I-Trelagliptin Succinate Intermediate CAS 865759-24-6 Ubumsulwa >98.0% (HPLC)

Incazelo emfushane:

I-Trelagliptin Succinate Intermediate-int D

I-CAS: 865759-24-6

Ubumsulwa: >98.0% (HPLC)

Ukubukeka: Okumhlophe Okumhlophe kuya Kwekristalu Ephuzi Ngokukhanyayo

Okumaphakathi kwe-Trelagliptin Succinate (CAS: 1029877-94-8) yokwelashwa kwesifo sikashukela sohlobo 2

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Izinsiza Ezihlobene Nezokuthengisa i-Trelagliptin Succinate:
I-6-Chloro-3-Methyluracil CAS 4318-56-3
I-2-Cyano-5-Flurobenzyl Bromide CAS 421552-12-7
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
I-Trelagliptin Succinate Intermediate-int D CAS 865759-24-6
I-Trelagliptin Succinate CAS 1029877-94-8
Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali	I-Trelagliptin Succinate Intermediate-int D
Omqondofana	2-((6-Chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile;2--[(6-Chloro-3,4-dihydro-3-methyl-2,4-dioxo-1(2H)-pyrimidinyl)methyl]-4-fluorobenzonitrile
Ukungcola	I-Trelagliptin Ukungcola 17
Isimo Sesitoko	Esitokweni, Isikali Sokuhweba
Inombolo ye-CAS	865759-24-6
I-Molecular Formula	I-C13H9ClFN3O2
Isisindo samangqamuzana	293.68 g/mol
Ukuminyana	1.49±0.10 g/cm3
Isikhathi Sokugcina.	Indawo Epholile Neyomile
I-COA ne-MSDS	Iyatholakala
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Izinto	Amazinga Wokuhlola	Imiphumela
Ukubukeka	I-Off-White kuya ku-Light Yellow Crystal	Kuyavumelana
Ukuhlonza
I-HPLC	Isikhathi sokugcinwa kwesampula ephezulu yokuhlolwa sithobela izinga lesithenjwa	Kuyavumelana
I-IR - I-Infrared Spectrum	I-IR Absorption spectra yesampula kanye nezinga kuyavumelana	Kuyavumelana
Ukuhlola
Ukulahlekelwa Ekumisweni	<0.50%	0.3%
Ukungcola Okuphelele	<2.00%	Kuyavumelana
Ukuhlanzeka / Indlela Yokuhlaziya	>98.0% (HPLC)	99.1%
Isiphetho	Umkhiqizo uhloliwe futhi uthobelana nezicaciso

Iphakheji/Isitoreji/Ukuthumela ngomkhumbi:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni yokugcina impahla epholile neyomile futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.Gwema ukukhanya;Akungeni moya.
Ukuthumela:Thumela emhlabeni wonke nge-FedEx / DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Izinzuzo:

Amandla Anele: Izinsiza ezanele kanye nochwepheshe

Isevisi Yobuchwepheshe: Isevisi yokuthenga yokuma eyodwa

Iphakheji le-OEM: Iphakheji yangokwezifiso kanye nelebula iyatholakala

Ukulethwa Okusheshayo: Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe

Impahla Ezinzile: Gcina isitoko esinengqondo

Ukusekelwa Kwezobuchwepheshe: Isixazululo sezobuchwepheshe siyatholakala

Isevisi Yokuhlanganisa Ngokwezifiso: Isukela kumagremu kuye kumakhilo

Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.

Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.

Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.

IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.

Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.

Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.

I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.

Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.

Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.

Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.

Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.

Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.

Isicelo:

I-2-((6-chloro-3-Methyl-2,4-dioxo-3,4-dihydropyriMidin-1(2H)-yl)Methyl)-4-fluorobenzonitrile (CAS: 865759-24-6) isetshenziswa njenge okuphakathi kwe-Trelagliptin Succinate (CAS: 1029877-94-8).I-Trelagliptin Succinate, eyakhiwe ngabakwaTakeda, eJapan, eyethulwe ngoMashi 2015, ngaphansi kwegama lezohwebo iZafatek, isetshenziselwa ukwelapha isifo sikashukela sohlobo 2.I-Trelagliptin iyi-ultra-long-acting dipeptidyl peptidase IV(DPP-4) inhibitor ngokukhetha nangokuqhubekayo ngokuvimba i-DPP-4 ukulawula amazinga kashukela egazini.I-Trelagliptin umuthi wokuqala weviki wonke we-hypoglycemic emakethe, futhi ama-DPP-4 inhibitors afanayo emakethe adinga ukuthathwa kanye ngosuku.Izinzuzo zemithi ye-Zafatek ngokungangabazeki zizohlinzeka ngezinketho zokwelashwa ezilula kakhulu ezigulini ezinesifo sikashukela.Kulindeleke ukuthi kuthuthukise kakhulu ukunethezeka nokuthobela iziguli.ngoMashi 26, 2015, umdondoshiya wemithi yaseJapan u-Takeda wamemezela ukuthi umuthi omusha wesifo sikashukela i-Zafatek ugunyazwe uMnyango Wezempilo, Wezabasebenzi Nenhlalakahle YaseJapan (MHLW) ukuze welaphe uhlobo lwesifo sikashukela sohlobo 2.Ukugunyazwa kuphawula ukuthi i-Zafatek iba umuthi wokuqala wamasonto onke we-hypoglycemic womlomo emakethe emhlabeni, futhi imele i-blockbuster ewiswe ngu-Takeda emakethe yesifo sikashukela.
I-Trelagliptin iyi-inhibitor ye-dipeptidyl peptidase IV (DPP-4) yangeviki elawula amazinga kashukela egazini ngokukhetha nangokuqhubekayo i-DPP-4.I-DPP-4 iyi-enzyme engaqalisa ukwenziwa kusebenze kwe-incretin (i-glucagon-like peptide -1 (GLP-1) kanye ne-insulinotropic polypeptide (GIP) encike ku-glucose), edlala indima ebalulekile ekulawuleni ushukela wegazi.Ukuvinjelwa kwe-DPP-4 kungakhuphula ukukhiqizwa kwe-insulin encike kushukela egazini, ngaleyo ndlela kulawule izinga likashukela egazini.Ukuhanjiswa kwe-Trelagliptin NDA kususelwa kudatha yokusebenza ngempumelelo nezokuphepha ezivela ezivivinyweni ezimbalwa zomtholampilo zesigaba III ezenziwa ezigulini zaseJapan ezinesifo sikashukela sohlobo 2.Ukusebenza kwe-Trelagliptin kuqinisekisiwe kukho konke ukuhlola, futhi inokuphepha okuhle nokubekezeleleka.Ukuphathwa kwe-Trelagliptin kanye ngesonto kungalawula ngempumelelo izinga likashukela egazini futhi kulindeleke ukuthi kuthuthukise ukuthobela imithi yeziguli.