I-D-(+)-Cycloserine CAS 68-41-7 Assay ≥ 900μg/mg Factory High Quality
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-D-(+)-Cycloserine (CAS: 68-41-7) enekhwalithi ephezulu.I-Ruifu Chemical ingahlinzeka ngokulethwa komhlaba wonke, amanani ancintisanayo, amanani amancane nayinqwaba atholakalayo.Thenga i-D-(+)-Cycloserine,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | D-(+)-Cycloserine |
| Omqondofana | I-D-Cycloserine;(+)-Cycloserine;(R)-(+)-Cycloserine;(R)-(+)-4-Amino-3-Isoxazolidinone;I-Orientomycin;I-Oxamycin;I-α-Cycloserine |
| Isimo Sesitoko | Kukhona kusitoki |
| Inombolo ye-CAS | 68-41-7 |
| I-Molecular Formula | I-C3H6N2O2 |
| Isisindo samangqamuzana | 102.09 g/mol |
| I-Melting Point | 137℃ |
| Kuyazwela | Izwela Umoya, Izwela Ukushisa |
| Ukuncibilika | Incibilika Emanzini.Incibilika Kancane kuMethanol nePropylene Glycol.Ayincibiliki ku-Chloroform ne-Ether. |
| Isikhathi Sokugcina. | Indawo epholile neyomile (2~8℃) |
| I-COA ne-MSDS | Iyatholakala |
| Ibhrendi | I-Ruifu Chemical |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | I-Crystalline Powder Emhlophe noma Ephuzi Ngokuphaphathekile | Iyahambisana |
| Ukuzungezisa Okuthile [α]20/D | +108.0° ukuya +114.0° (C=5, 2N NaOH) | +111.9° |
| Ukuhlonza | Umbala Oluhlaza Wathuthukiswa Kancane Kancane | Umbala Oluhlaza |
| Imikhiqizo Ye-Condensation | ≤0.80% (ku-286nm) | 0.08% |
| Ukulahlekelwa Ekumisweni | <1.00% | 0.38% |
| Izinsalela ekushiseni | <0.50% | 0.10% |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
| Ukungcola Okuguquguqukayo | ||
| - Methanol | ≤500ppm | <500ppm |
| - I-acetone | ≤500ppm | <500ppm |
| I-Assay (Ama-Antibiotics-Microbial Assay) | ≥900μg/mg | 938μg/mg |
| pH | 5.5 kuya ku-6.5 | 5.98 |
| I-FTIR | Kuyavumelana | Kuyavumelana |
| I-IR Spectrum | Kuyavumelana | Kuyavumelana |
| I-NMR Spectrum | Kuyavumelana | Kuyavumelana |
| Isiphetho | Lo mkhiqizo ngokuhlola uvumelana ne-USP-35 ejwayelekile | |
I-Cycloserine [68-41-7].
I-Cycloserine inamandla angekho ngaphansi kuka-900µg we-C3H6N2O2 nge-mg.
Ukupakisha nokugcina-Londoloza ezitsheni eziqinile.
Amazinga ereferensi we-USP <11>-
USP Cycloserine RS
Ukuhlonza-Chaza cishe u-1 mg ku-10 mL we-0.1 N sodium hydroxide.Ku-1 mL wesixazululo esiwumphumela engeza u-3 mL we-1 N acetic acid no-1 mL wengxube, olungiselelwe ihora eli-1 ngaphambi kokusetshenziswa, izingxenye ezilinganayo zesisombululo se-sodium nitroprusside (1 ku-25) kanye ne-4 N sodium hydroxide: umbala oluhlaza kancane kancane. iyathuthuka.
Imikhiqizo ye-Condensation-Ukumuncwa kwayo (bona i-Spectrophotometry kanye ne-Light-Scattering <851>) ku-285 nm, enqunywe kusixazululo se-sodium hydroxide engu-0.1 N esiqukethe u-0.40 mg nge-mL ayidluli ku-0.80.
Ukuzungezisa okuqondile <781S>: phakathi kuka-108° no-114°.Isixazululo sokuhlola: 50 mg mL ngayinye, ku-2 N sodium hydroxide.
I-Crystallinity <695>: ihlangabezana nezidingo
pH <791>: phakathi kuka-5.5 no-6.5, kusixazululo (1 ku-10).
Ukulahlekelwa ekumisweni <731>-Yomisa cishe u-100 mg ebhodleleni le-capillar y-stoppered ku-vacuum engu-60℃ amahora angu-3: ilahlekelwa ngaphezu kuka-1.0% wesisindo sayo.
Insalela ekuthungeleni <281>: hhayi ngaphezu kuka-0.5%, insalela eshisiwe iswakanyiswe ngo-2 mL we-nitric acid namaconsi angu-5 e-sulfuric acid.
Isivivinyo-
I-pH 6.8 i-Phosphate buffer-Lungiselela njengoba kuqondiswe ku-Buffer Solutions ngaphansi kwezixazululo esigabeni esithi Ama-reagents, Izinkomba, kanye Nezixazululo.
Isigaba seselula-Diza u-0.5 g we-sodium 1-decanesulfonate ku-800 mL wamanzi, engeza u-50 mL we-acetonitrile no-5 mL we-glacial acetic acid, bese uxuba.Lungisa nge-1 N sodium hydroxide uye ku-pH engu-4.4.Hlunga, kanye ne-degas.Yenza izinguquko uma kudingeka y (bona Ukufaneleka Kwesistimu ngaphansi kwe-Chromatography <621>).
Ukulungiselela okujwayelekile-Ncibilikisa ngokwesilinganiso inani elinembile le-USP Cycloserine RS ku-pH 6.8 Phosphate buffer ukuze uthole isixazululo esinokugxila okwaziwayo okungaba ngu-0.4 mg nge-mL ngayinye.
Ukulungiselela i-assay-Dlulisa cishe u-20 mg we-Cycloserine, ukalwe ngokunembile, uye ku-50-mL ye-volumetric flask, ncibilika futhi uhlambulule nge-pH 6.8 Phosphate buffer kuvolumu, bese uxuba.
Isistimu ye-Chromatographic (bona i-Chromatography <621>)-I-chromatograph ewuketshezi ifakwe umtshina ongu-219-nm kanye nekholomu engu-4.6-mm × 25-cm equkethe 5- µm ukupakisha L1.Izinga lokugeleza licishe libe ngu-1 mL ngomzuzu.Izinga lokushisa lekholomu ligcinwa cishe ku-30 °.I-Chromatograph ukulungiselelwa Okujwayelekile, futhi urekhode izimpendulo eziphezulu njengoba kuqondiswe kuNqubo: isici somsila asingaphezu kuka-1.8;futhi ukuchezuka okujwayelekile okuhlobene kwemijovo eyimpinda akukho ngaphezu kuka-2.0%.
Inqubo-Ngokuhlukile jova amavolumu alinganayo (cishe u-10 µL) wokulungiswa Okujwayelekile kanye nokulungiswa kwe-Assay ku-chromatograph, rekhoda ama-chromatogram, futhi ulinganise izimpendulo eziphezulu ze-cycloserine.Bala inani, ku-µg, le-C3H6N2O2 ku-mg ngayinye ye-Cycloserine ethathwe ifomula:
50,000(C/W)(rU / rS)
lapho u-C eyingqikithi, ngo-mg nge-mL ngayinye, ye-USP Cycloserine RS ekulungiseleleni Okujwayelekile;W inani, ngo-mg, le-Cycloserine elithathwe ukuze kulungiswe ukulungiswa kwe-Assay;kanye ne-rU kanye ne-rS yizimpendulo eziphezulu ze-cycloserine ezitholwe ekulungiselelweni kwe-Assay nasekulungiseleleni Okujwayelekile, ngokulandelanayo.
Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile (2~8℃) kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Thumela emhlabeni wonke nge-FedEx / DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
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I-D-(+)-Cycloserine (CAS: 68-41-7) inemvelo eqinile ye-hygroscopic, iyancibilika emanzini, incibilika kancane kuma-alcohols aphansi, i-acetone ne-dioxane, futhi ayincibiliki kalula ku-chloroform ne-petroleum ether.Izinzile kusixazululo se-alkaline futhi ibola ngokushesha kuzixazululo ezine-asidi noma ezingathathi hlangothi.Njengemithi elwa namagciwane ene-spectrum ebanzi, i-cycloserine inhibitive kuma-bacterium amaningi e-Gram-positive kanye ne-Gram-negative, i-rickettsia namanye ama-protozoa, ngaphandle kwe-Mycobacterium tuberculosis. i-vinactane para-aminosalicylic acid, i-isoniazid ne-pyrazinamide.I-Cycloserine ihlangana kancane ne-isoniazid ekuvimbeleni i-Mycobacterium tuberculosis H37RV, kodwa ayihlanganisi futhi ayiphikisani ne-streptomycin.Umkhiqizo uyi-ejenti ye-bacteriostatic, ngakho-ke ngeke ube nomthelela wokubulala amagciwane ngisho nalapho unyusa umthamo noma welula isikhathi sokusebenza ngamagciwane.
I-Mechanism yesenzo se-antibacterial sika-D-cycloserine ukuvimbela i-biosynthesis ye-peptidoglycan yodonga lweseli.Njengoba iyi-analog yesakhiwo ye-D-alanine, i-D-cycloserine ingavimbela ngokuncintisana imisebenzi ye-alanine racemase kanye ne-D-alanyl-D-alanine synthetase, okungama-enzyme amabili abalulekile ekuhlanganiseni kwe-peptidoglycan.I-D-cycloserine ibonisa umsebenzi ovimbelayo obuthakathaka ngokumelene ne-Mycobacterium tuberculosis engu-1/10 kuphela kuya ku-1/20 we-streptomycin.Ubuhle bomkhiqizo ukuthi uyasebenza ezinhlotsheni zesifo sofuba esingazweli emuthini i-Mycobacterium futhi mancane amathuba okuthi ubangele ukumelana nemithi.Umkhiqizo ungasetshenziswa neminye imithi elwa nesifo sofuba ekwelapheni isifo sofuba esibangelwa isifo sofuba esingazweli emuthini i-Mycobacterium.
I-Cycloserine umuthi womugqa wesibili wokulwa nesifo sofuba.Ingavimbela ukukhula kwesifo sofuba i-Mycobacterium, kodwa umphumela ubuthakathaka uma kuqhathaniswa naleyo yemithi yomugqa wokuqala.Ukusebenza kwayo ekwelashweni kwesifo sofuba kuphansi kakhulu.Ukusebenzisa umuthi wodwa kungase kukhiqize ukumelana nomuthi, kodwa ukumelana kwenzeka kancane uma kuqhathaniswa nalokho kweminye imishanguzo elwa nesifo sofuba.Akukho ukumelana nesiphambano okutholakele phakathi kwe-cycloserine nezinye izidakamizwa zokulwa nesifo sofuba.Indlela yokusebenza kwayo kwe-antibacterial ukuvimbela ukwakheka kwe-peptidoglycan yodonga lweseli yebhaktheriya, okubangela ukungasebenzi kahle ekwakhiweni kodonga lwamaseli.Ingxenye eyinhloko yesakhiwo sodonga lwamaseli ebhaktheriya yi-peptidoglycan, eyakhiwe i-N-acetylglucosamine (GNAc) ne-N-acetylmuramic acid (MNAc).I-N-acetylmuramic acid ixhunywe ne-pentapeptide futhi ixhuma i-N-acetylglucosamine ngendlela ephindaphindiwe nehlukile.Ukwakheka kwe-cytoplasmic peptidoglycan precursor kungase kuvinjwe yi-cycloserine, njengoba le yakamuva ingavimbela i-racemase kanye ne-synthetase ye-D-Alanine, futhi ngaleyo ndlela ivimbele ukwakheka kwe-N-acetylmuramic acid.
I-D-Cycloserine ingatholakala ngokusebenzisa indlela yokuvubela noma ngokuhlanganisa okuqondile.Amagciwane asetshenziswa ekuvubeleni i-Actinomyces laven-dulae.I-fermentation medium iqukethe i-dextrin, i-dextrose, isitashi, i-soya powder, i-yeast powder, i-ammonium sulfate, i-ammonium nitrate, i-calcium carbonate, i-sodium chloride, i-magnesium sulfate namafutha e-soya.Enqubweni yokuhlanganiswa, i-D-Cycloserine itholakala ku-β-Aminooxy alanine ethyl ester hydrochloride ngokusabela nge-potassium hydroxide ekuphenduleni kwe-cyclization.
