I-Crizotinib Intermediate CAS 877399-00-3 Purity ≥98.0% (HPLC) ee ≥99.0%
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-(R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00 -3) ngekhwalithi ephezulu, ephakathi kwe-Crizotinib (CAS: 877399-52-5).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Crizotinib Intermediate,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | (R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine |
| Omqondofana | I-Crizotinib Ephakathi;Ukungcola kwe-Crizotinib Bromide;5-Bromo-3-[(1R)-1-(2,6-Dichloro-3-Fluorophenyl) ethoxy]-2-Pyridinamine;[5-Bromo-3-[(1R)-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-yl]amine |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 877399-00-3 |
| I-Molecular Formula | I-C13H10BrCl2FN2O |
| Isisindo samangqamuzana | 380.04 g/mol |
| I-Melting Point | 108.0 ukuze 113.0 ℃ |
| Ukuminyana | 1.643 |
| I-COA ne-MSDS | Iyatholakala |
| Isampula | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate of Crizotinib (CAS: 877399-52-5) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Okuphuzi Okukhanyayo Kuya Kumpushana Ophuzi kuya kuCrystal | Iyahambisana |
| I-Melting Point | 108.0 ukuze 113.0 ℃ | Iyahambisana |
| Purity (HPLC Area) | ≥98.0% | 99.1% |
| I-Enantiomeric Excess (EE) | ≥99.0% | 99.5% |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| 1 H NMR Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| Isiphetho | Lo mkhiqizo uhloliwe futhi uthobelana nezicaciso | |
| I-Shelf Life | Iminyaka emi-2 uma igcinwe kahle | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
(R)-5-Bromo-3-[1-(2,6-Dichloro-3-Fluorophenyl)ethoxy]pyridin-2-Amine (CAS: 877399-00-3) isetshenziswa njengendawo emaphakathi ye-Crizotinib (CAS: 877399-52-5).
I-Crizotinib impela iyisidakamizwa esilwa nomdlavuza esiba yi-alk (anaplastic lymphoma kinase) kanye ne-ros1 (c-ros oncogene 1) inhibitor, egunyazwe ukwelashwa kwe-non-small cell lung carcinoma (NSCLC) e-USA nakwamanye amazwe, futhi yenza izifundo eziningi ezihlola ukuphepha nokusebenza kwayo ku-anaplastic big cell lymphoma, neuroblastoma, nezinye izimila eziqinile ezithuthukile kubantu abadala nasezinganeni.
I-Crizotinib iwumuthi wokwelapha ohlosiwe womdlavuza wamaphaphu ongewona omncane owakhiwe yi-Pfizer, e-USA, i-secorri iyisidakamizwa esenza inkathi ethile yesikhathi emkhakheni wokwelashwa okuhlosiwe komdlavuza wamaphaphu.Yagunyazwa ukumakethwa e-United States ngo-Agasti 2011 futhi yabhalwa eziqondisweni zomhlaba jikelele zokwelapha umdlavuza wamaphaphu ekupheleni konyaka njengomuthi womugqa wokuqala weziguli ezine-ALK.Igunyazwe kanye ne-Crizotinib indlela yokuqala yokuxilongwa kofuzo kusetshenziswa i-fluorescence in situ hybridization (INHLANZI)-VSIs ALK Break Apart FISH Probe Kit, lena indlela esetshenziswa njengamanje ocwaningweni lomhlaba wonke lomtholampilo ukuze kutholwe izakhi zofuzo ezihlanganisiwe ze-EML4-ALK ku-NSCLC.Lokhu kuhlolwa kuzosiza ukukhomba iziguli ezingase zizuze ekwelashweni kwe-Crizotinib.
I-Crizotinib iyi-inhibitor ekhethiwe ye-tyrosine kinase receptor esetshenziswa ekwelapheni amacala akhethiwe omdlavuza wamaphaphu ongewona omncane omncane.Kuyi-ATP embaxambili yokuncintisana inhibitor ye-tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) kanye ne-ALK (cellular IC50=20 nM), kokubili okuyizinjongo ezibalulekile zokwelashwa ngamakhemikhali omdlavuza.Lapho i-Crizotinib ihlolelwa ukukhetha uma iqhathaniswa namanye ama-kinases kwatholakala ukuthi ine-enzyme IC50 phakathi kokuphindaphinda okungu-100 kwe-c-MET kwe-13 ye-120 kinases ehloliwe.Ezivivinyweni zamaselula, i-Crizotinib itholakale ivimbela i-RON (i-recepteur d'origine nantais) kinase ngewindi lokukhetha eliphindwe izikhathi ezingu-10 ngaphezu kwe-c-MET.Sekukonke, le agent ivimbela ukukhula kwamangqamuzana e-tumor.I-XALKORI®(Crizotinib) umuthi kadokotela osetshenziswa ukwelapha abantu abanomdlavuza wamaphaphu ongewona omncane (i-NSCLC) osusabalele kwezinye izingxenye zomzimba futhi obangelwa ukukhubazeka noma ohlotsheni olubizwa ngokuthi i-ALK (anaplastic lymphoma kinase) noma isakhi sofuzo esibizwa nge-ROS1.Akwaziwa ukuthi i-XALKORI iphephile futhi isebenza ngempumelelo yini ezinganeni.
