I-Chloramphenicol CAS 56-75-7 Purity ≥99.0% (HPLC) Ukuhlanzeka Okuphezulu
Umkhiqizi Ohlinzeka Ngokuhlanzeka Okuphezulu Nokukhiqiza Kwezentengiso
(1R,2R)-(-)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 716-61-0
(1S,2S)-(+)-2-Amino-1-(4-nitrophenyl)-1,3-propanediol CAS 2964-48-9
I-Chloramphenicol CAS 56-75-7
| Igama Lekhemikhali | I-Chloramphenicol |
| Omqondofana | I-D-(-)-threo-2-Dichloroacetamido-1-(4-nitrophenyl) -1,3-propanediol;2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)-2-propyl]acetamide |
| Inombolo ye-CAS | 56-75-7 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C11H12Cl2N2O5 |
| Isisindo samangqamuzana | 323.13 |
| I-Melting Point | 149.0 kuye ku-153.0℃ (lit.) |
| Kuyazwela | Ukukhanya Okuzwelayo |
| Ukuncibilika | Incibilika Kakhulu ku-Ethanol, Methanol, Acetone.I-Soluble ku-Ether, i-Chloroform.Ayincibiliki ku-Benzene.Ayincibiliki Emanzini |
| Isimo Sokuthumela | Kuthunyelwe Ngaphansi Kwezinga Lokushisa Le-Ambient |
| I-COA ne-MSDS | Iyatholakala |
| Umsuka | Shanghai, China |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Emhlophe Kuya Kumphuzi Okhanyayo |
| Ukuhlonza A | Ukumuncwa kwe-infrared |
| Ukuhlonza B | Isikhathi sokugcinwa kwenani eliphakeme le-chromatogram yokulungiselelwa kwe-Assay sihambisana naleso esiku-chromatogram yokulungiselelwa Okujwayelekile, njengoba kutholwe ku-Assay. |
| Ukuzungezisa Okukhethekile | +17.0°~+20.0° |
| I-Melting Point | 149.0~153.0℃ |
| I-Crystallinity | Ihlangabezana Nezimfuneko |
| pH | 4.5~7.5 |
| Ukungcola Okukodwa | ≤0.50% |
| Ukungcola Okuphelele | ≤1.00% |
| Izinsimbi Ezisindayo | ≤20ppm |
| I-Arsenic | ≤1ppm |
| Ukulahlekelwa Ekumisweni | ≤0.50% (105℃, amahora angu-3) |
| Izinsalela ekushiseni | ≤0.10% |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.0% (HPLC) |
| Izinga Lokuhlola | Izinga lebhizinisi;JP;USP |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama.
I-Chloramphenicol
C11H12Cl2N2O5 323.13 [56-75-7].
I-Chloramphenicol iqukethe amaphesenti angekho ngaphansi kuka-97.0 futhi angabi ngaphezu kwamaphesenti angu-103.0 we-C11H12Cl2N2O5.
Ukupakisha nokugcina-Londoloza ezitsheni eziqinile.
Ukulebula-Lapho ihloselwe ukusetshenziswa ekulungiseni amafomu omthamo omjovo noma amanye amagciwane, ilebula ithi ayinyumba noma kufanele iqhubeke nokucutshungulwa ngesikhathi sokulungiswa komjovo noma amanye amafomu omthamo oyinyumba.
Amazinga ereferensi we-USP <11>-
USP Chloramphenicol RS Chofoza ukuze Ubuke Isakhiwo
USP Endotoxin RS
Ukuhlonza-
A: I-Infrared Absorption <197K>.
B: Isikhathi sokugcinwa sesiqongo esikhulu ku-chromatogram yokulungiselelwa kwe-Assay sihambisana naleso esiku-chromatogram yokulungiselelwa Okujwayelekile, njengoba kutholwe ku-Assay.
Ibanga lokuncibilika <741>: phakathi kuka-149 no-153.
Ukuzungezisa okuqondile <781S>: phakathi kuka-+17.0 kanye no-+20.0.
Isixazululo sokuhlola: 50 mg, esomisiwe, i-mL ngayinye, kutshwala obungenawo amanzi.
I-Crystallinity <695>: ihlangabezana nezidingo.
Ama-endotoxin ebhaktheriya 85-Lapho i-Chloramphenicol ihloselwe ukusetshenziswa ekulungiseni amafomu omthamo omjovo, iqukethe iyunithi ye-Endotoxin engaphezu kuka-0.2 USP ngemg ngayinye ye-chloramphenicol.
I-Sterility 71- Lapho ilebula ithi i-Chloramphenicol ayinyumba, ihlangabezana nezimfuneko lapho ihlolwa njengoba kuqondiswe Ukuhlunga Kwe-Membrane ngaphansi Kokuhlolwa Kobunyumba Bomkhiqizo okufanele Uhlolwe, ngaphandle kokusebenzisa u-1 g wesampula esiqinile.
i-pH <791>: phakathi kuka-4.5 no-7.5, ekumisweni okumanzi okuqukethe u-25 mg nge-mL ngayinye.
I-Chromatographic purity-Chaza inani elinembile le-Chloramphenicol ku-methanol ukuze uthole isisombululo sokuhlola esiqukethe u-10 mg nge-mL ngayinye.Lungiselela isixazululo se-USP Chloramphenicol RS ku-methanol equkethe u-10 mg ngemL (Isixazululo Esijwayelekile A).Nciphisa izingxenye zekhambi Elijwayelekile A ngobuningi nge-methanol ukuze uthole isixazululo Esijwayelekile B esiqukethe u-100 µg ngemL ngayinye kanye nesixazululo Esijwayelekile C esiqukethe u-50 µg ngemL ngayinye.Faka izingxenye ezihlukene ezingu-20-µL zesixazululo sokuhlola nezisombululo Ezijwayelekile B no-C epuletini le-chromatographic elifanele elendlalelo encane (bona i-Chromatography 621), elimbozwe ngelendlalelo elingu-0.25-mm lengxube yejeli ye-chromatographic.Yakha i-chromatogram ohlelweni lokuncibilikisa oluhlanganisa ingxube ye-chloroform, i-methanol, ne-glacial acetic acid (79:14:7) kuze kube yilapho i-solvent front inyakaza cishe izingxenye ezintathu kwezine zobude bepuleti.Khipha ipuleti ekamelweni, liwomise emoyeni, bese lihlola ngaphansi kokukhanya kwe-UV yamaza amafushane amaza: noma iyiphi indawo ngaphandle kwendawo eyinhloko etholwe esixazululweni sokuhlola aweqeli ngosayizi noma ukuqina kwendawo eyinhloko etholwe kusixazululo Esijwayelekile B (1% ), kanye nesamba sokungcola okumelelwe yizo zonke izindawo ngaphandle kwendawo eyinhloko, ngokusekelwe ekuqhathanisweni kokuqina kwalezo zindawo nokuqina kwezindawo eziyinhloko ezitholwe ezixazululweni ezijwayelekile B no-C, aseqeli u-2% .
Isivivinyo-
Isigaba seselula-Lungiselela ingxube ehlungiwe efanelekile yamanzi, i-methanol, ne-glacial acetic acid (55:45:0.1).Yenza izinguquko uma kudingeka (bona Ukufaneleka Kwesistimu ngaphansi kwe-Chromatography 621).
Ukulungiselela okujwayelekile- Chaza isamba esikalwe ngokunembile se-USP Chloramphenicol RS kusigaba Seselula, futhi uhlambulule ngobuningi, nangesinyathelo esilandelanayo uma kudingeka, ngesigaba Seselula ukuze uthole isixazululo esinokugxila okwaziwayo okungaba ngu-80 µg ngemL ngayinye.Hlunga ingxenye yalesi sixazululo ngesihlungi esingu-0.5-µm noma se-porosity kakhudlwana, futhi usebenzise isihlungi esicacile njengokulungiselelwa Okujwayelekile.
Ukulungiselela i-assay- Dlulisa cishe u-200 mg we-Chloramphenicol, ukalwe ngokunembile, ku-100-mL ye-volumetric flask, engeza isigaba se-Mobile kuvolumu, bese uxuba.Dlulisa u-4.0 mL wesixazululo esiwumphumela ku-100-mL ye-volumetric flask, hlanza ngesigaba Seselula ukuya kuvolumu, bese uxuba.Hlunga ingxenye yalesi sixazululo ngesihlungi esingu-0.5-µm noma se-porosity kakhudlwana, futhi usebenzise isihlungi esicacile njengokulungiselelwa kwe-Assay.
Isistimu ye-Chromatographic (bona i-Chromatography <621>)-I-chromatograph ewuketshezi ifakwe umtshina ongu-280-nm kanye nekholomu engu-4.6-mm × 10-cm equkethe 5-µm ukupakisha L1.Izinga lokugeleza licishe libe ngu-1 mL ngomzuzu.I-Chromatograph ukulungiselelwa Okujwayelekile, futhi urekhode izimpendulo eziphakeme njengoba kuqondiswe ngaphansi Kwenqubo: ukusebenza kahle kwekholomu okunqunywe kusukela ekuphakameni kwe-analyte akukhona ngaphansi kwamapuleti etiyetha ayi-1800, isici somsila asingaphezu kuka-2.0, futhi ukuchezuka okujwayelekile okuhlobene kwemijovo eyimpinda akukhona. ngaphezu kuka-1.0%.
Inqubo--[nothi-Sebenzisa ukuphakama okuphezulu lapho kuboniswa khona izimpendulo eziphezulu.] Jova ngokuhlukana amavolumu alinganayo (cishe u-10 µL) wokulungiselela Okujwayelekile kanye nokulungiselelwa kwe-Assay ku-chromatograph, rekhoda ama-chromatogram, bese ukala izimpendulo zeziqongo ezinkulu.Bala inani, ngo-mg, le-C11H12Cl2N2O5 engxenyeni ye-Chloramphenicol ethathwe ifomula:
2.5C(rU / rS)
lapho u-C eyingqikithi, ku-µg nge-mL, ye-USP Chloramphenicol RS ekulungiseleleni Okujwayelekile, kanye ne-rU ne-rS izimpendulo eziphakeme ezitholwe ekulungiselelweni kokuhlola nasekulungiseleleni Okujwayelekile, ngokulandelanayo.
I-Chloramphenicol
I-C11H12Cl2N2O5: 323.13
2,2-Dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-nitrophenyl)propan-2-yl]acetamide [56-75-7]
I-Chloramphenicol iqukethe okungengaphansi kuka-980 mg (amandla) futhi ingabi ngaphezu kuka-1020 mg (amandla) nge-mg, ibalwa ngesisekelo esomisiwe.Amandla e-Chloramphenicol avezwa njengesisindo (amandla) we-chloramphenicol (C11H12Cl2N2O5).
Incazelo I-Chloramphenicol yenzeka imhlophe kuya kokuphuzi okumhlophe, amakristalu noma impushana ecwebezelayo.
Incibilika ngokukhululekile ku-methanol naku-ethanol (99.5), futhi inyibilika kancane emanzini.
Ukuhlonza (1) Nquma i-spectrum yokumuncwa kwesixazululo sesampula esitholwe ku-Assay njengoba kuqondiswe ngaphansi kwe-Ultraviolet-visible Spectrophotometry <2.24>, bese uqhathanisa i-spectrum ne-Reference Spectrum noma i-spectrum yesisombululo se-Chloramphenicol RS esilungiswe ngendlela efanayo ne isisombululo sesampula: zombili izibukeli zibonisa ukuqina okufanayo kokumuncwa ngamaza amaza afanayo.
(2) Nquma i-spectrum yokumuncwa kwe-infrared ye-Chloramphenicol njengoba kuqondiswe endleleni yediski ye-potassium bromide ngaphansi kwe-Infrared Spectrophotometry <2.25>, bese uqhathanisa i-spectrum ne-Reference Spectrum noma i-spectrum ye-Chloramphenicol RS: kokubili i-spectra ibonisa ukuqina okufanayo kokumuncwa okufanayo izinombolo zamagagasi.
Ukujikeleza kokubona <2.49> [a]20D: +18.5~+21.5℃ (1.25 g, ethanol (99.5), 25 mL, 100 mm).
Iphoyinti lokuncibilika <2.60> 150~155℃
Ukuhlanzeka (1) Izinsimbi ezinzima <1.07>-Qhubeka no-1.0 g we-Chloramphenicol ngokweNdlela 2, futhi wenze ukuhlolwa.Lungiselela ikhambi lokulawula ngo-2.5 mL we-Standard lead Solution (hhayi ngaphezu kuka-25 ppm).
(2) I-Arsenic <1.11>-Lungisa isixazululo sokuhlola nge-2.0 g ye-Chloramphenicol ngokweNdlela yesi-4, futhi wenze ukuhlolwa (hhayi ngaphezu kwe-1 ppm).
(3) Izinto ezihlobene-Chaza u-0.10 g we-Chloramphenicol ku-10 mL we-methanol, futhi usebenzise lesi sixazululo njengesampula yesixazululo.Ipayipi elingu-1 mL lesixazululo sesampula, engeza i-methanol ukuze wenze u-100 mL ngqo, bese usebenzisa lesi sixazululo njengesixazululo esijwayelekile (1).Ipayipi elingu-10 ml lekhambi elijwayelekile (1), engeza i-methanol ukuze wenze u-20 mL ngqo, bese usebenzisa lesi sixazululo njengesixazululo esijwayelekile (2).Yenza ukuhlolwa ngalezi zixazululo njengoba kuqondiswe ngaphansi kwe-Thin-layer Chromatography <2.03>.Faka i-20 ml ngayinye yesixazululo sesampula nezisombululo ezijwayelekile (1) kanye (2) epuletini lejeli yesilika elinenkomba ye-fluorescent yechromatography yongqimba oluncane, thuthukisa ipuleti ngengxube ye-chloroform, i-methanol ne-acetic acid (100) ( 79:14:7) ebangeni elicishe libe ngu-15 cm, bese womisa ipuleti ngomoya.Hlola ngaphansi kokukhanya kwe-ultraviolet (ubude begagasi obuyinhloko: 254 nm): amachashaza ngaphandle kwendawo eyinhloko kanye nebala elitholakala endaweni yokuqala etholwe esixazululweni sesampula akunamandla kakhulu kunendawo etholwe esixazululweni esivamile (1), kanye nesamba esiphelele. kulawa mabala avela kusixazululo sesampula awekho ngaphezu kuka-2.0%.
Ukulahlekelwa ekumisweni <2.41> Hhayi ngaphezulu kuka-0.5% (1 g, 105℃, amahora angu-3).
Insalela ekuthungeleni <2.44> Ayidluli ku-0.1%(1 g).
I-Assay Kala ngokunembile inani le-Chloramphenicol ne-Chloramphenicol RS, elilingana no-0.1 g (amandla), ncibilikisa ngayinye ngo-20 mL we-methanol, bese wengeza amanzi ukuze wenze u-100 mL ngqo.Pipe u-20 ml ngayinye yalezi zixazululo, bese wengeza amanzi ukwenza u-100 ml wangempela.Pipe 10 ml ngayinye yalezi zixazululo, engeza amanzi ukuze wenze u-100 mL ngqo, bese usebenzisa lezi zixazululo njengesixazululo esiyisampula kanye nesixazululo esijwayelekile.Nquma ama-absorbence, i-AT ne-AS, ku-278 nm yesixazululo sesampula kanye nesisombululo esijwayelekile njengoba kuqondiswe ngaphansi kwe-Ultraviolet-visible Spectrophotometry <2.24>.
Inani [mg (amandla)] le-chloramphenicol (C11H12Cl2N2O5)
＝ MS × AT/AS × 1000
MS: Inani [mg (amandla)] le-Chloramphenicol RS
kuthathwe
Iziqukathi nokugcina Iziqukathi-Tight iziqukathi.
Amakhodi Engozi R45 - Angabangela umdlavuza
I-R11 - Ivutha Kakhulu
R39/23/24/25 -
R23/24/25 - Ubuthi ngokuhogela, ukuthintana nesikhumba futhi uma ugwinywe.
Incazelo Yezokuphepha S53 - Gwema ukuchayeka - thola imiyalelo ekhethekile ngaphambi kokusetshenziswa.
S45 - Esimeni sengozi noma uma uzizwa ungaphilile, funa iseluleko sezokwelapha ngokushesha (bonisa ilebula noma nini lapho kunokwenzeka.)
S16 - Gcina kude nemithombo yokuthungela.
I-S36/37 - Gqoka izingubo zokuzivikela ezifanele namagilavu.
Ama-ID we-UN 2811
I-WGK Germany 3
I-RTECS AB6825000
I-FLUKA BRAND F AMAKHODI 3-10
TSCA Yebo
I-HS Code 2941400000
I-Hazard Class 3
Ubuthi LD50 oral in rat: 2500mg/kg
I-P501: Lahla okuqukethwe/isiqukathi endaweni egunyaziwe yokulahla udoti.
P260: Ungaluphefumuli uthuli/ umusi/ igesi/ inkungu/ umhwamuko/ fafaza.
I-P270: Ungadli, ungaphuzi noma ubheme lapho usebenzisa lo mkhiqizo.
I-P202: Ungayibambi kuze kube yilapho zonke izinyathelo zokuphepha sezifundiwe futhi zaqondwa.
I-P201: Thola iziyalezo ezikhethekile ngaphambi kokusetshenziswa.
I-P264: Geza isikhumba kahle ngemva kokuphatha.
I-P280: Gqoka amagilavu okuzivikela/ izingubo zokuzivikela/ ukuvikela iso/ ukuvikela ubuso.
I-P308 + P313: UMA iveziwe noma ukhathazekile: Thola iseluleko sezokwelapha/ukunakekelwa.
P405: Isitolo sivaliwe.
I-Shanghai Ruifu Chemical Co., Ltd. ingumnikezeli ohamba phambili we-Chloramphenicol (CAS: 56-75-7) enekhwalithi ephezulu.I-Chloramphenicol iyimithi elwa namagciwane ene-spectrum ebanzi, okuyindlela yokuqala yokwelapha i-typhoid ne-paratyphoid, okwesibili, isetshenziselwa ukwelapha izifo ezihlukahlukene ezithathelwanayo ezibangelwa amagciwane azwelayo.Ngenxa yokusabela okubi kakhulu manje asetshenziswa kancane kancane.I-spectrum ye-antibacterial, umsebenzi kanye nokusetshenziswa kuyafana ne-chloramphenicol yokwelapha i-Salmonella Typhi, i-Shigella, i-Escherichia coli, i-influenza, i-Brucella, izifo ze-pneumonia ezibangelwa i-cocci nezinye izidakamizwa ezilwa namagciwane.I-Chloramphenicol isetshenziselwa kakhulu ukwelapha izifo zomgudu womchamo, Inyumoniya, ukutheleleka kwesisu kanye ne-septicemia ebangelwa amagciwane azwelayo, kanye namaconsi angaphandle kwamehlo namathonsi endlebeni.
UN3249 Imithi, eqinile, enobuthi, nos, Ikilasi Lengozi: 6.1;Amalebula: 6.1-Izinto ezinobuthi.UN2811 Okuqinile okunobuthi, i-organic, nos, Ikilasi Lengozi: 6.1;Amalebula: 6.1- Izinto ezinobuthi, Igama Lobuchwepheshe Liyadingeka.
