I-Lapatinib Intermediate CAS 231278-84-5 Purity >98.0% (HPLC)
Igama Lekhemikhali | 5-[4-[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde |
Omqondofana | I-Lapatinib Ephakathi 3;5-[4-[[3-Chloro-4-[(3-Fluorophenyl)methoxy]phenyl]amino]-6-Quinazolinyl]-2-Furancarboxaldehyde;5-[4-((3-Chloro-4-((3-Fluorobenzyl)oxy)phenyl)amino)quinazolin-6-yl]-2-Furaldehyde |
Inombolo ye-CAS | 231278-84-5 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C26H17ClFN3O3 |
Isisindo samangqamuzana | 473.90 |
I-Melting Point | 225.0 ukuze 235.0 ℃ |
Ukuminyana | 1.407±0.06 g/cm3 |
I-Refractive Index | 1.694 |
I-COA ne-MSDS | Iyatholakala |
Umsuka | Shanghai, China |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Eqinile Ephuzi Okuphuzi ukuya Kuphuzi |
Ukuhlanzeka / Indlela Yokuhlaziya | >98.0% (HPLC) |
I-Melting Point | 225.0~235.0℃ |
Ukulahlekelwa Ekumisweni | <1.00% |
Izinsalela Ekushiseni | <0.50% |
Ukungcola Okuphelele | <2.00% |
Izinsimbi Ezisindayo (njenge-Pb) | <20ppm |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Intermediate of API (CAS 388082-77-7) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
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I-5--[4--[3-Chloro-4-(3-Fluorobenzyloxy)anilino]-6-Quinazolinyl]furan-2-Carboxaldehyde (CAS: 231278-84-5) iphakathi kwe-API (CAS 388082-77-7 ).(i-CAS 388082-77-7) iyisidakamizwa esiqondise umdlavuza webele esakhiwe yi-British GlaxoSmithKline Co. Kuyi-tyrosine kinase inhibitor engavimbela ngempumelelo umsebenzi we-tyrosine kinase we- human epidermal growth factor receptors 1 kanye ne-2 (ErbB1, ErbB2).Ingenza ngokuhlukile ngezindlela ezihlukahlukene, iqinisekise ukuthi amangqamuzana omdlavuza webele awakwazi ukuthola izimpawu zokukhula.Ivimbela i-intracellular EGFR (ErbB-1) kanye ne-HER2 (ErbB-2) amasayithi e-ATP, ivimbela i-tumor cell phosphorylation nokusebenza, ivimbela amasignali okulawula phansi ngokusebenzisa i-homogeneity kanye ne-heterogeneity ye-EGFR (ErbB-1) ne-HER2 (ErbB-1) i-dimerization.
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