1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole CAS 877399-73-0 Purity ≥99.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo we-1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) enekhwalithi ephezulu, emaphakathi ye-Crizotinib (CAS: 877399-52 -5).I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Crizotinib Intermediates,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole |
| Omqondofana | 1-Boc-4-(4-Iodo-1H-Pyrazol-1-yl)piperidine;i-tert-Butyl 4-(4-Iodo-1H-Pyrazol-1-yl)piperidine-1-Carboxylate;i-tert-Butyl 4-(4-Iodopyrazolyl)piperidinecarboxylate;I-Crizotinib Ukungcola 16 |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 877399-73-0 |
| I-Molecular Formula | I-C13H20IN3O2 |
| Isisindo samangqamuzana | 377.22 g/mol |
| I-Melting Point | 97℃ |
| Ukuminyana | 1.60±0.10 g/cm3 |
| Kuyazwela | Ukukhanya Okuzwelayo |
| Isikhathi Sokugcina. | 2~8℃, Vikela Ekukhanyeni |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Isigaba | I-Intermediate of Crizotinib (CAS: 877399-52-5) |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Okuqinile Okumhlophe Kuya Kuphuzi Okukhanyayo | Okuqinile Okumhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.0% (HPLC) | 99.58% |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| 1 H NMR Spectrum | Ivumelana Nesakhiwo | Iyahambisana |
| ESI+ | Kuyavumelana | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe | |
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-1-(1-Boc-4-Piperidinyl)-4-Iodopyrazole (CAS: 877399-73-0) enekhwalithi ephezulu, ephakathi kwe-Crizotinib (CAS: 877399-52-5).I-Crizotinib iwumuthi wokwelapha ohlosiwe womdlavuza wamaphaphu ongewona omncane owakhiwe yi-Pfizer, e-USA, i-secorri iyisidakamizwa esenza inkathi ethile yesikhathi emkhakheni wokwelashwa okuhlosiwe komdlavuza wamaphaphu.Yagunyazwa ukumakethwa e-United States ngo-Agasti 2011 futhi yabhalwa eziqondisweni zomhlaba jikelele zokwelapha umdlavuza wamaphaphu ekupheleni konyaka njengomuthi womugqa wokuqala weziguli ezine-ALK.Igunyazwe kanye ne-Crizotinib indlela yokuqala yokuxilongwa kofuzo kusetshenziswa i-fluorescence in situ hybridization (INHLANZI)-VSIs ALK Break Apart FISH Probe Kit, lena indlela esetshenziswa njengamanje ocwaningweni lomhlaba wonke lomtholampilo ukuze kutholwe izakhi zofuzo ezihlanganisiwe ze-EML4-ALK ku-NSCLC.Lokhu kuhlolwa kuzosiza ukukhomba iziguli ezingase zizuze ekwelashweni kwe-Crizotinib.ku-25, lona umuthi wokuqala ozosetshenziswa ekwelapheni iziguli ezinomdlavuza wamaphaphu osezingeni eliphezulu noma we-metastatic non-small cell lung (NSCLC) oyi-anaplastic lymphoma kinase (ALK) -positive njengoba kunqunywe ukuhlolwa okugunyazwe yi-SFDA.
I-Crizotinib (PF-02341066) I-Crizotinib iyi-c-Met enamandla ne-ALK inhibitor, amanani e-IC50 ku-cell assay ayengu-11 nM kanye no-24 nM, ngokulandelanayo.Futhi iyi-inhibitor enamandla ye-ROS1 enenani le-Ki elingaphansi kuka-0.025 nM.I-Crizotinib ingenza i-autophagy emigqeni yamaseli omdlavuza wamaphaphu ehlukahlukene ngokuvimbela indlela ye-STAT3.
