I-D-Phenylalanine CAS 673-06-3 (HD-Phe-OH) Assay 98.0~102.0% Factory 50MT/Inyanga
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi oholayo nomphakeli we-D-Phenylalanine (HD-Phe-OH) (CAS: 673-06-3) enekhwalithi ephezulu, umthamo wokukhiqiza Amathani angu-50 Ngenyanga.I-D-Phenylalanine yaziwa amafekthri emithi asekhaya nezangaphandle kanye nezikhungo zocwaningo nentuthuko.I-Ruifu Chemical ihlinzeka ngochungechunge lokuphuma kokuphuma kwama-amino acid.Singahlinzeka nge-COA, ukulethwa komhlaba wonke, amanani amancane kanye nenqwaba etholakalayo.Uma unentshisekelo ku-D-Phenylalanine,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-D-Phenylalanine |
| Omqondofana | I-HD-Phe-OH;D-Phe;D-(+)-Phenylalanine;I-Dextro-Phenylalanine;(R)-Phenylalanine;(2R)-2-Amino-3-phenylpropanoic Acid;(R) -3-Phenyl-2-Aminopropanoic Acid;I-D-α-Amino-β-phenylpropionic Acid;I-D-alpha-Aminohydrocinnamic Acid;(R) -2-Amino-3-Phenylpropionic Acid;I-D-alpha-Amino-beta-Phenylpropionic Acid |
| Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani angama-50 ngenyanga |
| Inombolo ye-CAS | 673-06-3 |
| I-Molecular Formula | I-C9H11NO2 |
| Isisindo samangqamuzana | 165.19 |
| I-Melting Point | 273.0~276.0℃(lit.) |
| Ukuminyana | 1.201 |
| Ukuncibilika | I-Soluble in Water (30 mg/ml), i-Methanol (Kancane), 1 M HCl (50 mg/ml), i-Ethanol (<1 mg/ml at 25℃), kanye ne-DMSO (<1 mg/ml at 25℃) |
| Ukuncibilika Emanzini Ashisayo | Cishe Ukungafihli |
| Isikhathi Sokugcina. | Ivalwe Komile, Isitolo Emazingeni Okushisa Egumbi |
| I-COA ne-MSDS | Iyatholakala |
| Ukwahlukanisa | Ama-Amino Acid & Derivatives |
| Ibhrendi | I-Ruifu Chemical |
| Amakhodi Wengozi | Xi,C | I-RTECS | AY7533000 |
| Izitatimende Zobungozi | 34 - Ibangela ukusha | Inothi Lengozi | Iyacasula |
| Izitatimende Zokuphepha | 24/25-45-36/37/39-27-26 | I-TSCA | Yebo |
| I-WGK Germany | 3 | Ikhodi ye-HS | 2922491990 |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | Amakristalu Amhlophe noma I-Crystalline Powder | Kuyavumelana |
| Ukuhlonza | I-Infrared Absorption Spectrum | Kuyavumelana |
| Ukuzungezisa Okuthile [α]20/D | +33.5° ukuya +35.2°(C=2 ku-H2O) | + 33.6° |
| Isimo Sesixazululo (I-Transmittance) | ≥95.0% | Kuyavumelana |
| I-Chloride (Cl) | ≤0.020% | <0.020% |
| I-Sulfate (SO4) | ≤0.020% | <0.020% |
| I-Ammonium (NH4) | ≤0.020% | <0.020% |
| Insimbi (Fe) | ≤10ppm | <10ppm |
| Izinsimbi Ezisindayo (Pb) | ≤10ppm | <10ppm |
| I-Arsenic (As2O3) | ≤2.0ppm | <2.0ppm |
| Ukulahlekelwa Ekumisweni | ≤0.20% | 0.16% |
| Izinsalela ekushiseni (Sulfated) | ≤0.20% | 0.05% |
| I-D-Phenylalanine Purity | ≥99.0% (nge-HPLC) | 99.7% |
| I-D-Acetylphenylalanine | ≤0.10% | Ayitholakali |
| Izincibilikisi Ezisele | (ngu-GC) | |
| I-Ethanol | ≤5000ppm | Ayitholakali |
| I-acetone | ≤5000ppm | Ayitholakali |
| Isivivinyo | 98.0 kuya ku-102.0% (Kusisekelo Esomisiwe) | 99.7% |
| I-L-Phenylalanine | ≤0.10% (nge-HPLC) | 0.07% |
| I-Ninhydrin Positive Substances | ≤0.20% | <0.18% |
| Inani le-pH | 5.4 kuya ku-6.0 | 5.8 |
| Isiphetho | Lo Mkhiqizo Ngokuhlola Uvumelana Nezinga le-AJI97 | |
| Ukusetshenziswa Okuyinhloko | Abalamuli Bezemithi;AbaPhakathi bakwaChiral;njll. | |
1. Ukubukeka-- Ukuhlola okubonakalayo
2. Ukuzungezisa okuqondile-- Ukuzungezisa okukhethekile kukalwa ngokuhambisana ne-GB/T613-1988
Ukulungiselela isampula: Kala kahle isampula elingu-0.5000g bese ulihambisa ebhodleleni levolumu elihlanzekile nelomile elingu-50ml, engeza amanzi angama-20ml, umboze ibhodlela, ulinyakazise ukuze lincibilike, bese ulihlambulula esikalini ngamanzi.
Isivivinyo: Lungisa uziro we-gyroscope ngaphambi kokuhlolwa, bese ulayisha ithubhu lokuhlola ngesixazululo sesampula, urekhode i-engeli yokuzungezisa, futhi ubale ukuzungezisa okuthile kwesampula ngefomula elandelayo.
[а]D20 = (r×50) ÷(L×W)
Kuphi:
[а]D20: Ukujikeleza okuqondile kokubona ku-20℃ kwesixazululo sesampula
r: Ukuzungezisa okubonwa ku-20℃ ngesixazululo sesampula
50: Umthamo wesixazululo sesampula esilungisiwe (ml)
w: Isisindo sesampula (g)
L: Ubude beshubhu elijikelezayo lokubuka (dm)
3. Ukushisa izinsalela
Thatha cishe u-1g walo mkhiqizo uwushise ku-600 ℃, uwushise uze ube umlotha ngokuphelele ngokomthetho we-Appendix Ⅷ N weNgxenye II ye-CP2010 Edition, engeza u-0.5-1.0ml we-sulfuric acid egxilile bese uyishisa (700℃- 800℃) kuya esisindweni esingaguquki.
3.1 "Izinsalela ze-incandescent" kule Ndlela (I-Chinese Pharmacopoeia 2005 Edition, Ingxenye II Isithasiselo Ⅷ N) ibhekisela kuma-oxide ensimbi noma ama-sulfate asele ngemva kokuba izidakamizwa (ikakhulukazi izinhlanganisela eziphilayo) zishisiswe kuze kube umlotha ngokuphelele, bese i-sulfuric acid yengezwa 0.5 ~ 1.0ml futhi incandesced (700 ~ 800℃) kuya esisindweni njalo.
4 Chiral purity (HPLC)
Izinsimbi: Ukusebenza okuphezulu kwe-liquid chromatography, umtshina we-PDA.Ibhalansi yokuhlaziya ye-elekthronikhi, i-reagent;Izinga le-chromatography
Izimo ze-Chromatographic: Ikholomu: Ikholomu ye-Astec CHIROBIOTICTMT HPLC 250X4.6mm,5ul, ubude begagasi lokutholwa, izinga lokugeleza, usayizi wesampula :10 u L(inkomba) mncane kakhulu: amanzi, isikhathi sokuqoqwa kwedatha :20.00min.
Ukunqunywa kwesampula: Isampula yahlaziywa ngokuya ngenqubo yesampula elandelayo :inaliti engu-1 yesisombululo esingenalutho kanye nenaliti engu-1 yereferensi ye-DL-phenylalanine.
Isixazululo senaliti esiyisampula esingu-1,
Ukubalwa Kwemiphumela: Okuqukethwe kwe-HPLC kunqunywe ukuthi kungaphansi kuka-0.5% ngokuya ngokujwayelekile kwendawo ephakeme kanye nokubanjwa okungenalutho.
5. Eyomile futhi engenasisindo
5.1 Izinsimbi:
I-ovini yokomisa i-Thermostatic, ibhalansi engu-1/10,000.
5.2 Inqubo:
Ebhodleleni lesisindo esiyisicaba elinesisindo esingaguquki kanye nesembozo somlomo womhlabathi omiswe ngokweqile, kala igremu elingu-1 (elinembile ukuya ku-0.0001 igremu) lesampula.Isampula kufanele isatshalaliswe ngokulinganayo ngaphansi kwebhodlela lesisindo ngogqinsi olungekho ngaphezu kuka-10mm, ifakwe kuhhavini wokomisa kagesi we-thermostatic, yome ku-105-110 ℃ amahora angu-3, bese ingena ekamelweni lokumisa ukuze iphole. izinga lokushisa lekamelo lokukala.
Ukubala: Ukuncipha kwesisindo okomile %= (M1-M2) ÷M×100
Kuphi: M1: Inqwaba yesampula nebhodlela lokulinganisa ngaphambi kokoma, amagremu
I-M2: Inqwaba yesampula nebhodlela lokulinganisa ngemva kokumiswa, ngamagremu
M: Isisindo sesampula, amagremu
Isinyathelo sesi-6: Okuqukethwe
6.1 Izinsimbi
Ukusebenza okuphezulu kwe-chromatography ye-liquid, umtshina we-PDA.
Ibhalansi yokuhlaziya ye-elekthronikhi
6.2 Ama-reagents
I-Acetonitrile (ibanga le-chromatographic), i-TFA(ibanga le-chromatographic)
6.3 Izimo zeChromatographic
6.3.1 Ikholomu: YMC-ODS-AM, 5 μL, 150x4.6 mm
6.3.2 Ubude begagasi bokutholwa: INC220nm
Izinga lokugeleza: 1.0mL/min
Usayizi wesampula: 10μL(okwereferensi)
Okuncane: I-Acetonitrile
Isikhathi sokuqoqwa kwedatha: 20.00min
6.4 Ukulungiselela isigaba sikamakhalekhukhwini
Isigaba seselula A (0.1% samanzi e-trifluoroacetic acid): ukumuncwa okunembayo 2. Nciphisa i-Oml trifluoroacetic acid ngamanzi ukuya ku-2000m1, hlanganisa kahle, kanye ne-degas;
Isigaba seselula B(0.1% i-acetonitrile trifluoroacetic acid): ukumuncwa okunembile kwe-2.Oml trifluoroacetic acid yahlanjululwa yaba ngu-2000m1 nge-acetonitrile, exutshwe futhi yachithwa;
6.5 Uhlelo lwesigaba samaselula
Isikhathi (amaminithi) A% B%
0.00 90 10
12.00 10 90
15.00 10 90
15.01 90 10
20.00 90 10
6.6 Ukulungiswa kwesixazululo sesampula
Kala futhi uncibilikise isampula engu-0.1g nge-acetonitrile, nciphisa ibe ngu-100m1, xukuza kahle ukuze uyisebenzise, noma ukugxila okufanayo.Lungiselela amasampula amabili ngokuhambisana.
6.7 Ukunqunywa kwesampula
Hlaziya isampula ngokuya ngenqubo yamasampula elandelayo:
Umjovo ongaphezu ko-1 wesixazululo esingenalutho
Isampula yenaliti eyisampula yesixazululo 1#
1 isampula yenaliti yesixazululo 2#
6.8 Ukubalwa kwemiphumela
2.8.1 Indlela yokujwayela yendawo ephakemeyo yasetshenziswa ukubala ubumsulwa be-HPLC ngokudonsa indawo engenalutho.
2.8.2 Isilinganiso sokuchezuka kwesihlobo sokuhlanzeka kwezinalithi ezimbili akumele sibe ngaphezu kuka-1%
2.8.3 Uma imiphumela yayo yomibili imijovo ihlangabezana nemibandela yokwamukelwa, ukuhlanzeka okumaphakathi kuthathwa njengomphumela wokugcina.
Iphakheji: Ibhodlela eliFluorinated, 25kg/bag, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile, eyomile futhi engenamoya kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
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Ukusetshenziswa kwe-D-Phenylalanine (CAS: 673-06-3)
I-D-Phenylalanine iyi-D-enantiomer ye-phenylalanine.Kuyi-phenylalanine kanye ne-D-alpha-amino acid.I-D-Phenylalanine iyi-chiral ephakathi ebaluleke kakhulu ku-organic synthesis, esetshenziswa kabanzi ekuthuthukisweni kwezidakamizwa ezintsha, ukuhlanganiswa kwezinhlanganisela ze-polypeptide nezinye izimaphakathi zemithi.Futhi ngenxa ye-D-Phenylpropyl amino acid ngokwayo isakhiwo kanye nomsebenzi okhethekile, uye wadonsa ukunaka kwabantu abaningi.I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili kanye nomphakeli we-D-Phenylalanine e-China.
1. Ukusetshenziswa okuyinhloko kwe-D-Phenylalanine njengesithasiselo sezempilo kuwukukhululeka kokungakhululeki.Kungase futhi kusize ekusekeleni imisebenzi yemizwa nehlangene.I-D-Phenylalanine ingavimbela ukwehluleka komzimba womuntu, inesenzo se-antipyretic ne-analgesic.
2. I-D-Phenylalanine iyisithako semithi ikakhulukazi esetshenziselwa ukwelashwa nokuvimbela i-osteoporosis, i-cardiovascular, isifo sikashukela, i-arteriosclerosis nezinye izifo.
3. I-D-Phenylalanine Isetshenziswa njenge-pharmaceutical intermediate noma i-API ukuze kuhlanganiswe izidakamizwa ezifana ne-Nateglinide.Ukhiye omaphakathi wemithi ye-HIV protease depressant;impahla eluhlaza yemithi emisha yokulwa nomdlavuza kanye nemithi yokwelapha isifo sikashukela
4. I-D-Phenylalanine nayo ingasetshenziswa njengesithako sokudla, i-sweetener.
5. I-D-Phenylalanine iyi-inhibitor yama-enzyme eyenza i-enkephalins isebenze.Ama-Enkephalin ama-peptide afana ne-morphine ayenzeka ngokwemvelo asebenza ukunciphisa ubuhlungu.Ngokuvimbela ama-enzyme kusuka enkephalins ehlazisayo, i-D-Phenylalanine inganciphisa ubuhlungu obukhulu.
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