I-DAPT (GSI-IX) CAS 208255-80-5 γ-Secretase Inhibitor Assay >98.0% (HPLC) Factory
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-DAPT (GSI-IX) (CAS: 208255-80-5) enekhwalithi ephezulu, γ-Secretase Inhibitor.I-Ruifu Chemical ihlinzeka ngochungechunge lwama-amino acid nokuphuma kokunye.Singahlinzeka ngokudiliva emhlabeni wonke, amanani amancane futhi ngobuningi atholakalayo.Thenga i-DAPT,Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | I-DAPT |
| Omqondofana | I-GSI-IX;γ-Secretase Inhibitor IX;i-gamma-Secretase Inhibitor;I-LY-374973;(3,5-Difluorophenylacetyl)-Ala-Phg-OtBu;(3,5-Difluorophenylacetyl)-L-Alanyl-L-2-Phenylglycine tert-Butyl Ester;N-[N-(3,5-Difluorophenacetyl)-L-Alanyl]-S-Phenylglycine t-Butyl Ester;(2S)-N-[2-(3,5-Difluorophenyl)acetyl]-L-Alanyl-2-Phenyl-glycine 1,1-Dimethylethyl Ester |
| Isimo Sesitoko | Kukhona kusitoki |
| Inombolo ye-CAS | 208255-80-5 |
| I-Molecular Formula | I-C23H26F2N2O4 |
| Isisindo samangqamuzana | 432.47 |
| Ukuminyana | 1.213 g/cm3 |
| I-Melting Point | 142.0~146.0℃ |
| Kuyazwela | Ukushisa Kuyazwela |
| Ukuncibilika | I-Soluble ku-DMSO |
| Isikhathi Sokugcina. | Gcina ku-2-8℃ |
| I-COA ne-MSDS | Iyatholakala |
| Ibhrendi | I-Ruifu Chemical |
| Izitatimende Zokuphepha | 24/25 - Gwema ukuthintana nesikhumba namehlo. | ||
| I-WGK Germany | 3 | Ikhodi ye-HS | 2922491990 |
| Izinto | Amazinga Wokuhlola | Imiphumela |
| Ukubukeka | I-Crystalline Powder Emhlophe noma Engamhlophe | Kuyavumelana |
| Ukulahlekelwa Ekumisweni | <0.40% | 0.21% |
| Izinsalela ekushiseni | <0.40% | 0.20% |
| Izinsimbi Ezisindayo (njenge-Pb) | ≤20ppm | <20ppm |
| Indlela Yokuhlola / Yokuhlaziya | >98.0% (HPLC) | 98.62% |
| Ikhabhoni ngokuhlaziywa kwe-Elemental | 62.1~64.1% | Kuyavumelana |
| Nitrogen by Elemental Analysis | 6.20~6.70% | Kuyavumelana |
| I-Infrared Spectrum | Ivumelana Nesakhiwo | Kuyavumelana |
| I-NMR Spectrum | Ivumelana Nesakhiwo | Kuyavumelana |
| Isiphetho | Lo Mkhiqizo Ngokuhlola Uvumelana Nezinga Lebhizinisi | |
| I-Shelf Life | Izinyanga ezingama-24 Kusuka Kudethi Yokukhiqiza Uma Igcinwe Ngokufanelekile | |
Iphakheji: Ibhodlela eliFluorinated, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile, eyomile (esitolo ku-2-8℃) kanye nendlu yokugcina impahla engenisa umoya kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.
Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.
Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.
IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.
Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.
Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.
I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.
Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.
Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.
Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.
Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.
Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.
I-DAPT (GSI-IX) (CAS: 208255-80-5), inhibitor enamandla futhi ethize ye-γ-secretase.I-DAPT iyisivimbeli se-γ-secretase (IC50 kuma-neurons ayinhloko womuntu = 115 nM yengqikithi ye-Aβ noma i-200 nM ye-Aβ42 ngokuqondile).Ukuphathwa komlomo kwe-DAPT kuboniswe ukunciphisa amazinga e-Aβ ekukhishweni kobuchopho, uketshezi lwe-cerebrospinal kanye ne-plasma evela kumagundane namagundane.I-DAPT ivimba ukusayinda kwe-Notch okukhuthaza ukuhlukaniswa kwe-neuronal yamaseli andulelayo.Ithuthukisa amaseli e-iPS ngaphandle kwe-oncogenes KLF4 kanye ne-CMYC5.Iseli liyangeneka.I-DAPT isetshenziswa ocwaningweni lokubunjwa kwe-β-amyloid.I-DAPT ikhonjiswe ukuthi ivimbela ukusayinda kwe-Notch ocwaningweni lwezifo ezizimele kanye ne-lymphoproliferative, njenge-ALPS ne-lupus erythematosus, kanye nasekukhuleni kwamangqamuzana omdlavuza, i-angiogenesis, kanye nokuhlukaniswa kwamaseli esiqu enziwe umuntu.Ivimbela ukusayina kwe-Notch ku-vitro.Ivimbela ukukhiqizwa okuphelele kwe-Aβ ne-Aβ42 kumasiko abantu ayisisekelo (amanani e-IC50 angu-115 no-200 nM, ngokulandelanayo) ngaphandle komthelela kumazinga e-APPα ne-APPβ.Isithiyo sobuchopho-gazi siyangeneka.Ingxenye ye-3D Growth matrix kanye nengxenye yemidiya yokuhlukanisa i-cerebral organoid.
