![I-Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC) Isithombe Esifakiwe](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_.jpg)
I-Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)
I-Ruifu Chemical ingumhlinzeki oholayo we-Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) enekhwalithi ephezulu, emaphakathi ye-Apixaban (CAS: 503612-47-3).I-Ruifu inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, amanani amancane nayinqwaba atholakalayo.Thenga i-Apixaban intermediates, i-E-mail: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate |
| Omqondofana | I-Ethyl 2-Chloro-2-[2-(4-Methoxyphenyl)hydrazono]acetate;(Z)-Ethyl 2-Chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;2-Chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene];I-Apixaban-2;Ukungcola kwe-Apixaban 3 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 27143-07-3 |
| I-Molecular Formula | I-C11H13ClN2O3 |
| Isisindo samangqamuzana | 256.69 g/mol |
| I-Melting Point | 94℃ |
| Ukuminyana | 1.23 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate ye-Apixaban (CAS: 503612-47-3) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Impushana Ephuzi Ekhanyayo ukuya Ephuzi | Iyahambisana |
| Ukulahlekelwa Ekumisweni | <0.50% | 0.23% |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.0% (HPLC) | 99.3% |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| 1 H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Uhlu Lwezincibilikisi Ezisetshenziswa Ekwenziweni
| Cha. | Igama | Inombolo ye-CAS. | I-Molecular Formula |
| 1 | I-Ethyl Acetate | CAS: 141-78-6 | C4H8O2 |
| 2 | I-Dichloromethane | CAS: 75-09-2 | I-CH2Cl2 |
| 3 | I-Ethyl Alcohol | CAS: 64-17-5 | C2H5OH |
5.3.1 Ukubukeka: Kufanele kube yimpushana ephuzi ngokukhanyayo ukuya kophuzi.Ngokubukeka, beka inani elanele lomkhiqizo wokuhlola (ngaphandle kokukala) endishini yekristalu ehlanzekile kungemuva elimhlophe (njengephepha elimhlophe) ngaphansi kokukhanya kwemvelo.
5.3.2 Ukuhlonza: I-1H-NMR inesakhiwo esifanayo nezinga.I-10~15mg yesampula ikalwe kushubhu kazibuthe yenuzi, futhi u-0.5mL we-deuterium DMSO yengezwa ukuze kuhlakazwe ngokugcwele isampula, yase ihlolwa ngethuluzi le-nuclear magnetic resonance elingaphezu kuka-400MHz.
5.3.3 Ukulahlekelwa lapho omiswa : Kala isampula cishe ngo-1.0g bese uyomisa amahora angu-3 kuhhavini womisa ongu-85℃.Umsebenzi othize wokubala ukwehla kwesisindo uzokwenziwa ngokuvumelana nezinhlinzeko ze-SOP-AP-QC-002-01 Zokunqunywa Kokomisa Ukuncipha Kwesisindo.
5.3.4.1 Izimo zeChromatographic:
Ama-reagents okuhlola: 1) i-acetonitrile ye-chromatography 2) amanzi ahlanzekile 3) i-phosphoric acid
Ikholomu: I-WondaCract ODS-2 4.6*250mm*5um (8520-39993)
Isigaba seselula: A: Kala ngokunembile i-1.0ml phosphoric acid kanye namanzi ayi-1000ml, isihlungi se-ultrasonic degassing.
B: I-acetonitrile.
Inqubo yegradient: ithebula elilandelayo
Isikhathi sesigaba A seselula (%) Isigaba sikamakhalekhukhwini B (%)
3 90 10
10 25 75
20 0 100
25 0 100
Umtshina: 210nm
Izinga lokushisa lekholomu: 35℃
Isivinini sokugeleza: 1.0ml/min
Usayizi wesampula: 5µl
5.3.4.2 Ukulungiswa kwesixazululo:
5.3.4.3 I-Diluent: i-acetonitrile
5.3.4.4 Isixazululo esingenalutho: i-diluent izosetshenziswa njengekhambi elingenalutho.
5.3.4.5 Isixazululo somkhiqizo wokuhlola: Kala umkhiqizo wokuhlola cishe u-12.5mg ebhodleleni levolumu engu-25ml bese ulincibilikisa nge-diluent esikalini.
5.3.4.6 Inqubo yokusebenza: Ngemva kokuthi isisekelo sethuluzi sizinzile, umjovo owodwa kuya kwemibili wesixazululo esingenalutho uyathuthukiswa, bese kuhlaziywa isisombululo somkhiqizo wokuhlola.I-chromatogram iyalondolozwa futhi ihlaziywe, kudonswa inani eliphakeme elingenalutho, futhi ukuhlanzeka okuphezulu okuphezulu kanye nemiphumela yokungcola okukodwa ku-chromatogram yomkhiqizo wokuhlola kurekhodwa ngendlela yendawo evamile.Ngemva kokuhlaziywa, i-chromatogram yanyatheliswa.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate (CAS: 27143-07-3) isetshenziswa njengendawo ephakathi ekuhlanganiseni kwe-Apixaban (CAS: 503612-47-3).I-Apixaban iwuhlobo olusha lwe-oral factor Xa inhibitor eyakhiwe ngokuhlanganyela yiBristol-Myers Squibb kanye nePfizer.Igama lokuhweba ngu-Erroto.Iwuhlobo olusha lwe-anticoagulant yomlomo.Ngokuvimbela i-coagulation factor ebalulekile Xa, i-apixaban ingavimbela ukukhiqizwa kwe-thrombin kanye ne-thrombosis.I-Apixaban yasungulwa yi-Bristal-Myers squibb Company.Ine-bioavailability enhle kanye nokukhetha okuphezulu.Yayibhalwe e-China ngo-2013. I-Apixaban iphephile, kungenzeka ukuthi ukusebenzisana kwezidakamizwa kuncane, futhi kunezindlela eziningi zokuyiqeda, okulindeleke ukuthi isetshenziswe emaqenjini akhethekile aphethwe yisifo sesibindi noma ukulimala kwezinso.
![I-Apixaban Intermediate CAS 27143-07-3 Ethyl Chloro[(4-Methoxyphenyl)hydrazono]acetate Purity ≥99.0% (HPLC)](https://www.ruifuchemical.com/uploads/Apixaban-Intermediate-CAS-490-46-0-Factory-Shanghai-Ruifu-Chemical-Co.-Ltd.-www.ruifuchem.com_-300x300.jpg)
