I-Dantrolene Sodium Salt Hydrate CAS 14663-23-1 API Factory High Quality
Nikeza Ngokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Dantrolene Sodium Salt Hydrate
I-CAS: 14663-23-1
I-Skeletal Muscle Relaxant.I-Calcium Channel Inhibitor
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso
| Igama Lekhemikhali | I-Dantrolene Sodium Salt Hydrate |
| Omqondofana | 1-[5-(4-Nitrophenyl)furfurylideneamino]hydantoin Sodium Salt Hydrate |
| Inombolo ye-CAS | 14663-23-1 |
| Inombolo yeCAT | I-RF-API78 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifika Emakhulwini Amakhilogremu |
| I-Molecular Formula | I-C14H11N4NaO5 |
| Isisindo samangqamuzana | 338.25 |
| Ukuncibilika | I-Soluble ku-DMSO |
| Isimo Sokuthumela | Kuthunyelwe Ngaphansi Kwezinga Lokushisa Le-Ambient |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Okuphuzi-Owolintshi ukuya ku-Orange Crystalline Powder.Abukho ubufakazi obubonakalayo bokungcoliswa yindaba yangaphandle |
| Ukuhlonza A | I-IR Absorption (197K) |
| Ukuhlonza B | Isikhathi sokugcina sesiqongo esikhulu ku-chromatogram yokulungiselelwa kokuhlolwa sihambisana naleso esiku-chromatogram yokulungiselelwa okujwayelekile, njengoba kutholwe ku-assay. |
| Ukuhlonza C | Ihlangabezana nezimfuneko zokuhlolwa kwelangabi le-Sodium (191) |
| Identification D | Ingxenye 1: Imvula enamandla, emhlophe, nekristalu iyakhiwa Ingxenye 2: Imvula ayishabalali Ingxenye 3: Imvula incibilika ngokuphelele Ingxenye 4: Akukho mvula okwakhiwayo |
| Okuqukethwe kwamanzi (nge-KF) | 14.5%~17.0% |
| Usayizi Wezinhlayiyana | 90% ngaphansi kuka-200um |
| Isivivinyo | 90.0%~96.0% we-C14H10N405 kusisekelo se-anhydrous |
| Izinto Ezihlobene | (HPLC, Area%) |
| Inhlanganisela Ehlobene A | ≤0.15% |
| Inhlanganisela Ehlobene B | ≤0.50% |
| Inhlanganisela Ehlobene C | ≤0.30% |
| Izincibilikisi Ezisele | |
| I-Ethanol | ≤2000ppm |
| I-Methanol | ≤2000ppm |
| I-acetone | ≤2000ppm |
| I-DMF | ≤620ppm |
| Izinsimbi Ezisindayo | ≤10ppm |
| I-Shelf Life | iminyaka engu-2 |
| Izinga Lokuhlola | I-United States Pharmacopoeia (USP) |
| Ukusetshenziswa | I-Skeletal Muscle Relaxant.I-Calcium Channel Inhibitor |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-Dantrolene Sodium Salt Hydrate (i-CAS 14663-23-1), i-molecule encane inhibitor ye-Ryonodine receptor antagonist kanye ne-Calcium channel inhibitor.I-Dantrolene Sodium Salt iyisiphuzo semisipha yamathambo, esivimbela ukukhishwa kwe-Ca 2+ engaphakathi kwe-sarcoplasmic reticulum.Ukuvinjwa kokukhululwa kwe-Ca2+ ku-reticulum ye-sarcoendoplasmic, ehlobene kakhulu nesasasa nokufinyela kwemisipha, kudala umphumela wokuphumuza imisipha ohambisana ne-Dantrolene.I-neurotoxicity eyethulwa umsebenzi oshiwo we-glutamate ihlotshaniswa nokukhuphuka ngokweqile kumazinga e-cytoplasmic Ca2+, futhi i-Dantrolene ikhonjiswa ngokufanele njenge-ejenti ye-neuroprotective ngokumelene ne-neurotrasmitter-induced excitotoxicity.I-Dantrolene, i-Sodium Salt iyi-inhibitor ye-RyR-1 ne-RyR-3.
