5-Amino-3-(Trifluoromethyl)picolinonitrile CAS 573762-62-6 Apalutamide Intermediate Purity >98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-5-Amino-3-(Trifluoromethyl)picolinonitrile (CAS: 573762-62-6) enekhwalithi ephezulu, emaphakathi ye-Apalutamide (CAS: 956104-40-8).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Apalutamide Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 5-Amino-3-(Trifluoromethyl)picolinonitrile |
| Omqondofana | 5-Amino-3-(Trifluoromethyl)pyridine-2-Carbonitrile;5-Amino-3-(Trifluoromethyl)2-Cyanopyridine;5-Amino-2-Cyano-3-(Trifluoromethyl)pyridine;I-Apalutamide Ukungcola 10 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 573762-62-6 |
| I-Molecular Formula | I-C7H4F3N3 |
| Isisindo samangqamuzana | 187.12 g/mol |
| Ukuminyana | 1.45±0.10 g/cm3 |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| I-Hazard Class | 6.1 |
| Iqembu Lokupakisha | Ⅲ |
| Isigaba | I-Apalutamide emaphakathi (CAS: 956104-40-8) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Okuqinile Okuphuzi ukuya Kokuphuzi | Iyahambisana |
| Amanzi nguKarl Fischer | <0.50% | 0.35% |
| Ukuhlanzeka / Indlela Yokuhlaziya | >98.0% (HPLC) | 99.03% |
| I-Infrared Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
| Isicelo | I-Apalutamide emaphakathi (CAS: 956104-40-8) | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isitsha sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-5-Amino-3- (Trifluoromethyl) picolinonitrile (i-CAS: 573762-62-6), i-pyridine heterocyclic organic compound, engasetshenziswa njengama-intermediate emithi.I-5-Amino-3-(Trifluoromethyl) picolinonitrile iphakathi kwe-Apalutamide (CAS: 956104-40-8).I-Apalutamide iyi-antiandrogen yesizukulwane sesibili esetshenziswa ekwelapheni umdlavuza wendlala yesinye.Kungumphikisi onamandla we-androgen receptor enenani le-IC50 le-16 nM.Ibophezela ama-androgen receptors, ngaleyo ndlela ivimbele ukudluliselwa kwe-nuclear, ukubopha i-DNA nokusebenza kokubhala.I-Apalutamide inezinhlelo zokwelapha kumdlavuza we-prostate ongewona we-metastatic, omelana nokuthenwa.
I-Apalutamide isetshenziselwa ukwelapha izinhlobo ezithile zomdlavuza wendlala yesinye noma umdlavuza wendlala yesinye ongazange usabalele kwezinye izingxenye zomzimba, kodwa ongazange usizwe ngezinye izindlela zokwelapha.I-Apalutamide isekilasini lemithi ebizwa ngokuthi i-androgen receptor inhibitors.Isebenza ngokuvimbela imiphumela ye-androgen ukumisa ukukhula nokusabalala kwamangqamuzana omdlavuza.Ngomhlaka-17 Septhemba 2019, i-Food and Drug Administration igunyaze i-Apalutamide (ERLEADA, Janssen Biotech, Inc) yeziguli ezinomdlavuza wendlala yesinye we-metastatic castration-sensitive prostate (mCSPC).I-Apalutamide yaqala ukugunyazwa ngo-2018 ezigulini ezinomdlavuza we-prostate ongamelani ne-metastatic castration.
