I-Daptomycin CAS 103060-53-3 Purity ≥95.0% API Factory High Purity

Incazelo emfushane:

Igama Lekhemikhali: Daptomycin

I-CAS: 103060-53-3

Ukubukeka: Impushana Ephuzi noma Ephuzi Ephaphathekile

Ubumsulwa: ≥95.0% (Ibalwa ngokomisiwe)

I-Daptomycin ekwelapheni ezinye izifo zesikhumba eziyinkimbinkimbi kanye nezicubu ezithambile ezibangelwa amagciwane egram-positive.

Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Inquiry: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
Igama Lekhemikhali: Daptomycin
I-CAS: 103060-53-3
Ikhwalithi ephezulu ye-API, Ukukhiqiza Kwezentengiso

Chemical Properties:

Igama Lekhemikhali	I-Daptomycin
Omqondofana	I-LY146032
Inombolo ye-CAS	103060-53-3
Inombolo yeCAT	I-RF-API10
Isimo Sesitoko	Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani
I-Molecular Formula	I-C72H101N17O26
Isisindo samangqamuzana	1620.69
I-Melting Point	202.0~204.0℃
Ukuncibilika	I-Solube ku-Methanol
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Into	Imininingwane
Ukubukeka	Impushana Ephuzi noma Ephaphathekile
Ukuhlonza HPLC	Isikhathi sokugcinwa kwesilinganiso esiphezulu sesixazululo sesampula kufanele sihambisane naleso sezinga lesithenjwa.
Ukuhlonza IR	I-spectrum ye-IR yesampula yokuhlola kufanele ihambisane nohlobo lwe-IR yereferensi evamile.
Ukubukeka Kwesixazululo	Ukucaca Isixazululo kufanele sicace noma singashiwo kakhudlwana kunaleso sokumiswa kwereferensi II.
I-Specific Optical Rotation	+17.0° ukuze +25.0°
pH	4.0 kuye ku-5.0
Izinsalela ekushiseni	≤1.0%
I-Anhydro-Daptomycin	≤2.5%
β-Isomer	≤0.50%
Ukungcola kwe-Hydrolysis	≤0.50%
Ukungcola 1	≤0.75%
Ukungcola 2	≤0.75%
Ukungcola 3	≤0.75%
Noma Ikuphi Okunye Ukungcola	≤0.15%
Ukungcola Okuphelele	≤5.0%
Izinsimbi Ezisindayo	≤30ppm
Amanzi	≤5.0%
Ubumsulwa	≥95.0% (Ibalwa ngokomisiwe)
Ama-bacterium Endotoxins	<0.3EU/mg
I-Residual Solvents n-Butanol	≤5000ppm
I-ResidualSolvents Isopropanol	≤5000ppm
I-Residual Solvents Ethanol	≤5000ppm
Umkhawulo weMicrobial TAMC	≤100cfu/g
I-Microbial Limit TYMC	≤10cfu/g
E.Coil	Akutholwanga
Izinga Lokuhlola	I-Enterprise Standard
Izimo Zokugcina	Londoloza ezitsheni eziqinile, futhi ugcine ku -25~-10 ℃.
Ukusetshenziswa	I-Active Pharmaceutical Ingredient (API)

Iphakheji nesitoreji:

Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.

Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.

Izinzuzo:

I-FAQ:

Isicelo:

I-Daptomycin (CAS: 103060-53-3) iwuhlobo lwe-cyclic lipopeptide antibiotics enesakhiwo senoveli.Ikhishwa ku-Streptomyces fermentation broth.Yatholwa yi-Eli Lilly Company ngeminyaka yawo-1980, futhi yathuthukiswa ngempumelelo ngo-1997 ngabakwaCubist Pharmaceuticals.Ayigcini nje ngokuba nesakhiwo samakhemikhali esinoveli kuphela kodwa futhi inendlela yokwenza ehlukile kunoma iyiphi i-antibiotic egunyazwe ngaphambili: ivimbela iseli ngokuphazamisa ukuthuthwa kwama-amino acid ngolwelwesi lwamangqamuzana, ngaleyo ndlela ivimbe i-peptidoglycan biosynthesis yodonga lweseli futhi iguqule ubunjalo bomzimba. ulwelwesi lwamaseli.Ingacekela phansi ulwelwesi lwamaseli ebhaktheriya ezicini eziningi, futhi ibulale ngokushesha amagciwane egram-positive.Ngaphezu kwendima yokuba nomthelela kumagciwane amaningi anegram-positive abalulekile ngokomtholampilo, okubaluleke kakhulu, i-Daptomycin inamandla amakhulu ekwelapheni izinhlobo ezihlukene eziye zabonisa izimpawu zokungazweli i-methicillin, i-vancomycin ne-linezolid.Lesi sakhiwo sibaluleke kakhulu ezigulini ezihlushwa izifo ezinzima.NgoSepthemba 2003, i-US Food and Drug Administration igunyaze okokuqala ukuthi i-Daptomycin (CAS: 103060-53-3) ifakwe ekwelapheni izifo ezinzima zesikhumba.Ngo-March 2006, yagunyazwa ukwelapha izifo ezithathelwanayo.NgoJanuwari 2006, igunyazwe yiKhomishini YaseYurophu yokwelapha izifo ezithile zesikhumba nezicubu ezithambile ezibangelwa amagciwane egram-positive.Ngo-September 6, 2007, i-Cubist Pharmaceuticals yamemezela ukuthi i-European Union igunyaze isidakamizwa sayo se-antibacterial, i-Cubicin yokwelashwa kwe-endocarditis yenhliziyo efanele ebangelwa izifo ze-Staphylococcus aureus kanye nezifo eziyinkimbinkimbi zesikhumba nezicubu ezithambile ezihlobene ne-Staphylococcus aureus.