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I-Ibrutinib Intermediate CAS 330792-70-6 Ubumsulwa >98.0% (HPLC) Isithombe Esifakiwe
  • I-Ibrutinib Intermediate CAS 330792-70-6 Purity >98.0% (HPLC)

I-Ibrutinib Intermediate CAS 330792-70-6 Purity >98.0% (HPLC)

Incazelo emfushane:

5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile

I-CAS: 330792-70-6

Ubumsulwa: >98.0% (HPLC)

Ukubukeka: Okumhlophe Okumhlophe ukuya Kokuphuzi Okukhanyayo

I-Ibrutinib emaphakathi (CAS: 936563-96-1) 

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Izidakamizwa ze-Ibrutinib:

Ibrutinib I-CAS 936563-96-1
3-Hydroxypiperidine I-CAS 6859-99-0
I-1-Boc-3-Hydroxypiperidine I-CAS 85275-45-2
(S)-1-Boc-3-Hydroxypiperidine I-CAS 143900-44-1
I-4-Phenoxybenzoic Acid I-CAS 2215-77-2
I-4-Phenoxyphenylboronic Acid I-CAS 51067-38-0
4-Aminopyrazolo[3,4-d]pyrimidine I-CAS 2380-63-4
4-Amino-3-Iodo-1H-Pyrazolo[3,4-d]pyrimidine I-CAS 151266-23-8
Ibrutinib Deacryloylpiperidine I-CAS 330786-24-8
5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile I-CAS 330792-70-6

Chemical Properties:

Igama Lekhemikhali 5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Omqondofana Ibrutinib Intermediate N-3;3-Amino-5-(4-Phenoxyphenyl)pyrazole-4-Carbonitrile;3-Amino-4-Cyano-5-(4-Phenoxyphenyl)pyrazole;5-Amino-3-(4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile
Inombolo ye-CAS 330792-70-6
Isimo Sesitoko Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula I-C16H12N4O
Isisindo samangqamuzana 276.29
Ukuminyana 1.37±0.10 g/cm3
I-COA ne-MSDS Iyatholakala
Umsuka Shanghai, China
Ibhrendi I-Ruifu Chemical

Imininingwane:

Into Imininingwane
Ukubukeka I-Off-White to Light Yellow Powder
Ukuhlanzeka / Indlela Yokuhlaziya >98.0% (HPLC)
Ukulahlekelwa Ekumisweni <1.00%
Izinsalela Ekushiseni <0.50%
Ukungcola Okuphelele <2.00%
Izinsimbi Ezisindayo (njenge-Pb) <20ppm
1 H NMR Spectrum Ihambisana Nesakhiwo
Izinga Lokuhlola I-Enterprise Standard
Ukusetshenziswa I-Ibrutinib emaphakathi (CAS: 936563-96-1)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.

Izinzuzo:

1

I-FAQ:

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330792-70-6 - Isicelo:

I-5-Amino-3- (4-Phenoxyphenyl)-1H-Pyrazole-4-Carbonitrile (CAS: 330792-70-6) iphakathi kwe-Ibrutinib (CAS: 936563-96-1).I-Ibrutinib ibonisa umthelela wokuvimbela onamandla nongenakuhlehliswa kanye nokukhetha komsebenzi we-enzyme ye-Btk.Kulayini weseli we-DOHH2 owenziwe wasebenza we-BCR, i-Ibrutinib ivimbela i-autophosphorylation ye-Btk, i-phosphorylation ye-Btk's physiological substrate PLCγ, kanye ne-phosphorylation ye-downstream kinase eyengeziwe, i-ERK ne-IC50 ye-11 nM, 29 nM, kanye no-13 nM ngokulandelanayo.I-Ibrutinib ibonisa ukungeniswa okubalulekile okuncike kumthamo kanye nesikhathi esincike ku-cytotoxicity kumaseli we-lymphocytic leukemia (CLL) engapheli.Ngaphezu kwalokho, i-Ibrutinib idala ukufa kweseli kuye ngokuthi i-caspase pathway isebenze futhi iphikisana nekhono lamaseli e-CLL ukuze ande ngemva kokusayina kwe-TLR.

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