I-CAS 361442-04-8 Purity >99.0% (HPLC) API

Incazelo emfushane:

Amazwi afanayo: BMS-477118;Ongiza

I-CAS: 361442-04-8

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Impushana Emhlophe

I-API, Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Related Intermediate
I-CAS 361442-04-8
I-CAS 945667-22-1
(R)-1-Boc-3-Aminopiperidine CAS 188111-79-7
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
I-Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Chemical Properties:

Omqondofana	I-BMS-477118;Onglyza;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo[3.1.0]hexane-3-Carbonitrile;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxytricyclo [3.3.1.13,7]dec-1-yl)acetyl]-2-Azabicyclo[3.1.0]hexane -3-Carbonitrile
Inombolo ye-CAS	361442-04-8
Inombolo yeCAT	I-RF-PI1991
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C18H25N3O2
Isisindo samangqamuzana	315.41
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe
Iphunga	Isici
ukuhlonza	A: IR B: Isikhathi Sokugcina se-HPLC
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)
Ukucaca Kwesixazululo Samanzi	Izinto Ezisobala, Ezingenambala, Azikho Ezimisiwe
Sieve Analysis	100% Dlula i-80 Mesh
I-Melting Point	202.0~212.0℃
Ukulahlekelwa Ekumisweni	<0.50%
Umlotha one-sulphate	<0.20%
Ukuzungezisa okuqondile	+174.0°~+186.0°
Ukungcola Okukodwa	<0.50%
Ukungcola Okuphelele	<1.00%
Izinsimbi Ezisindayo	<10ppm
I-Arsenic (As)	<2.0ppm
Ukuhola (Pb)	<1.0ppm
I-Cadmium (Cd)	<1.0ppm
Izincibilikisi Ezisele	<100ppm
I-Residual Pesticide	Okubi
I-Microbiology
Inani Lepuleti Eliphelele	<1000cfu/g
Imvubelo & Isikhunta	<100cfu/g
E. Coli	Okubi
S. Aureus	Okubi
I-Salmonella	Okubi
I-Shelf Life	Izinyanga ezingama-24 Kusuka Kudethi Yokukhiqiza Uma Igcinwe Ngokufanelekile
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-API;Thayipha 2 Isifo sikashukela i-mellitus

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

(BMS-477118) (CAS: 361442-04-8) iyisivimbeli esinamandla, esikhethayo, esihlehliswayo, esiqhudelanayo futhi sisebenza ngomlomo i-dipeptidyl peptidase-4 (DPP-4) (Ki = 0.6-1.3 nM).I-BMS-477118 ine-peotential yocwaningo lwesifo sikashukela sohlobo 2.I-BMS-477118iwuhlobo lwesifo sikashukela sohlobo 2 olungashukumisa amanyikwe ukuthi akhiqize i-insulin eningi ngemva kokudla.Ifinyelelwe ngokubambisana kwe-AstraZeneca kanye ne-Bristol-Myers Squibb Company futhi ingeye-DPP-IV inhibitor.I-BMS-477118idlala indima ngokuvimbela ukuwohloka kwe-GLP-l.I-GLP-I amahomoni akhiqizwa ngokwemvelo emathunjini ngemva kokudla ukudla.Ingalawula ukukhiqizwa kwe-insulin futhi iqinise ukusetshenziswa kwe-glucose ezicutshini eziseduze.Umuthi owodwa we-BMS-477118 ungathuthukisa ukulawulwa kwe-glucose yegazi kanye nemithi ehlanganisiwe ye-BMS-477118 ene-metformin, i-Sulfonylurea ne-Thiazolidinediones ingathuthukisa umphumela wokwelapha.Kuholela engcupheni ephansi ye-hypoglycemia futhi ukusabela kwayo okubi kuyefana ne-placebo, okubonisa ukubekezelelana okungcono.NgoJulayi 31, 2009, BMS-477118 amaphilisi (Onglyza), umuthi omusha wesifo sikashukela sohlobo 2, okucwaningwe ngokuhlanganyela futhi kwathuthukiswa i-AstraZeneca kanye ne-Bristol-Myers Squibb kuvunywe yi-US FDA.Kungathathwa kanye ngosuku ukwelapha isifo sikashukela sohlobo 2 kuhlanganiswe nokulawula Ukudla kanye nokuzivocavoca.