I-CAS 945667-22-1 Purity >99.0% (HPLC) API

Incazelo emfushane:

I-CAS: 945667-22-1

Ubumsulwa: >99.0% (HPLC)

Ukubukeka: Impushana Emhlophe

I-API, Ikhwalithi Ephezulu, Ukukhiqizwa Kwezohwebo

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Ruifu Chemical Supply Related Intermediate
I-CAS 361442-04-8
I-CAS 945667-22-1
(R)-1-Boc-3-Aminopiperidine CAS 188111-79-7
(R)-(-)-3-Aminopiperidine Dihydrochloride CAS 334618-23-4
I-Boc-3-Hydroxy-1-Adamantyl-D-Glycine CAS 361442-00-4
(1S,3S,5S)-3-(Aminocarbonyl)-2-Azabicyclo [3.1.0]hexane-2-Carboxylic Acid tert-Butyl Ester CAS 361440-67-7
2-(3-Hydroxy-1-Adamantyl)-2-Oxoacetic Acid CAS 709031-28-7

Chemical Properties:

Omqondofana	I-BMS-477118 Hydrate;I-Onglyza Hydrate;(1S,3S,5S)-2-[(2S)-2-Amino-2-(3-Hydroxy-1-Adamantyl)acetyl]-2-Azabicyclo [3.1.0]hexane-3-Carbonitrile Hydrate;(1S,3S,5S)-2-[(S)-2-Amino-2-[(1r,3R,5R,7S)-3-Hydroxyadamantan-1-yl]acetyl]-2-Azabicyclo [3.1.0 ]hexane-3-Carbonitrile Hydrate
Inombolo ye-CAS	945667-22-1
Inombolo yeCAT	I-RF-PI1992
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	C18H25N3O2·H2O
Isisindo samangqamuzana	333.43
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Emhlophe
ukuhlonza	A: IR B: Isikhathi Sokugcina se-HPLC
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC, On Dried Basis)
Okuqukethwe kwamanzi (KF)	5.3%~7.3%
Izinsalela ekushiseni	<0.20%
Ukungcola Okukodwa	<0.50%
Ukungcola Okuphelele	<1.00%
Izinsimbi Ezisindayo	<10ppm
I-Arsenic (As)	<2ppm
I-Microbiology
Inani Lepuleti Eliphelele	<1000cfu/g
Imvubelo & Isikhunta	<100cfu/g
E. Coli	Okubi
S. Aureus	Okubi
I-Salmonella	Okubi
I-Shelf Life	Izinyanga ezingama-24
Izinga Lokuhlola	I-Enterprise Standard
Ukusetshenziswa	I-API;Isetshenziselwa Ukwelapha Isifo sikashukela sohlobo II

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama

Izinzuzo:

I-FAQ:

Isicelo:

I-API (i-CAS: 945667-22-1) iyi-inhibitor ye-dipeptidyl peptidase-4 (DPP4) ekhethiwe futhi ehlehliswayo engase isetshenziselwe ukuthuthukisa ukwelashwa kwesifo sikashukela sohlobo 2.Kuyi-inhibitor ye-DPP4 ekhethwayo neshintshekayo ene-IC50 engu-26 nM kanye ne-Ki yevelu engu-1.3 nM.IC50: 26 nM.Ithagethi: I-DPP4 in vitro: Ine-Ki ye-inhibition engaguquki engu-1.3 nM ye-DPP4 inhibition, enamandla ngokuphindwe ka-10 kune-Sitagliptin (amanye ama-DPP4 inhibitor amabili) ane-Ki of 13 kanye ne-18 nM.Ngaphezu kwalokho, Ibonisa ukucaciswa okukhulu kwe-DPP4 kunama-enzyme e-DPP8 noma i-DPP9 (400- kanye ne-75- fold, ngokulandelana).I-metablite yayo esebenzayo inamandla aphindwe kabili kunomzali.Kokubili (i-CAS: 945667-22-1) kanye ne-metabolite yayo ikhetha kakhulu (>4000-fold) yokuvimbela i-DPP4 uma kuqhathaniswa nohlu lwamanye ama-protease.(I-CAS: 945667-22-1) inciphisa ukuwohloka kwe-incretin hormone glucagon-like peptide-1, ngaleyo ndlela ithuthukise izenzo zayo, futhi ihlotshaniswe nokusebenza okuthuthukisiwe kwe-β-cell kanye nokucindezelwa kwe-glucagon secretion.in vivo: Isebenza kahle kakhulu ekutholeni izithuthukisi ezimakiwe ezincike kumthamo ekukhishweni kwe-glucose ebangeni lethamo elingu-0.13-1.3 mg/kg kumagundane e-ob/ob ahlobene nezilawuli.