5-(2-Pyridyl)-1,2-Dihydropyridin-2-one CAS 381233-78-9 Perampanel Intermediate Purity >98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin]-6'(1'H)-one) (I-CAS: 381233-78-9) enekhwalithi ephezulu, ephakathi kwePerampanel (CAS: 380917-97-5).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Perampanel intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 5-(2-Pyridyl) -1,2-Dihydropyridin-2-one |
| Omqondofana | [2,3'-Bipyridin]-6'(1'H) -enye;5-(Pyridin-2-yl)pyridin-2(1H)-one;5-(Pyridin-2-yl)-2(1H)-Pyridone;5-(2-Pyridyl)pyridin-2(1H)-one;I-5-Pyridin-2-yl-1H-Pyridin-2-one;5-(Pyridin-2-yl) -1,2-Dihydropyridin-2-one;I-Perampanel Ukungcola 1 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 381233-78-9 |
| I-Molecular Formula | I-C10H8N2O |
| Isisindo samangqamuzana | 172.18 g/mol |
| I-Melting Point | 71.0 ~ 75.0℃ |
| Ukuminyana | 1.221±0.06 g/cm3 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate ye-Perampanel (CAS: 380917-97-5) |
| I-Shelf Life | Izinyanga Ezingu-24 Uma Zigcinwe Ngokufanelekile |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Impushana Emhlophe Kuya Kucishe Emhlophe | Impushana Emhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | >98.0% (HPLC) | 99.7% |
| Amanzi nguKarl Fischer | <1.00% | 0.58% |
| Ukungcola Okukodwa | <1.00% | Iyahambisana |
| Ukungcola Okuphelele | <2.00% | 0.30% |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
| Isicelo | I-Intermediate ye-Perampanel (CAS: 380917-97-5) | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isitsha sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Izakhiwo: Impushana Emhlophe Ukuya Kucishe Emhlophe
Solvent: Tetrahydrofuran, Toluene, Ethylacetate, Ethanol, Methanol, tert-Butyl Methyl Ether, Petroleum Ether, n-Hexane, Dichloromethane
Hlola: Izinto Ezihlobene: Thatha lo mkhiqizo futhi uwuxube nge-diluent (amanzi esigaba seselula: i-methanol (50∶50)) ukuze wenze isixazululo esiqukethe cishe u-0.5mg nge-1ml ngayinye njengesixazululo somkhiqizo wokuhlola.Ngokokusebenza okuphezulu kwe-chromatography ye-liquid (I-Chinese Pharmacopoeia 2010 Edition II Appendix Ⅴ D), ijeli ye-silica (ZORBAX SB-C18 4.6×250mm,5m) isetshenziswe njengesigcwalisi.Isigaba seselula A kwakungamanzi, isigaba B seselula kwakuyi-methanol, kanti ubude begagasi bokutholwa babungu-254nm.Izinga lokugeleza lalingu-1.0ml/min futhi izinga lokushisa lekholomu laliyizinga lokushisa legumbi.I-5μl yesisombululo sokuhlola ikalwe ngokunembile futhi yajovwa ku-chromatograph ewuketshezi ukuze kuqoshwe i-chromatogram.Ngokwendlela yokujwayelekile yendawo, okuqukethwe kwalo mkhiqizo akukhona ngaphansi kwama-98%.Uma kuneziqongo zokungcola ku-chromatogram yesixazululo somkhiqizo wokuhlola, indawo ephakeme yokungcola ngayinye akufanele idlule u-1.0%, futhi isamba sendawo ephakeme yokungcola akufanele seqe u-2.0%.
Umswakama: Thatha lo mkhiqizo, sebenzisa isihloli somswakama, ngokwendlela ka-Karl Fischer (Chinese Pharmacopoeia 2010 edition II Isithasiselo Ⅷ M indlela yokuqala A) ukuzimisela, okuqukethwe komswakama akufanele kudlule u-1.0%.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
5-(2-Pyridyl)-1,2-Dihydropyridin-2-one ([2,3'-Bipyridin] -6'(1'H)-one) (CAS: 381233-78-9), okuphakathi I-Perampanel (CAS: 380917-97-5).IPerampanel (inikezwe ilayisense ngo-2012) iyisizukulwane sesithathu i-AED eyaziwa ngegama lobunikazi be-Fycompa® (Eisai, Hatfield) e-UK kanye ne-Banzel® (Eisai, Hatfield) e-USA.Ukwelashwa okuhambisanayo kokuquleka okugxilwe kukho noma ngaphandle kwe-generalization yesibili kanye nokuquleka okuyisisekelo okujwayelekile kwe-tonic-clonic.Ngo-Okthoba 2012, i-US FDA igunyaze i-perampanel yokwelashwa kokuquleka okuncane ezigulini ezinesifo sokuwa okungenani ezineminyaka eyi-12 ubudala.U-Perampanel ungumphikisi wokuqala wamamukeli we-AMPA ukuthola imvume ye-FDA njenge-AED.Ama-AMPA glutamate receptors atholakala ngokuyinhloko kuma-postsynaptic neurons ebuchosheni.Njengombangi okhethiwe, ongancintisani we-AMPA, i-parampanel ivimbela ukuvulwa kwesiteshi se-ion futhi yehlisa ukusabalala kwamandla esenzo.
