I-Apixaban Intermediate CAS 545445-44-1 Ubumsulwa >98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 545445 -44-1) ngekhwalithi ephezulu, ephakathi kwe-Apixaban (CAS: 503612-47-3).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Apixaban Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one |
| Omqondofana | I-Apixaban Ephakathi 1;5,6-Dihydro-3- (4-Morpholinyl) -1-[4-(2-Oxo-1-Piperidinyl) phenyl] -2 (1H) -Pyridinone;5-Morpholin-4-yl-1-[4-(2-Oxopiperidin-1-yl)phenyl] -2,3-Dihydropyridin-6-one;I-Apixaban Impurity A |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 545445-44-1 |
| I-Molecular Formula | I-C20H25N3O3 |
| Isisindo samangqamuzana | 355.43 g/mol |
| I-Melting Point | >199℃(dec.) |
| Ukuminyana | 1.267 g/mL |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate ye-Apixaban (CAS: 503612-47-3) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Imininingwane | Imiphumela |
| Ukubukeka | Impushana Ephuzi Ekhanyayo | Impushana Ephuzi Ekhanyayo |
| Ukulahlekelwa Ekumisweni | <0.50% | 0.16% |
| Izinsalela ekushiseni | <0.20% | 0.07% |
| Ukuhlanzeka / Indlela Yokuhlaziya | >98.0% (Indawo ye-HPLC) | 99.12% |
| Noma yikuphi Ukungcola Komuntu Ngamunye | <0.50% | <0.50% |
| Ukungcola Okuphelele | <2.00% | 0.88% |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Kuyavumelana |
| I-LC-MS Yokuhlonza | Kuyavumelana | Kuyavumelana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
| Isicelo | I-Intermediate ye-Apixaban (CAS: 503612-47-3) | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
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Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-3-Morpholino-1-(4-(2-Oxopiperidin-1-yl)phenyl)-5,6-Dihydropyridin-2(1H)-one (CAS: 545445-44-1) iphakathi kwe-Apixaban (CAS: 503612-47-3).
I-Apixaban iwuhlobo olusha lwe-oral Xa factor inhibitor eyakhiwe ngokuhlanganyela yiBristol-Myers Squibb kanye nePfizer.Igama lokuhweba i-Eratol, okuwuhlobo olusha lwe-anticoagulant yomlomo.Ngokuvimbela i-coagulation factor ebalulekile Xa, i-Apixaban ingavimbela ukukhiqizwa kwe-thrombin kanye ne-thrombosis.Ngomhla zingama-26 kuMbasa wezi-2007, uBristol-Myers Squibb wahlanganyela nePfizer ukumemezela ukubambisana ekuthuthukisweni kwe-anticoagulant yomlomo entsha i-Apixaban ephethwe yiBristol-Myers Squibb njengendlela ethuthukisiwe ye-Warfarin.Ngo-May 2011, i-Apixaban yaba ngowokuqala ukugunyaza ukuvinjelwa kwe-venous thrombosis ezigulini ezikhulile ezenza ukuhlinzwa okukhethiwe kwe-hip noma idolo emazweni e-27 EU, e-Iceland naseNorway.Ngomhla ka-20 Novemba 2012, i-European Commission igunyaze i-Ererto (Apixaban) yokuvimbela isifo sohlangothi kanye ne-systemic embolism ezigulini ezikhulile ezine-non-valvular atrial fibrillation (NVAF) enesici esisodwa noma ngaphezulu engozini.Kamuva, i-Canadian Food and Drug Administration, Japan, kanye ne-US FDA igunyaze i-Ererto (Apixaban) yokuvimbela isifo sohlangothi kanye ne-systemic embolism ezigulini ezikhulile ezine-non-valvular atrial fibrillation (NVAF) enesici esisodwa noma ngaphezulu engozini.Ngomhla ziyi-12 kuMbasa, i-2013, umuthi omusha we-anticoagulant u-Eloto (ELIQUIS)(Apixaban) owakhiwe ngokuhlanganyela yi-Bristol-Myers Squibb kanye no-Pfizer wamenyezelwa ngokusemthethweni ukuthi uzofakwa ohlwini e-China.
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