Ukwelashwa okuhloswe ngamangqamuzana omdlavuza webele kubhekisela ekwelapheni ama-oncogenes kanye nemikhiqizo yokukhuluma ehlobene ehlobene nokuvela nokukhula komdlavuza webele.Izidakamizwa eziqondiswe kumamolekyuli zivimbela noma zibulale amaseli wesimila ngokuvimbela ukudluliselwa kwesignali kumaseli wesimila noma amaseli ahlobene ukuze alawule izinguquko ekukhulumeni kofuzo lweseli.ngo-March 14, 2007, ukudla kwase-US kanye nokuphathwa kwezidakamizwa kugunyaze inhlanganisela ye-lapatinib ne-xeloda (capecitabine) yokwelashwa kweziguli ezinomdlavuza webele osezingeni eliphezulu noma we-metastatic ovezwe ngokweqile yi-human epidermal factor receptor 2 (ErbB2) futhi welashwa nge-anthracyclines, paclitaxel kanye ne-trastuzumab. .Izivivinyo zemitholampilo zibonisa ukuthi lo mkhiqizo futhi unemiphumela emihle yomtholampilo ezigulini ezinomdlavuza webele we-HER2 eziye zakwazi ukumelana nezidakamizwa ku-Roche's Herceptin (Herceptin).i-lapatinib iyisidakamizwa esisha esihlosiwe sokulwa nomdlavuza.Ingenza izinto ezihloswe ngu-Her-1 kanye ne-Her-2 ngesikhathi esisodwa.Umthelela webhayoloji wale ndlela yesenzo ekwandeni nasekukhuleni kwamaseli wesimila mkhulu kakhulu kunalowo wethagethi eyodwa kuphela.Okubizwa ngemithi yokwelapha okuhlosiwe ibhekisela ezidakamizweni ezisebenzisa ama-receptors athile, izakhi zofuzo noma amaprotheni angukhiye njengezinhloso zokubulala amaseli wesimila ahlobene ngendlela eqondiwe.