I-Celecoxib CAS 169590-42-5 Assay 98.0~102.0%
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-Celecoxib (CAS: 169590-42-5) enekhwalithi ephezulu.I-Ruifu Chemical inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-Celecoxib,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-Celecoxib |
| Omqondofana | Celebrex;Celebra;Celecox;I-Onsenal;Solexa;SC-58635;I-SC 58635;I-YM-177;4--[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]benzenesulfonamide;5-(4-Methylphenyl)-1-(4-Sulfamoylphenyl)-3-(Trifluoromethyl)pyrazole |
| Isimo Sesitoko | Ku-Stock, Commercial Production |
| Inombolo ye-CAS | 169590-42-5 |
| I-Molecular Formula | I-C17H14F3N3O2S |
| Isisindo samangqamuzana | 381.37 g/mol |
| I-Melting Point | 160.0 ukuze 165.0 ℃ |
| Ukuminyana | 1.43±0.10 g/cm3 |
| Ukuncibilika kwamanzi | Ayincibiliki Emanzini |
| Ukuncibilika | I-Soluble Kakhulu ku-Methanol;Incibilika ku-Ethanol |
| I-COA ne-MSDS | Iyatholakala |
| Isampula | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | I-Crystalline Powder Emhlophe noma Cishe Emhlophe | Iyahambisana |
| Isivivinyo | 98.0~102.0% | 99.8% |
| I-Melting Point | 160.0 ukuze 165.0 ℃ | 162.2℃ |
| Amanzi nguKarl Fischer | <0.50% | 0.11% |
| Izinsalela ekushiseni | <0.20% | 0.05% |
| Izinsimbi Ezisindayo (Pb) | ≤20ppm | <10ppm |
| I-Celecoxib Related Compound A | <0.40% | <0.20% |
| I-Celecoxib Ehlobene Nenhlanganisela B | <0.10% | <0.10% |
| Ukungcola Okungacacisiwe Ngamunye | <0.10% | <0.10% |
| Ukungcola okuphelele | <0.50% | 0.20% |
| I-Infrared Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| 1H NMR Spectrum | Ihambisana Nesakhiwo | Iyahambisana |
| Isiphetho | Umkhiqizo uhloliwe futhi uthobela imininingwane enikeziwe | |
Iphakheji:Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina isiqukathi sivalwe ngokuqinile futhi usigcine endaweni epholile, eyomile (2~8℃) nengena umoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
I-Celecoxib
I-C17H14F3N3O2S 381.4
4--[5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide;
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide [169590-42-5]
INCAZELO
I-Celecoxib iqukethe i-NLT 98.0% kanye ne-NMT 102.0% ye-C17H14F3N3O2S, ibalwe ngesisekelo se-anhydrous
UKUKHOMBA
• A. UKUMNXA OKUNOLWAZI LWE-INFRARED <197>: [INOTHI-Izindlela <197A>, <197K>, noma <197M> ngaphansi kwe-Infrared Absorption zingasetshenziswa.]
[QAPHELA-Uma i-spectra etholiwe sibonisa umehluko, ncibilikisa into ezohlolwa kanye Nezinga Lereferensi ngokuhlukene ku-isopropyl alcohol, uhwamuke uze wome, futhi urekhode i-spectra entsha.]
• B. Isikhathi sokugcina sesiqongo esikhulu sesixazululo Sesampuli sihambisana naleso Sesixazululo Esijwayelekile, njengoba sitholwe ku-Assay.
ISIVIVINYO
• INQUBO
Isigcinalwazi: 2.7 g/L we-monobasic potassium phosphate elungiswe ne-phosphoric acid ukuze ibe i-pH engu-3.0 ± 0.2
Isigaba seselula: I-Methanol, i-acetonitrile, ne-Buffer (3:1:6)
I-Diluent: I-Methanol namanzi (3:1)
Isixazululo sokufaneleka kwesistimu: 0.5 mg/mL ye-USP
I-Celecoxib RS kanye no-2.4 µg/mL ngayinye ye-USP Celecoxib Related Compound A RS kanye ne-USP Celecoxib Related Compound B RS ku-Diluent
Isixazululo esijwayelekile: 0.5 mg/mL ye-USP Celecoxib RS ku-Diluent
Isixazululo sesampula: 0.5 mg/mL ye-Celecoxib ku-Diluent
Isistimu yeChromatographic
(Bona i-Chromatography <621>, Ukufaneleka Kwesistimu.)
Imodi: LC
Umtshina: UV 215 nm
Ikholomu: 4.6-mm × 25-cm;5-µm ukupakisha L11
Izinga lokushisa lekholomu: 60°
Izinga lokugeleza: 1.5 mL/min
Usayizi womjovo: 25 µL
Isikhathi sokugijima: Cishe izikhathi ezingu-1.5 ze-celecoxib peak elution
Ukufaneleka kwesistimu
Amasampula: Isixazululo sokufaneleka kwesistimu nesixazululo Esijwayelekile
Izidingo zokufaneleka
Isixazululo: I-NLT 1.8 phakathi kwenhlanganisela ehlobene ne-celecoxib A ne-Celecoxib kanye ne-NLT 1.8 phakathi kwe-Celecoxib ne-Celecoxib ehlobene nenhlanganisela B, Isixazululo sokufaneleka kwesistimu
Ukuchezuka okujwayelekile okuhlobene: I-NMT 0.73%, Isixazululo esijwayelekile
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti le-C17H14F3N3O2S engxenyeni ye-Celecoxib ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × 100
rU = impendulo ephezulu evela kusixazululo Sesampula
rS = impendulo ephezulu evela kusixazululo Esijwayelekile
CS = ukugxila kwesixazululo Esijwayelekile(mg/mL)
I-CU = ukugxila kwesixazululo sesampula (mg/mL)
Imibandela yokwamukela: 98.0%~102.0% kusisekelo se-anhydrous
UKUNGCOLA
Ukungcola Okungaphili
• IZIMTHETHO EZISINDAYO: NMT 20 ppm
I-Diluent: I-acetone namanzi (17:3)
Isixazululo esijwayelekile: Nciphisa u-1.0 mL Wesixazululo Esijwayelekile Sokuhola, esilungiselelwe njengoba kuqondiswe ngaphansi kwe-Heavy Metals <231>, Ama-Special Reagents, nge-Diluent kuya ku-20 mL.
Isixazululo esiyisampula: Chaza u-0.50 g we-Celecoxib ku-20mL we-Diluent.
Isixazululo esingenalutho: 20 mL we-Diluent
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile, Isixazululo esingenalutho, kanye nesixazululo esiyisampula
Esixazululo ngasinye, engeza u-2 mL we-pH 3.5 Acetate Buffer elungiselelwe njengoba kuqondiswe ngaphansi kwe-Heavy Metals <231>, Indlela I. Xuba, bese wengeza kusixazululo ngasinye u-1.2 mL we-thioacetamide–glycerin base TS.Hlanganisa ngokushesha, futhi uvumele ukuma imizuzu emi-2.Dlulisa izixazululo ngesihlungi sikasayizi wembotshana ongu-0.45-µm.Qhathanisa amabala ezihlungi ezitholakala kusixazululo ngasinye.
Imibandela yokwamukela: Umbala onsundu ngokumnyama wendawo ophuma kusixazululo Sesampuli awuqini kakhulu kunalowo webala eliwumphumela wesixazululo Esivamile.Ukuhlola akuvumelekile uma isixazululo Esijwayelekile singabonisi umbala onsundu ngokumnyama uma kuqhathaniswa nesixazululo Esingenalutho.
• INSASA EKUSHIYENI <281>: I-NMT 0.2%, kusetshenziswa i-platinum crucible
Ukungcola Okuphilayo
• INQUBO
I-Buffer, isigaba seselula, i-Diluent, isixazululo sokufaneleka kwesistimu, isixazululo sesampuli, kanye nesistimu ye-Chromatographic: Qhubeka njengoba uqondiswe ku-Assay.
Isixazululo esijwayelekile: 0.5 µg/mL ye-USP Celecoxib RS ku-Diluent
Ukufaneleka kwesistimu
Amasampula: Isixazululo sokufaneleka kwesistimu nesixazululo Esijwayelekile
Izidingo zokufaneleka
Isixazululo: I-NLT 1.8 phakathi kwenhlanganisela ehlobene ne-Celecoxib A ne-Celecoxib kanye ne-NLT 1.8 phakathi kwe-Celecoxib ne-Celecoxib ehlobene nenhlanganisela B, Isixazululo sokufaneleka kwesistimu
Isilinganiso somsindo wesignali: NLT 20, Isixazululo esijwayelekile
Ukuhlaziya
Amasampula: Isixazululo esijwayelekile kanye nesixazululo esiyisampula
Bala iphesenti lokungcola ngakunye engxenyeni ye-Celecoxib ethathiwe:
Umphumela = (rU/rS) × (CS/CU) × 100
i-rU = impendulo ephezulu yokungcola ngakunye kusixazululo Sesampuli
rS = impendulo ephezulu ye-celecoxib kusixazululo Esijwayelekile
CS = ukugcwala kwe-celecoxib kusixazululo Esijwayelekile (mg/mL)
CU = ukugcwala kwe-Celecoxib kusixazululo Sesampula (mg/mL)
Imibandela yokwamukela
Ukungcola komuntu ngamunye: Bheka Ithebula 1.
[QAPHELA-Unganaki noma yikuphi ukungcola okuphakeme okungaphansi kuka-0.05%.]
Ithebula 1
| Igama | Isikhathi Sokugcina Esihlobene | Umbandela Wokwamukela i-NMT (%) |
| Inhlanganisela ehlobene ne-Celecoxib Aa | 0.9 | 0.4 |
| I-Celecoxib | 1.0 | - |
| I-Celecoxib ehlobene ne-compound Bb | 1.1 | 0.10 |
| Ukungcola komuntu ngamunye okungacacisiwe | - | 0.10 |
| Ukungcola okuphelele | - | 0.5 |
i-4--[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
b 4-[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
IZIVIVINYO EZITHILE
• UKUNIKEZWA KWAMANZI, Indlela I <921>: I-NMT 0.5%, kusetshenziswa isampula engu-400-mg
IZIDINGO EZENGEZIWE
• UKUPAKASHA KANYE NESIGCINI: Londoloza ezitsheni eziqinile, ezivikelekile ekukhanyeni nasemanzini.Gcina ekamelweni lokushisa
• AMAZINGA EREferensi e-USP <11>
USP Celecoxib RS
p-[5-p-Tolyl-3-(trifluoromethyl)pyrazol-1-yl]benzenesulfonamide
I-C17H14F3N3O2S 381.4
I-USP Celecoxib Inhlanganisela Ehlobene A RS
4--[5-(3-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
I-C17H14F3N3O2S 381.4
I-USP Celecoxib Inhlanganisela Ehlobene B RS
4--[3-(4-Methylphenyl)-5-(trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide.
I-C17H14F3N3O2S 381.4
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
| Izimpawu Eziyingozi | I-Xn - Iyingozi |
| Amakhodi Engozi | R20/21/22 - Kuyingozi ngokuhogela, ukuthintana nesikhumba futhi uma ukugwinyile. |
| R52 - Iyingozi ezintweni eziphila emanzini | |
| I-R61 - Ingabangela ukulimala enganeni engakazalwa | |
| R60 - Ingase iphazamise inzalo | |
| Incazelo Yokuphepha | S22 - Ungaphefumuli uthuli. |
| I-S24/25 - Gwema ukuthintana nesikhumba namehlo. | |
| I-S28 - Ngemva kokuthinta isikhumba, geza ngokushesha ngensipho eningi. | |
| I-S37/39 - Gqoka amagilavu afanelekile kanye nokuvikela iso/ubuso | |
| Ama-ID e-UN | UN 3077 9 / PGIII |
| I-WGK Germany | 3 |
| I-RTECS | DB2944937 |
| Ikhodi ye-HS | 2935900090 |
| I-Hazard Class | I-IRRITANT |
I-Celecoxib ne-Rofecoxib zingama-COX-2 inhibitors amabili asetshenziswayo njengamanje.Ithuthukiswe ngempumelelo yi-GD Searle & Pfizer Co. (US,) ekhishwe ngo-1999, igama lokuhweba: Celebrex.I-Celecoxib iyi-nonsteroidal, i-ejenti elwa nokuvuvukala enemiphumela ephawulekayo ye-analgesic kanye ne-anti-inflammatory, ebangela izehlakalo eziphansi kakhulu zezilonda eziphezulu ze-gastrointestinal kanye nezinye izinkinga.Isetshenziswa ngokomtholampilo ukwelapha i-osteoarthritis eyingozi futhi engapheli kanye ne-rheumatoid arthritis, enendima elwa nokuvuvukala, ekhulula izimpawu nezimpawu ze-osteoarthritis kanye nesifo samathambo.
I-Celecoxib (CAS: 169590-42-5), Yokusiza kanye nokuphathwa kwe-osteoarthritis (OA), isifo samathambo (RA), isifo samathambo sezingane (JRA), i-ankylosing spondylitis, ubuhlungu obukhulu, i-dysmenorrhea eyinhloko kanye ne-oral adjunct ekunakekelweni okujwayelekile kweziguli. nge-familia adenomatous polyposis.
I-Celecoxib (i-CAS: 169590-42-5) inomphumela wokulwa nokuvuvukala kanye ne-analgesic wama-NSAID.Ngenxa yesakhiwo sayo samakhemikhali, ingahlanganiswa ne-COX-2, ivimbela ngokukhetha i-COX-2.Iqembu layo le-phenyl libopha nesiteshi se-hydrophobic se-COX-2, futhi i-hydrophilic sulfonamide yayo yakha iketango le-hydrogen eline-513 arginine kanye ne-90 histidine "ephaketheni elingaseceleni le-COX-2."Iphinde isondelene ne-arginine esesimweni se-COX-2120 futhi ibamba iqhaza ekuvimbeleni i-COX-2 ekuguquleni i-arachidonic acid ibe yi-prostaglandin eyingozi emzimbeni womuntu.Ngenxa yomehluko ocashile phakathi kwezakhiwo ze-COX-1 ne-COX -2, i-Celecoxib ayikwazi ukungena ku-molecule ye-COX-1, noma ivimbele ukuguqulwa kwayo kwe-arachidonic acid ibe yi-prostaglandin. izinkinga zokucasuka kwesisu zama-NSAID asetshenziswa kakhulu.
I-Celecoxib (i-CAS: i-169590-42-5) iboniswa ukwelashwa kwe-osteoarthritis kanye ne-rheumatoid arthritis.Ukusetshenziswa kwayo kuvinjelwe kubantu abane-hypersensitivity ku-sulfonamides noma amanye ama-NSAID.Kufanele isetshenziswe ngokuqapha kubantu abanesifo se-hepatic.Ukusebenzelana kwenzeka nezinye izidakamizwa ezidala i-CYP2C9 (isb i-rifampin rifampin) noma ziqhudelane ngemetabolism ngale enzyme (isb. i-fluconazole, i-leflunomide).Ukusabela okungekuhle okuvame kakhulu ku-celecoxib imiphumela ye-GI ethambile kuya kwemaphakathi efana ne-dyspepsia, isifo sohudo, nobuhlungu besisu.I-GI eyingozi kanye nemiphumela ye-renal yenzekile kuyaqabukela.
