I-1-Boc-4-(4-Bromopyrazol-1-yl)piperidine CAS 877399-50-3 Purity ≥98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) enekhwalithi ephezulu, emaphakathi ye-Crizotinib (CAS: 877399- 52-5).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-1-Boc-4-(4-Bromopyrazol-1-yl) i-piperidine |
| Omqondofana | I-Crizotinib-D;i-tert-Butyl 4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylate;4-(4-Bromopyrazol-1-yl)piperidine-1-Carboxylic Acid tert-Butyl Ester;I-1-tert-Butoxycarbonyl-4-(4-Bromopyrazol-1-yl)piperidine;1-(4-Boc-Piperidino)-4-Bromopyrazole;1-Boc-4-(4-Bromo-1-Pyrazolyl)piperidine;I-4-Bromo-1-(N-Boc-Piperidin-4-yl)-1H-Pyrazole;i-tert-butyl 4-(4-Bromo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;1-(4-Boc-1-Piperidinyl)-4-Bromopyrazole;I-Crizotinib Ukungcola 4 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 877399-50-3 |
| I-Molecular Formula | I-C13H20BrN3O2 |
| Isisindo samangqamuzana | 330.23 g/mol |
| I-Melting Point | 77.0 ukuze 81.0℃ |
| Ukuminyana | 1.43 |
| Ukuncibilika | I-Soluble ku-Methanol |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate of Crizotinib (CAS: 877399-52-5) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Okuqinile Okumhlophe | Okuqinile Okumhlophe |
| I-Melting Point | 77.0 ukuze 81.0℃ | Iyahambisana |
| Amanzi nguKarl Fischer | <0.50% | 0.11% |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥98.0% (HPLC) | 99.3% |
| 1H NMR Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| IMisa | Ivumelana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
Izimpawu Zengozi Xn - Ziyingozi
Amakhodi Engozi 22 - Ayingozi uma uwagwinyile
I-1-Boc-4-(4-Bromopyrazol-1-yl)piperidine (CAS: 877399-50-3) isetshenziswa njengendawo ephakathi ye-Crizotinib (CAS: 877399-52-5).I-Crizotinib (igama lokuhweba i-Xalkori,) iyisidakamizwa esilwa nomdlavuza esisebenza njenge-ALK (anaplastic lymphoma kinase) kanye ne-ROS1 (c-ros oncogene 1) inhibitor, egunyazwe ukwelashwa kwe-non-small cell lung carcinoma (NSCLC) e-US. kanye namanye amazwe, futhi kuhlolwa ukuphepha nokusebenza ngempumelelo kwayo inanaplastic cell lymphoma enkulu, i-neuroblastoma, nezinye izimila eziqinile ezithuthukile kokubili abadala nasezinganeni.
Ngo-Agasti 2011, i-United States FDA igunyaze i-Crizotinib (PF- 02341066) yokwelashwa kwe-anaplastic lymphoma kinase (ALK) ehlele kabusha umdlavuza wamaphaphu ongewona wamaseli amancane (NSCLC).I-Crizotinib iyi-dual ATP inhibitor yokuncintisana ye-tyrosine kinases c-MET (Mesenchymal-Epithelial Transition Factor) kinase (cellular IC50=8 nM) kanye ne-ALK (cellular IC50=20 nM), kokubili okuyizinjongo ezibalulekile zokwelashwa ngamakhemikhali omdlavuza.Lapho i-Crizotinib ihlolelwa ukukhetha uma iqhathaniswa namanye ama-kinases kwatholakala ukuthi ine-enzyme IC50 phakathi kokuphindaphinda okungu-100 kwe-c-MET kwe-13 ye-120 kinases ehloliwe.Ezivivinyweni zamaselula, i-Crizotinib itholakale ivimbela i-RON (i-recepteur d'origine nantais) kinase ngewindi lokukhetha eliphindwe izikhathi ezingu-10 ngaphezu kwe-c-MET.
