I-Apixaban Intermediate CAS 503615-03-0 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one Purity ≥99.0% (HPLC)
I-Ruifu Chemical ingumkhiqizi ohamba phambili we-3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 503615-03-0) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Apixaban intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 3-Morpholino-1-(4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one |
| Omqondofana | 3-(4-Morpholinyl) -1-(4-Nitrophenyl)-5,6-Dihydro-2(1H)-Pyridinone;5,6-Dihydro-3- (4-Morpholinyl) -1- (4-Nitrophenyl) -2 (1H)-Pyridinone;I-Apixaban Ephakathi 3;Ukungcola kwe-Apixaban 36;Inqubo ye-Apixaban Ukungcola 1 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 503615-03-0 |
| I-Molecular Formula | I-C15H17N3O4 |
| Isisindo samangqamuzana | 303.31 g/mol |
| I-Melting Point | 165.0 ~ 170.0℃ |
| Iphuzu elibilayo | 506.5±50.0℃ |
| Ukuminyana | 1.357g/mL |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate ye-Apixaban (CAS: 503612-47-3) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Impushana Ephuzi | Impushana Ephuzi |
| I-Melting Point | 165.0 ~ 170.0℃ | 167.0 ~ 170.0℃ |
| Ukulahlekelwa Ekumisweni | ≤0.50% | 0.3% |
| Ukungcola Komuntu Ngamunye (Ubukhulu.) | ≤0.50% | 0.3% |
| Ukungcola Okuphelele | ≤1.00% | 0.6% |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.0% (HPLC) | 99.4% |
| 1 H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| LC/MS | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe | |
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
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IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
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Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
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I-3-Morpholino-1- (4-Nitrophenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 503615-03-0) iphakathi kokuhlanganisa kwe-Apixaban (CAS: 503612-47-3) .
I-Apixaban iwuhlobo olusha lwe-oral Xa factor inhibitor eyakhiwe ngokuhlanganyela yiBristol-Myers Squibb kanye nePfizer.Igama lokuhweba i-Eratol, okuwuhlobo olusha lwe-anticoagulant yomlomo.Ngokuvimbela i-coagulation factor ebalulekile Xa, i-Apixaban ingavimbela ukukhiqizwa kwe-thrombin kanye ne-thrombosis.
Ngomhla zingama-26 kuMbasa, 2007, uBristol-Myers Squibb wahlanganyela nePfizer ukumemezela ukubambisana ekuthuthukisweni kwe-anticoagulant yomlomo entsha i-Apixaban ephethwe yiBristol-Myers Squibb njengendlela ethuthukisiwe ye-warfarin.Ngokwesivumelwano sokubambisana, i-Pfizer izokhokha inkokhelo kusengaphambili engu-US $0.25 billion kuBristol-Myers Squibb ukuze ithwale u-60% wezindleko eziphelele zokuthuthukiswa kwe-anticoagulant Apixaban (ezoqaliswa kusukela ngoJanuwari 1, 2007), kuyilapho iBristol-Myers. I-squibb izothwala u-40% osele, ngaleyo ndlela ithole ilungelo lokuthuthukisa ngokuhlanganyela nokuthengisa umuthi.
Ngo-May 2011, i-Apixaban yaba ngowokuqala ukugunyaza ukuvinjelwa kwe-venous thrombosis ezigulini ezikhulile ezenza ukuhlinzwa okukhethiwe kwe-hip noma idolo emazweni e-27 EU, e-Iceland naseNorway.
Ngomhla ka-20 Novemba 2012, i-European Commission igunyaze i-Ererto (Apixaban) yokuvimbela isifo sohlangothi kanye ne-systemic embolism ezigulini ezikhulile ezine-non-valvular atrial fibrillation (NVAF) enesici esisodwa noma ngaphezulu engozini.Kamuva, i-Canadian Food and Drug Administration, Japan, kanye ne-US FDA igunyaze i-Ererto (Apixaban) yokuvimbela isifo sohlangothi kanye ne-systemic embolism ezigulini ezikhulile ezine-non-valvular atrial fibrillation (NVAF) enesici esisodwa noma ngaphezulu engozini.
Ngo-Ephreli 12, 2013, umuthi omusha we-anticoagulant Eloto (ELIQUIS)(apixaban) owakhiwe ngokuhlanganyela yiBristol-Myers Squibb kanye noPfizer wamenyezelwa ngokusemthethweni ukuthi uzofakwa ohlwini e-China.I-Ererto iyinoveli ye-oral factor Xa inhibitor yokuvimbela i-venous thromboembolism (VTE) ezigulini ezikhulile ezithatha indawo ye-hip noma yamadolo.Ukufakwa ohlwini kunikeza ukhetho olusha oluphephile nolusebenzayo lwe-anticoagulation yomtholampilo ngemva kokuhlinzwa kwamathambo, futhi kuletha izindaba ezinhle ezigulini zaseShayina ezishintshwa ngokukhethwa kwe-hip/edolo.Ucwaningo lwezokwelapha luye lwaqinisekisa ukuthi uma kuqhathaniswa ne-40mg enoxaparin kanye ngosuku, izikhathi ezi-2 ngosuku ukuphathwa komlomo kwe-Eratol (Apixaban) i-2.5mg iphumelela kakhulu ekuvimbeleni i-venous thromboembolism ngemva kokuhlinzwa esikhundleni se-hip noma idolo, futhi ayinyusi ingozi yokopha.
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