I-4-Chloro-6-Iodoquinazoline CAS 98556-31-1 Ubumsulwa >98.0% (HPLC)
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-4-Chloro-6-Iodoquinazoline (CAS: 98556-31-1) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-4-Chloro-6-Iodoquinazoline,Please contact: alvin@ruifuchem.com
Igama Lekhemikhali | 4-Chloro-6-Iodoquinazoline |
Omqondofana | 6-Iodo-4-Chloroquinazoline |
Isimo Sesitoko | Ku-Stock, Commercial Production |
Inombolo ye-CAS | 98556-31-1 |
I-Molecular Formula | I-C8H4ClIN2 |
Isisindo samangqamuzana | 290.49 g/mol |
I-Melting Point | 175.0 ukuze 179.0 ℃ |
Ukuminyana | 2.017±0.06 g/cm3 |
I-Refractive Index n20/D | 1.739 |
Kuyazwela | Kuyazwela emoyeni |
I-COA ne-MSDS | Iyatholakala |
Umsuka | Shanghai, China |
Ibhrendi | I-Ruifu Chemical |
Izinto | Amazinga Wokuhlola | Imiphumela |
Ukubukeka | Umhlaba Ophuzi Ukuya Kokuphuzi Okunsundu | Umhlaba Ophuzi Oyimpushana |
I-Melting Point | 175.0 ukuze 179.0 ℃ | 177.2℃ |
Ukulahlekelwa Ekumisweni | <1.00% | 0.15% |
Ukuhlanzeka / Indlela Yokuhlaziya | >98.0% (HPLC) | 98.43% |
1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
Isicelo | Iphakathi kweLapatinib / Lapatinib Ditosylate Monohydrate |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isitsha sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-4-Chloro-6-Iodoquinazoline (i-CAS: 98556-31-1) iphakathi ekuhlanganiseni kwe-Lapatinib (CAS: 231277-92-2) / Lapatinib Ditosylate Monohydrate (CAS: 388082-78-8).
I-Lapatinib isidakamizwa esisha esihloselwe ukwelapha umdlavuza webele esakhiwe futhi sakhiqizwa yi-GlaxoSmithKline, esigunyazwe yi-US Food and Drug Administration ngo-March 13, 2007. Inkomba evunyelwe okwamanje ihlanganiswe ne-capecitabine yomdlavuza webele othuthukile noma we-metastatic, kanye neziguli zomdlavuza webele. kumele zelashwe ngeminye imithi yomugqa wokuqala.Igama layo lokuhweba e-United States yiTykerb.Ngomhla ziyi-14 kuZibandlela wezi-2007, i-European Medicines Agency (EMEA) yagunyaza ukufakwa kuhlu kweLapatinib eYurophu ngaphansi kwegama lokuhweba elithi Tyverb.Ukwelashwa okuhloswe ngamangqamuzana omdlavuza webele kubhekisela ekwelapheni ama-oncogenes kanye nemikhiqizo yokukhuluma ehlobene ehlobene nokuvela nokukhula komdlavuza webele.Izidakamizwa eziqondiswe kumamolekyuli zivimbela noma zibulale amaseli wesimila ngokuvimbela ukudluliselwa kwesignali kumaseli wesimila noma amaseli ahlobene ukuze alawule izinguquko ekukhulumeni kofuzo lweseli.I-Lapatinib iyi-molecule yomlomo encane ye-epidermal growth factor tyrosine kinase inhibitor.Ukuhlolwa komtholampilo kubonise ukuthi ezigulini zomdlavuza webele we-HER2 eziye zaqala ukumelana ne-Roche's Herceptin (Herceptin), i-Lapatinib inomphumela omuhle womtholampilo.Ukuhlolwa kwe-in vitro, i-Lapatinib ibe nomthelela omkhulu wokuvimbela ukukhula emigqeni yamaseli omdlavuza webele we-Her-2.Ezivivinyweni zeSigaba I zomdlavuza webele othuthukisiwe one-Her-2 overexpression, i-Lapatinib nayo inezinga eliphezulu elisebenzayo futhi ayinakho ukumelana ne-Herceptin (trastuzumab).Ngenxa yokuthi ukwakheka kwayo kuyi-molecule encane, ngokungafani ne-Herceptin (trastuzumab), ingangena kumgoqo wegazi nobuchopho futhi ibe nomthelela othile wokwelapha kumetastasis yobuchopho yomdlavuza webele.
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