I-TMC207 CAS 843663-66-1 Ubumsulwa >99.5% (HPLC)
Abaxhumanisi abahlobene ne-TMC207:
I-TMC207 CAS 843663-66-1
I-3-Benzyl-6-Bromo-2-Chloroquinoline CAS 654655-68-2
I-3-Benzyl-6-Bromo-2-Methoxyquinoline CAS 654655-69-3
| Igama Lekhemikhali | I-TMC207 |
| Omqondofana | I-TMC-207, R207910;Sirturo;(αS,βR) -6-Bromo-α--[2-(dimethylamino)ethyl]-2-methoxy-α-1-naphthalenyl-β-phenyl-3-Quinolineethanol;1-(6-Bromo-2-methoxyquinolin-3-yl)-4-dimethylamino-1-phenyl-2-(1-naphthyl) 2-butanol |
| Inombolo ye-CAS | 843663-66-1 |
| Inombolo yeCAT | RF2336 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C32H31BrN2O2 |
| Isisindo samangqamuzana | 555.516 |
| I-Melting Point | 104℃ |
| Ukuminyana | 1.322±0.06 g/cm3 |
| Kuyazwela | I-Hygroscopic.Izwela Ukukhanya, Izwela Umoya |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Emhlophe noma Engamhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.5% (HPLC) |
| Ukulahlekelwa Ekumisweni | <0.50% |
| Izinsalela ekushiseni | <0.20% |
| Noma yikuphi Ukungcola Komuntu Ngamunye | <0.10% |
| Isomer | <0.10% |
| Ukungcola Okuphelele | <0.50% |
| Izinsimbi Ezisindayo (njenge-Pb) | <20ppm |
| I-Arsenic (As) | <2.0ppm |
| I-Infrared Spectrum | Ivumelana Nesakhiwo |
| I-Proton NMR Spectrum | Ivumelana Nesakhiwo |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-API |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
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Izimakethe Eziyinhloko?Ithunyelwa kakhulu eNyakatho Melika, eNdiya, eRussia, eKorea, eJapan, naseYurophu, njll.
IkhwalithiIsiqiniseko?Ukuqinisekiswa kwekhwalithi okuthembekile, ukuphathwa okuqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?Nge-Express (FedEx, DHL), nge-Air, ngolwandle.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
(I-CAS: 843663-66-1), (eyaziwa ngokuthi i-TMC207 kanye ne-R207910), ethengiswa ngaphansi kwegama lokuhweba elithi Sirturo, iyinoveli ye-diarylquinoline antimycobacterial drug ethinta isifo sofuba ngokuvimbela umsebenzi we-M. tuberculosis ATP synthase proton pump.I-ATP synthesis ye-mycobacteria inemiphumela elwa namagciwane kanye ne-bactericidal.Isetshenziswa ngokomtholampilo ukwelapha isifo sofuba esingazweli ezidakamizwa eziningi (MDR-PTB).I-TMC207 inomsebenzi ofanayo wokubulala amagciwane ngokumelene nezinhlobo ezizwelayo ze-M. sofuba kanye nezinhlobo ezingazweli, futhi iphinde ibe nomthelela omuhle wokuvala inzalo kumagciwane alele.NgoZibandlela wezi-2012, i-FDA yase-US yagunyaza i-TMC207 njengengxenye yokwelapha okuhlanganisiwe kokwelashwa kwesifo sofuba esingazweli emithini eminingi (MDRTB).I-TMC207 umuthi wokuqala ogunyazwe i-MDR-TB futhi iwukugunyazwa kokuqala ovela eqenjini elisha lama-ejenti alwa nesifo sofuba eminyakeni engama-40 edlule.Ngenxa yesidingo esikhulu esingahlangatshezwanga sokwelapha i-MDR-TB, i-FDA yanikeza ukugunyazwa okusheshisiwe kwe-TMC207 okusekelwe emiphumeleni yeSigaba II, okuhlinzeka iziguli ukufinyelela emuthini ngenkathi kwenziwa izifundo zomtholampilo ezengeziwe.I-TMC207 iyi-diarylquinoline etholwe kuhlelo oluphezulu, lwesu lokuhlola iseli lonke nge-Mycobacterium smegmatis esetshenziswa njenge-surrogate ye-M. tuberculosis.I-TMC207 iyi-enantiomer eyodwa yehithi yokuhlola yokuqala.I-TMC207 inomsebenzi onamandla futhi okhethayo ngokumelene ne-mycobacteria, futhi iyasebenza ngokumelene nesifo sofuba esingezwani nomuthi kanye ne-M. esingazweli emuthini.Indlela yokusebenza ye-TMC207 ihlukile phakathi kwemithi elwa ne-TB futhi ihilela ukuvinjelwa kwe-mycobacterial ATP synthase;ayisebenzi ngokumelene ne-ATP synthase yomuntu.I-TMC207 inomsebenzi we-vivo kumamodeli amaningi angaphambi kwekliniki okutheleleka kwe-TB, iyodwa futhi ihlangene namanye ama-ejenti alwa ne-TB, futhi inomsebenzi wokubulala amagciwane kumamodeli aqinisekisiwe wokutheleleka kwe-TB.I-TMC207 ihlanganiswe ngezinyathelo ezinhlanu ukusuka ku-3-Phenylpropionic Acid kanye ne-para-Bromoaniline.Ukulandela ukwakheka kwe-amide, ukwelashwa nge-POCl3 ne-DMF ngaphansi kwezimo ze-Vilsmeier-Hack kunikeze umkhiqizo we-2-Chloroquinoline.Ukwelashwa nge-sodium methoxide, okulandelwa ukujiya nge-3-(Dimethylamino) -1-(naphthalen-1-yl) propan-1-one, kanye nokuhlukaniswa kwama-isomer kunikeza i-TMC207.
