I-Cisatracurium Besylate CAS 96946-42-8 Assay 95.0%~102.0% Ikhwalithi ephezulu ye-API Factory
Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Cisatracurium Besylate
I-CAS: 96946-42-8
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali | I-Cisatracurium Besylate |
Inombolo ye-CAS | 96946-42-8 |
Inombolo yeCAT | I-RF-API13 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C53H72N2O12.2C6H5O3S |
Isisindo samangqamuzana | 1243.49 |
I-Melting Point | 90.0~93.0℃ |
Isimo Sokuthumela | Ngaphansi Kwezinga Lokushisa Le-Ambient |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Emhlophe noma Ecishe Emhlophe, Ayinaphunga, I-Hygroscopic Kancane |
Ukuncibilika | Incibilika ngokukhululekile ku-dichloromethane, i-acetonitrile, inyibilika kancane emanzini |
Ukuzungezisa okuqondile | -35.0° ukuya -45.0° (C=10mg/ml, 0.1mg/ml benzene sulfonic acid) |
Ukuhlonza | Chaza nge-dilute hydrochoric acid, i-dropwise dilute bismuth potassium iodide TS, imvula ephuzi izokhiqizwa |
Ukuhlonza | 1. I-HPLC ;2. I-IR |
Isivivinyo | 95.0~102.0% (C65H82N2O18S2 ngokomisiwe) |
pH | 3.5 kuye ku-5.0 |
Ukucaca Nombala Wesixazululo | Kufanele Icace futhi Ingabi Nambala |
Ukulahlekelwa Ekumisweni | ≤2.0% |
Insalela ekushiseni | ≤0.20% |
Izinsimbi Ezisindayo | ≤20ppm |
I-Trans-Trans Isomer | ≤0.50% |
I-Cis-Trans Isomer | ≤0.50% |
Ama-mono-quaternaries | ≤1.50% |
Noma yikuphi Ukungcola Komuntu Ngamunye | ≤1.50% |
Ukungcola Okuphelele | ≤5.0% |
I-Optical Isomer SS-Isomer | ≤1.50% |
I-Optical Isomer RS- Isomer | ≤1.00% |
I-sulfate | ≤50ppm |
I-Ethyl | ≤0.50% |
I-acetone | ≤0.50% |
I-Methanol | ≤0.3% |
I-Dichloromethane | ≤0.06% |
I-acetonitrile | ≤0.041% |
I-methylbenzene | ≤0.089% |
I-Residual Solvents i-Acetonitrile | ≤410ppm |
Izinga Lokuhlola | I-Chinese Pharmacopoeia (CP) |
Ukusetshenziswa | I-Active Pharmaceutical Ingredient (API) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
![1](https://www.ruifuchemical.com/uploads/15.jpg)
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I-Cisatracurium Besylate (i-CAS 96946-42-8) iwuhlobo lwe-benzene sulfonate usawoti we-atracurium.Iwuhlobo lweziphumuli zokwenziwa zokwenziwa ezingezona-depolarizing ezinendima yazo efana ne-tubocurarine.Umthamo wokwelapha awuthinti inhliziyo, isibindi kanye nokusebenza kwezinso.Futhi ayinayo impahla yokuqongelela.Kungase futhi kubangele ukukhululwa kwe-histamine uma isetshenziswa ngemithamo emikhulu.Ukuze uthole ukuphumula kwemisipha noma ukulawula ukuphefumula okudingekayo ekuhlinzeni, uma kuqhathaniswa nezidakamizwa zamanje zomtholampilo ezinkulu eziphumuza imisipha, i-cisatracurium besylate ayifakwanga i-metabolized ngesibindi noma izinso, futhi inokusimama kwenhliziyo;umphumela wawo wokuphumula kwemisipha unamandla izikhathi ezingu-3 njenge-atracurium ngaphandle kwemiphumela emibi yenhliziyo.I-Cisatracurium besylate isetshenziswa ngokuyinhloko ku-anesthesia ejwayelekile, futhi ingasetshenziswa kabanzi ekungeneni, ekwelapheni ukungasebenzi kahle kwesibindi nezinso, okusetshenziselwa ukuhlinzwa kwenhliziyo nemithambo yegazi kanye neziguli ezikhulile nezezingane.Uma kuqhathaniswa ne-atracurium, lo mkhiqizo awunayo imiphumela emibi encike kumthamo wokukhishwa kwe-histamine;Nokho, okubi ukuthi iziguli ezinokukhubazeka kwesibindi nezinso kufanele zilawule ngokuqapha.Kusukela ngo-1996 ngokokuqala ngqa lapho lesi sidakamizwa singena emakethe e-UK, amazwe angaphandle asebenzise kancane kancane ukuze athathe indawo ye-vecuronium ne-atracurium njengendlela evamile yokuphumula kwemisipha yomtholampilo.
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